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[Malignant syphilis in patient with human immunodeficiency virus (HIV): case report and literature review].
An Med Interna. 2003 Jul; 20(7):373-6.AM

Abstract

Malignant syphilis is an infrequent manifestation of syphilis in HIV infected patients. Only 21 cases have been published in medical literature. Most frequent in men, 62%, the mean age of presentation is 34 years. The most frequent symptoms are: 100% ulcerative cutaneous lesions, 47% fever and 33% ocular affectation. About 80% of the patients have a CD4 count >200. Lues serological test was 100% positive and 81% responded to penicillin. We report a 18 year old woman diagnosed of HIV infection, admitted to our service because of fever, painful oral sores, over-elevated eritematous lesions and cratered ulcers all over the body, with the initial suspicion of chickenpox. Lues serology turned out to be positive, as well as the Warthin Starry stain. After penicillin treatment was initiated, skin lesions improved, although residual lesions currently persist. Malignant syphilis should be considered in infected HIV patients with fever and ulcerated skin injuries as a possible diagnosis. Eventhough serological tests allow diagnosis confirmation, Warthin Starry stain can be useful when serology is negative. The first choice of treatment is penicillin and in case of penicillin allergy, a third generation cefalosporine should be used.

Authors+Show Affiliations

Unidad de Enfermedades Infecciosas de Medicina Interna. Hospital Infanta Elena, Huelva, Spain. manujromeroj@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article
Review

Language

spa

PubMed ID

12951968

Citation

Romero-Jiménez, M J., et al. "[Malignant Syphilis in Patient With Human Immunodeficiency Virus (HIV): Case Report and Literature Review]." Anales De Medicina Interna (Madrid, Spain : 1984), vol. 20, no. 7, 2003, pp. 373-6.
Romero-Jiménez MJ, Suárez Lozano I, Fajardo Picó JM, et al. [Malignant syphilis in patient with human immunodeficiency virus (HIV): case report and literature review]. An Med Interna. 2003;20(7):373-6.
Romero-Jiménez, M. J., Suárez Lozano, I., Fajardo Picó, J. M., & Barón Franco, B. (2003). [Malignant syphilis in patient with human immunodeficiency virus (HIV): case report and literature review]. Anales De Medicina Interna (Madrid, Spain : 1984), 20(7), 373-6.
Romero-Jiménez MJ, et al. [Malignant Syphilis in Patient With Human Immunodeficiency Virus (HIV): Case Report and Literature Review]. An Med Interna. 2003;20(7):373-6. PubMed PMID: 12951968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Malignant syphilis in patient with human immunodeficiency virus (HIV): case report and literature review]. AU - Romero-Jiménez,M J, AU - Suárez Lozano,I, AU - Fajardo Picó,J M, AU - Barón Franco,B, PY - 2003/9/4/pubmed PY - 2003/11/11/medline PY - 2003/9/4/entrez SP - 373 EP - 6 JF - Anales de medicina interna (Madrid, Spain : 1984) JO - An Med Interna VL - 20 IS - 7 N2 - Malignant syphilis is an infrequent manifestation of syphilis in HIV infected patients. Only 21 cases have been published in medical literature. Most frequent in men, 62%, the mean age of presentation is 34 years. The most frequent symptoms are: 100% ulcerative cutaneous lesions, 47% fever and 33% ocular affectation. About 80% of the patients have a CD4 count >200. Lues serological test was 100% positive and 81% responded to penicillin. We report a 18 year old woman diagnosed of HIV infection, admitted to our service because of fever, painful oral sores, over-elevated eritematous lesions and cratered ulcers all over the body, with the initial suspicion of chickenpox. Lues serology turned out to be positive, as well as the Warthin Starry stain. After penicillin treatment was initiated, skin lesions improved, although residual lesions currently persist. Malignant syphilis should be considered in infected HIV patients with fever and ulcerated skin injuries as a possible diagnosis. Eventhough serological tests allow diagnosis confirmation, Warthin Starry stain can be useful when serology is negative. The first choice of treatment is penicillin and in case of penicillin allergy, a third generation cefalosporine should be used. SN - 0212-7199 UR - https://www.unboundmedicine.com/medline/citation/12951968/[Malignant_syphilis_in_patient_with_human_immunodeficiency_virus__HIV_:_case_report_and_literature_review]_ L2 - http://www.diseaseinfosearch.org/result/9735 DB - PRIME DP - Unbound Medicine ER -