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The cannabinoid receptor antagonist SR-141716 does not readily antagonize open-field effects induced by the cannabinoid receptor agonist (R)-methanandamide in rats.
Pharmacol Biochem Behav. 2003 Jul; 75(4):809-21.PB

Abstract

This study examined the effects of the cannabinoid CB(1) receptor agonist (R)-methanandamide and the CB(1) receptor antagonist SR-141716 on open-field behaviors in rats. Animals were examined after administration of (R)-methanandamide (dose range 10 to 30 mg/kg) plus vehicle, and the two drugs in combination; the dose range of SR-141716 was 0.3 to 5.6 mg/kg. Injections were given intraperitoneally 20 min prior to initial testing. Additional exposures to the open-field arena occurred for the groups treated with 30 mg/kg (R)-methanandamide at 60 and 120 min post administration. There was a dose-related suppression of ambulation (horizontal activity) and rearing (vertical activity) after (R)-methanandamide administration. Coadministration of SR-141716 did not counteract the suppression induced by 10 and 18 mg/kg (R)-methanandamide but rather tended to augment it, especially with regard to ambulation using SR-141716 doses of 1 mg/kg and up. The latency to leave the starting area in the center of the field was significantly elevated by 30 mg/kg (R)-methanandamide. This effect was completely blocked by SR-141716. With increasing doses of SR-141716, there was an increase in grooming and scratching. Generally, the strongest effects occurred 20 min post administration with the exception of grooming, which reached maximum at 60 min post. Differences in the number of circlings, vocalizations, urination, and defecation generally did not differ clearly among treatments. These results coupled with previous open-field data examining combinations of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and SR-141716 [Pharmacol. Biochem. Behav. 73 (2002) 911] underscore pharmacological differences between (R)-methanandamide and Delta(9)-THC revealed by their interactions with SR-141716.

Authors+Show Affiliations

Department of Psychology, Temple University, Philadelphia, PA 19122, USA. tjarbe@astro.temple.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12957223

Citation

Järbe, Torbjörn U C., et al. "The Cannabinoid Receptor Antagonist SR-141716 Does Not Readily Antagonize Open-field Effects Induced By the Cannabinoid Receptor Agonist (R)-methanandamide in Rats." Pharmacology, Biochemistry, and Behavior, vol. 75, no. 4, 2003, pp. 809-21.
Järbe TU, DiPatrizio NV, Li C, et al. The cannabinoid receptor antagonist SR-141716 does not readily antagonize open-field effects induced by the cannabinoid receptor agonist (R)-methanandamide in rats. Pharmacol Biochem Behav. 2003;75(4):809-21.
Järbe, T. U., DiPatrizio, N. V., Li, C., & Makriyannis, A. (2003). The cannabinoid receptor antagonist SR-141716 does not readily antagonize open-field effects induced by the cannabinoid receptor agonist (R)-methanandamide in rats. Pharmacology, Biochemistry, and Behavior, 75(4), 809-21.
Järbe TU, et al. The Cannabinoid Receptor Antagonist SR-141716 Does Not Readily Antagonize Open-field Effects Induced By the Cannabinoid Receptor Agonist (R)-methanandamide in Rats. Pharmacol Biochem Behav. 2003;75(4):809-21. PubMed PMID: 12957223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cannabinoid receptor antagonist SR-141716 does not readily antagonize open-field effects induced by the cannabinoid receptor agonist (R)-methanandamide in rats. AU - Järbe,Torbjörn U C, AU - DiPatrizio,Nicholas V, AU - Li,Chen, AU - Makriyannis,Alexandros, PY - 2003/9/6/pubmed PY - 2004/4/14/medline PY - 2003/9/6/entrez SP - 809 EP - 21 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 75 IS - 4 N2 - This study examined the effects of the cannabinoid CB(1) receptor agonist (R)-methanandamide and the CB(1) receptor antagonist SR-141716 on open-field behaviors in rats. Animals were examined after administration of (R)-methanandamide (dose range 10 to 30 mg/kg) plus vehicle, and the two drugs in combination; the dose range of SR-141716 was 0.3 to 5.6 mg/kg. Injections were given intraperitoneally 20 min prior to initial testing. Additional exposures to the open-field arena occurred for the groups treated with 30 mg/kg (R)-methanandamide at 60 and 120 min post administration. There was a dose-related suppression of ambulation (horizontal activity) and rearing (vertical activity) after (R)-methanandamide administration. Coadministration of SR-141716 did not counteract the suppression induced by 10 and 18 mg/kg (R)-methanandamide but rather tended to augment it, especially with regard to ambulation using SR-141716 doses of 1 mg/kg and up. The latency to leave the starting area in the center of the field was significantly elevated by 30 mg/kg (R)-methanandamide. This effect was completely blocked by SR-141716. With increasing doses of SR-141716, there was an increase in grooming and scratching. Generally, the strongest effects occurred 20 min post administration with the exception of grooming, which reached maximum at 60 min post. Differences in the number of circlings, vocalizations, urination, and defecation generally did not differ clearly among treatments. These results coupled with previous open-field data examining combinations of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and SR-141716 [Pharmacol. Biochem. Behav. 73 (2002) 911] underscore pharmacological differences between (R)-methanandamide and Delta(9)-THC revealed by their interactions with SR-141716. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/12957223/The_cannabinoid_receptor_antagonist_SR_141716_does_not_readily_antagonize_open_field_effects_induced_by_the_cannabinoid_receptor_agonist__R__methanandamide_in_rats_ DB - PRIME DP - Unbound Medicine ER -