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Clinical aspects and outcomes of volunteer blood donors testing positive for hepatitis-C virus infection in Taiwan: a prospective study.
Liver Int 2003; 23(3):148-55LI

Abstract

BACKGROUND/AIM

The natural history of hepatitis-C virus (HCV) infection has been explored in volunteer blood donors, but not yet in hepatitis-B endemic areas. Whether previous or concurrent hepatitis-B virus (HBV) infection influences the natural history of HCV infection remains unknown. Thus, we followed the anti-HCV-positive blood donors who had past or concurrent HBV infection in Taiwan.

METHODS

From 1992 to 1993, 1588 anti-HCV reactive volunteer blood donors were referred to us from the Taipei Blood Center and 879 (55%) repeatedly reactive for anti-HCV were enrolled. Two hundred and forty-three donors (HCV RNA seropositive rate 49% by polymerase chain reaction (PCR)) received regular follow-ups (mean period: 4.9 years) with their liver disease status determined mainly by clinical and biochemical parameters, serum alpha-fetoprotein level and imaging studies. Hepatitis-C virus genotype and occult HBV infection were determined by PCR-based assays.

RESULTS

Of the initial 879 subjects, 250 (28%) had chronic hepatitis, nine (1%) had liver cirrhosis (LC) and two (0.2%) had hepatocellular carcinoma (HCC) already. In the 243 regularly followed donors, 30% had repeatedly normal serum alanine aminotransferase (ALT) and 70% had more than once elevated ALT. Cirrhosis developed in four (1.6%; follow-up period range: 2-6 years) and HCC in two (0.8%; follow-up period: 3 and 4 years, respectively). Distribution of HCV genotype and hepatitis-B surface antigen (HBsAg) did not differ between those with and those without elevation of ALT. Of the 15 donors with LC and/or HCC, only 1(7%) was positive for both HBsAg and HBV DNA and the other 14 were negative for both HBsAg and serum HBV DNA.

CONCLUSIONS

Incidentally detected hepatitis-C was progressive in a small proportion of anti-HCV-positive volunteer blood donors in Taiwan. Occult HBV infection played a minimal role in the development of LC in this donor population.

Authors+Show Affiliations

Department of Internal Medicine, National Taiwan University College of Medicine, National Taiwan University Hospital, 1 Chang-Te Street, Taipei 100, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12955877

Citation

Liu, Chun-Jen, et al. "Clinical Aspects and Outcomes of Volunteer Blood Donors Testing Positive for hepatitis-C Virus Infection in Taiwan: a Prospective Study." Liver International : Official Journal of the International Association for the Study of the Liver, vol. 23, no. 3, 2003, pp. 148-55.
Liu CJ, Chen PJ, Shau WY, et al. Clinical aspects and outcomes of volunteer blood donors testing positive for hepatitis-C virus infection in Taiwan: a prospective study. Liver Int. 2003;23(3):148-55.
Liu, C. J., Chen, P. J., Shau, W. Y., Kao, J. H., Lai, M. Y., & Chen, D. S. (2003). Clinical aspects and outcomes of volunteer blood donors testing positive for hepatitis-C virus infection in Taiwan: a prospective study. Liver International : Official Journal of the International Association for the Study of the Liver, 23(3), pp. 148-55.
Liu CJ, et al. Clinical Aspects and Outcomes of Volunteer Blood Donors Testing Positive for hepatitis-C Virus Infection in Taiwan: a Prospective Study. Liver Int. 2003;23(3):148-55. PubMed PMID: 12955877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical aspects and outcomes of volunteer blood donors testing positive for hepatitis-C virus infection in Taiwan: a prospective study. AU - Liu,Chun-Jen, AU - Chen,Pei-Jer, AU - Shau,Wen-Yi, AU - Kao,Jia-Horng, AU - Lai,Ming-Yang, AU - Chen,Ding-Shinn, PY - 2003/9/6/pubmed PY - 2003/12/3/medline PY - 2003/9/6/entrez SP - 148 EP - 55 JF - Liver international : official journal of the International Association for the Study of the Liver JO - Liver Int. VL - 23 IS - 3 N2 - BACKGROUND/AIM: The natural history of hepatitis-C virus (HCV) infection has been explored in volunteer blood donors, but not yet in hepatitis-B endemic areas. Whether previous or concurrent hepatitis-B virus (HBV) infection influences the natural history of HCV infection remains unknown. Thus, we followed the anti-HCV-positive blood donors who had past or concurrent HBV infection in Taiwan. METHODS: From 1992 to 1993, 1588 anti-HCV reactive volunteer blood donors were referred to us from the Taipei Blood Center and 879 (55%) repeatedly reactive for anti-HCV were enrolled. Two hundred and forty-three donors (HCV RNA seropositive rate 49% by polymerase chain reaction (PCR)) received regular follow-ups (mean period: 4.9 years) with their liver disease status determined mainly by clinical and biochemical parameters, serum alpha-fetoprotein level and imaging studies. Hepatitis-C virus genotype and occult HBV infection were determined by PCR-based assays. RESULTS: Of the initial 879 subjects, 250 (28%) had chronic hepatitis, nine (1%) had liver cirrhosis (LC) and two (0.2%) had hepatocellular carcinoma (HCC) already. In the 243 regularly followed donors, 30% had repeatedly normal serum alanine aminotransferase (ALT) and 70% had more than once elevated ALT. Cirrhosis developed in four (1.6%; follow-up period range: 2-6 years) and HCC in two (0.8%; follow-up period: 3 and 4 years, respectively). Distribution of HCV genotype and hepatitis-B surface antigen (HBsAg) did not differ between those with and those without elevation of ALT. Of the 15 donors with LC and/or HCC, only 1(7%) was positive for both HBsAg and HBV DNA and the other 14 were negative for both HBsAg and serum HBV DNA. CONCLUSIONS: Incidentally detected hepatitis-C was progressive in a small proportion of anti-HCV-positive volunteer blood donors in Taiwan. Occult HBV infection played a minimal role in the development of LC in this donor population. SN - 1478-3223 UR - https://www.unboundmedicine.com/medline/citation/12955877/Clinical_aspects_and_outcomes_of_volunteer_blood_donors_testing_positive_for_hepatitis_C_virus_infection_in_Taiwan:_a_prospective_study_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1478-3223&date=2003&volume=23&issue=3&spage=148 DB - PRIME DP - Unbound Medicine ER -