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BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumonia.
Eur Respir J. 2003 Aug; 22(2):239-44.ER

Abstract

Idiopathic pulmonary fibrosis (IPF), which has the histological pattern of usual interstitial pneumonia (UIP), is a progressive interstitial lung disease with a poor prognosis. Idiopathic interstitial pneumonias with a histological pattern of nonspecific interstitial pneumonia (NSIP) have a better prognosis than UIP, and may present with a clinical picture identical to IPF. The authors hypothesised that bronchoalveolar lavage (BAL) findings may distinguish between UIP and NSIP, and have prognostic value within disease subgroups. BAL findings were studied retrospectively in 54 patients with histologically proven (surgical biopsy) idiopathic UIP (n=35) or fibrotic NSIP (n=19), all presenting clinically as IPF. These findings were also compared with the BAL profile of patients with other categories of idiopathic interstitial pneumonias. BAL total and differential cell counts did not differ between the two groups. Survival was better in NSIP. In neither group were BAL findings predictive of survival or changes in lung function at 1 yr, even after adjustment for disease severity, smoking and treatment. BAL differential counts in fibrotic NSIP differed from respiratory bronchiolitis-associated interstitial lung disease, but not from desquamative interstitial pneumonia or cellular NSIP. The authors conclude that bronchoalveolar lavage findings do not discriminate between usual interstitial pneumonia and nonspecific interstitial pneumonia in patients presenting with clinical features of idiopathic pulmonary fibrosis, and have no prognostic value, once the distinction between the two has been made histologically.

Authors+Show Affiliations

Interstitial Lung Disease Unit, Dept of Occupational and Environmental Medicine, Royal Brompton Hospital, National Heart and Lung Institute, Imperial College of Science Technology and Medicine, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

12952254

Citation

Veeraraghavan, S, et al. "BAL Findings in Idiopathic Nonspecific Interstitial Pneumonia and Usual Interstitial Pneumonia." The European Respiratory Journal, vol. 22, no. 2, 2003, pp. 239-44.
Veeraraghavan S, Latsi PI, Wells AU, et al. BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumonia. Eur Respir J. 2003;22(2):239-44.
Veeraraghavan, S., Latsi, P. I., Wells, A. U., Pantelidis, P., Nicholson, A. G., Colby, T. V., Haslam, P. L., Renzoni, E. A., & du Bois, R. M. (2003). BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumonia. The European Respiratory Journal, 22(2), 239-44.
Veeraraghavan S, et al. BAL Findings in Idiopathic Nonspecific Interstitial Pneumonia and Usual Interstitial Pneumonia. Eur Respir J. 2003;22(2):239-44. PubMed PMID: 12952254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - BAL findings in idiopathic nonspecific interstitial pneumonia and usual interstitial pneumonia. AU - Veeraraghavan,S, AU - Latsi,P I, AU - Wells,A U, AU - Pantelidis,P, AU - Nicholson,A G, AU - Colby,T V, AU - Haslam,P L, AU - Renzoni,E A, AU - du Bois,R M, PY - 2003/9/4/pubmed PY - 2004/1/24/medline PY - 2003/9/4/entrez SP - 239 EP - 44 JF - The European respiratory journal JO - Eur Respir J VL - 22 IS - 2 N2 - Idiopathic pulmonary fibrosis (IPF), which has the histological pattern of usual interstitial pneumonia (UIP), is a progressive interstitial lung disease with a poor prognosis. Idiopathic interstitial pneumonias with a histological pattern of nonspecific interstitial pneumonia (NSIP) have a better prognosis than UIP, and may present with a clinical picture identical to IPF. The authors hypothesised that bronchoalveolar lavage (BAL) findings may distinguish between UIP and NSIP, and have prognostic value within disease subgroups. BAL findings were studied retrospectively in 54 patients with histologically proven (surgical biopsy) idiopathic UIP (n=35) or fibrotic NSIP (n=19), all presenting clinically as IPF. These findings were also compared with the BAL profile of patients with other categories of idiopathic interstitial pneumonias. BAL total and differential cell counts did not differ between the two groups. Survival was better in NSIP. In neither group were BAL findings predictive of survival or changes in lung function at 1 yr, even after adjustment for disease severity, smoking and treatment. BAL differential counts in fibrotic NSIP differed from respiratory bronchiolitis-associated interstitial lung disease, but not from desquamative interstitial pneumonia or cellular NSIP. The authors conclude that bronchoalveolar lavage findings do not discriminate between usual interstitial pneumonia and nonspecific interstitial pneumonia in patients presenting with clinical features of idiopathic pulmonary fibrosis, and have no prognostic value, once the distinction between the two has been made histologically. SN - 0903-1936 UR - https://www.unboundmedicine.com/medline/citation/12952254/BAL_findings_in_idiopathic_nonspecific_interstitial_pneumonia_and_usual_interstitial_pneumonia_ L2 - http://erj.ersjournals.com/cgi/pmidlookup?view=long&pmid=12952254 DB - PRIME DP - Unbound Medicine ER -