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[Manometric effects of pinaverium bromide in irritable bowel syndrome].
Acta Gastroenterol Latinoam. 1992; 22(1):37-43.AG

Abstract

The effects of pinaverium bromide on colonic motility were investigated in a controlled, controlled, cross-over study in 32 patients with irritable bowel syndrome. Constipation was clearly predominant in one group of 16 patients, and diarrhea in the other group of 16. Manometric measurements were taken of the colonic motor response generated by distention of a balloon inserted to the rectosigmoid junction. Measurements were taken before and one hour after ingestion of two tablets containing placebo or two tablets each containing 50 mg of pinaverium bromide. Following intake of placebo the motility index increased from the basal value in patients with constipation, and resistance to distention decreased in the diarrhea group. These changes were attributable to repetition of the mechanical stimulus within a relatively brief time lapse, or more probably to the ingestion of liquid which accompanied intake of tablets. Compared with placebo, pinaverium bromide induced inhibition of both effects. From the therapeutic point of view, the decrease in motility index seen in patients with irritable bowel syndrome and constipation is particularly interesting.

Authors+Show Affiliations

Servicio de Gastroenterología, Hospital Italiano, Buenos Aires.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

spa

PubMed ID

1295286

Citation

Soifer, L, et al. "[Manometric Effects of Pinaverium Bromide in Irritable Bowel Syndrome]." Acta Gastroenterologica Latinoamericana, vol. 22, no. 1, 1992, pp. 37-43.
Soifer L, Varela E, Olmos J. [Manometric effects of pinaverium bromide in irritable bowel syndrome]. Acta Gastroenterol Latinoam. 1992;22(1):37-43.
Soifer, L., Varela, E., & Olmos, J. (1992). [Manometric effects of pinaverium bromide in irritable bowel syndrome]. Acta Gastroenterologica Latinoamericana, 22(1), 37-43.
Soifer L, Varela E, Olmos J. [Manometric Effects of Pinaverium Bromide in Irritable Bowel Syndrome]. Acta Gastroenterol Latinoam. 1992;22(1):37-43. PubMed PMID: 1295286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Manometric effects of pinaverium bromide in irritable bowel syndrome]. AU - Soifer,L, AU - Varela,E, AU - Olmos,J, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 37 EP - 43 JF - Acta gastroenterologica Latinoamericana JO - Acta Gastroenterol Latinoam VL - 22 IS - 1 N2 - The effects of pinaverium bromide on colonic motility were investigated in a controlled, controlled, cross-over study in 32 patients with irritable bowel syndrome. Constipation was clearly predominant in one group of 16 patients, and diarrhea in the other group of 16. Manometric measurements were taken of the colonic motor response generated by distention of a balloon inserted to the rectosigmoid junction. Measurements were taken before and one hour after ingestion of two tablets containing placebo or two tablets each containing 50 mg of pinaverium bromide. Following intake of placebo the motility index increased from the basal value in patients with constipation, and resistance to distention decreased in the diarrhea group. These changes were attributable to repetition of the mechanical stimulus within a relatively brief time lapse, or more probably to the ingestion of liquid which accompanied intake of tablets. Compared with placebo, pinaverium bromide induced inhibition of both effects. From the therapeutic point of view, the decrease in motility index seen in patients with irritable bowel syndrome and constipation is particularly interesting. SN - 0300-9033 UR - https://www.unboundmedicine.com/medline/citation/1295286/[Manometric_effects_of_pinaverium_bromide_in_irritable_bowel_syndrome]_ L2 - http://www.diseaseinfosearch.org/result/3876 DB - PRIME DP - Unbound Medicine ER -