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Associations between serum transferrin receptor concentrations and erythropoietic activities according to body iron status.
Ann Clin Lab Sci. 2003 Summer; 33(3):279-84.AC

Abstract

This study investigated the associations between serum transferrin receptor (sTfR) concentrations and erythropoietic activities during 3 stages of iron deficiency in humans. Serum iron markers, fluorescent intensity of reticulocytes, and sTfR concentrations were measured in 227 prepubescent children, age 9 to 12 yr. Reticulocyte subpopulations were analyzed by flow cytometry and sTfR concentrations were measured by enzyme immunoassay. Mean values of middle-fluorescence reticulocytes (MFR), reticulocyte maturity index (RMI), and sTfR concentrations were significantly higher in iron-deficiency anemia subjects than in healthy controls. Reticulocyte subpopulations increased gradually, as body iron status diminished; the mean values of MFR and RMI in subjects with serum ferritin concentrations < 4.0 microg/L were 3-fold higher than those in healthy controls (p < 0.01). Correlation coefficients of MFR and RMI vs log ferritin values (r = 0.43 and r = 0.42) were higher than those of MFR and RMI vs sTfR concentrations (r = 0.24 and r = 0.27) in iron-deficiency anemia subjects. In summary, iron deficiency leads to increased production of immature reticulocytes. Erythropoietic activity is more closely associated with log ferritin values than with sTfR concentrations in iron-deficiency anemia.

Authors+Show Affiliations

Department of Laboratory Medicine, College of Medicine, Inha University, Inchon, South Korea. jwchoi@inha.ac.krNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12956442

Citation

Choi, Jong Weon, and Soo Hwan Pai. "Associations Between Serum Transferrin Receptor Concentrations and Erythropoietic Activities According to Body Iron Status." Annals of Clinical and Laboratory Science, vol. 33, no. 3, 2003, pp. 279-84.
Choi JW, Pai SH. Associations between serum transferrin receptor concentrations and erythropoietic activities according to body iron status. Ann Clin Lab Sci. 2003;33(3):279-84.
Choi, J. W., & Pai, S. H. (2003). Associations between serum transferrin receptor concentrations and erythropoietic activities according to body iron status. Annals of Clinical and Laboratory Science, 33(3), 279-84.
Choi JW, Pai SH. Associations Between Serum Transferrin Receptor Concentrations and Erythropoietic Activities According to Body Iron Status. Ann Clin Lab Sci. 2003;33(3):279-84. PubMed PMID: 12956442.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between serum transferrin receptor concentrations and erythropoietic activities according to body iron status. AU - Choi,Jong Weon, AU - Pai,Soo Hwan, PY - 2003/9/6/pubmed PY - 2004/4/14/medline PY - 2003/9/6/entrez SP - 279 EP - 84 JF - Annals of clinical and laboratory science JO - Ann Clin Lab Sci VL - 33 IS - 3 N2 - This study investigated the associations between serum transferrin receptor (sTfR) concentrations and erythropoietic activities during 3 stages of iron deficiency in humans. Serum iron markers, fluorescent intensity of reticulocytes, and sTfR concentrations were measured in 227 prepubescent children, age 9 to 12 yr. Reticulocyte subpopulations were analyzed by flow cytometry and sTfR concentrations were measured by enzyme immunoassay. Mean values of middle-fluorescence reticulocytes (MFR), reticulocyte maturity index (RMI), and sTfR concentrations were significantly higher in iron-deficiency anemia subjects than in healthy controls. Reticulocyte subpopulations increased gradually, as body iron status diminished; the mean values of MFR and RMI in subjects with serum ferritin concentrations < 4.0 microg/L were 3-fold higher than those in healthy controls (p < 0.01). Correlation coefficients of MFR and RMI vs log ferritin values (r = 0.43 and r = 0.42) were higher than those of MFR and RMI vs sTfR concentrations (r = 0.24 and r = 0.27) in iron-deficiency anemia subjects. In summary, iron deficiency leads to increased production of immature reticulocytes. Erythropoietic activity is more closely associated with log ferritin values than with sTfR concentrations in iron-deficiency anemia. SN - 0091-7370 UR - https://www.unboundmedicine.com/medline/citation/12956442/Associations_between_serum_transferrin_receptor_concentrations_and_erythropoietic_activities_according_to_body_iron_status_ L2 - http://www.annclinlabsci.org/cgi/pmidlookup?view=long&amp;pmid=12956442 DB - PRIME DP - Unbound Medicine ER -