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Effects of absorption rate on the pre-systemic chiral inversion of ibuprofen in rabbits.
J Pharm Pharmacol. 2003 Aug; 55(8):1091-7.JP

Abstract

The chiral inversion kinetics of ibuprofen was evaluated after intraduodenal administration of racemic ibuprofen in conventional powder form and sustained-released granules compared with intravenous administration in rabbits. The AUC ratios of the S-(+) and R-(-) enantiomers remained almost constant values with time up to 2 h after administration of sustained-release formulation, while those after administration of the powder increased with time. R-(-) enantiomer to S-(+) enantiomer inversion ratios after intraduodenal administration of the powder form and the sustained-release form, and after intravenous injection were calculated to be 1.63, 1.94 and 1.19, respectively, indicating that pharmacological effects may depend on the absorption rate in rabbits.

Authors+Show Affiliations

Department of Pharmacology and Therapeutics, Hokkaido College of Pharmacy, 7-1 Katsuraoka, Otaru 047-0264, Hokkaido, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12956898

Citation

Doki, Kosuke, et al. "Effects of Absorption Rate On the Pre-systemic Chiral Inversion of Ibuprofen in Rabbits." The Journal of Pharmacy and Pharmacology, vol. 55, no. 8, 2003, pp. 1091-7.
Doki K, Hayakawa T, Lin W, et al. Effects of absorption rate on the pre-systemic chiral inversion of ibuprofen in rabbits. J Pharm Pharmacol. 2003;55(8):1091-7.
Doki, K., Hayakawa, T., Lin, W., Yanaguimoto, H., Ding, G., & Inotsume, N. (2003). Effects of absorption rate on the pre-systemic chiral inversion of ibuprofen in rabbits. The Journal of Pharmacy and Pharmacology, 55(8), 1091-7.
Doki K, et al. Effects of Absorption Rate On the Pre-systemic Chiral Inversion of Ibuprofen in Rabbits. J Pharm Pharmacol. 2003;55(8):1091-7. PubMed PMID: 12956898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of absorption rate on the pre-systemic chiral inversion of ibuprofen in rabbits. AU - Doki,Kosuke, AU - Hayakawa,Toru, AU - Lin,Wenhui, AU - Yanaguimoto,Hitomi, AU - Ding,Guohua, AU - Inotsume,Nobuo, PY - 2003/9/6/pubmed PY - 2004/1/6/medline PY - 2003/9/6/entrez SP - 1091 EP - 7 JF - The Journal of pharmacy and pharmacology JO - J Pharm Pharmacol VL - 55 IS - 8 N2 - The chiral inversion kinetics of ibuprofen was evaluated after intraduodenal administration of racemic ibuprofen in conventional powder form and sustained-released granules compared with intravenous administration in rabbits. The AUC ratios of the S-(+) and R-(-) enantiomers remained almost constant values with time up to 2 h after administration of sustained-release formulation, while those after administration of the powder increased with time. R-(-) enantiomer to S-(+) enantiomer inversion ratios after intraduodenal administration of the powder form and the sustained-release form, and after intravenous injection were calculated to be 1.63, 1.94 and 1.19, respectively, indicating that pharmacological effects may depend on the absorption rate in rabbits. SN - 0022-3573 UR - https://www.unboundmedicine.com/medline/citation/12956898/Effects_of_absorption_rate_on_the_pre_systemic_chiral_inversion_of_ibuprofen_in_rabbits_ L2 - https://academic.oup.com/jpp/article-lookup/doi/10.1211/0022357021404 DB - PRIME DP - Unbound Medicine ER -