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Iron intake and regulation: implications for iron deficiency and iron overload.
Alcohol 2003; 30(2):99-102A

Abstract

Although iron deficiency anemia is the most common nutritional deficiency worldwide and in the United States, the health effects of iron overload merit increased attention. In the United States, public health interventions such as fortification and enrichment of foods with iron were undertaken to reduce the prevalence of iron deficiency anemia and improve health. These measures, along with iron supplementation, remain controversial, because additional exposure to dietary iron places some segments of the population at increased risk of iron excess. The health consequences of unmistakable iron excess are exemplified by hemochromatosis, an iron storage disease associated with liver damage further exacerbated by alcohol consumption. Progressive liver damage associated with this condition is generally attributed to increased oxidative stress. In otherwise healthy individuals, more modest levels of iron storage may occur if iron is provided by supplements or otherwise added to the food supply. Increased iron intake and storage have been linked to a variety of chronic diseases. The associations are not firmly established but are of considerable public health importance.

Authors+Show Affiliations

Office of Dietary Supplements, National Institutes of Health, 6100 Executive Boulevard, Room 3B01, MSC 7517, Bethesda, MD 20892-7517, USA. Swansonc@OD.NIH.GOV

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12957292

Citation

Swanson, Christine A.. "Iron Intake and Regulation: Implications for Iron Deficiency and Iron Overload." Alcohol (Fayetteville, N.Y.), vol. 30, no. 2, 2003, pp. 99-102.
Swanson CA. Iron intake and regulation: implications for iron deficiency and iron overload. Alcohol. 2003;30(2):99-102.
Swanson, C. A. (2003). Iron intake and regulation: implications for iron deficiency and iron overload. Alcohol (Fayetteville, N.Y.), 30(2), pp. 99-102.
Swanson CA. Iron Intake and Regulation: Implications for Iron Deficiency and Iron Overload. Alcohol. 2003;30(2):99-102. PubMed PMID: 12957292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron intake and regulation: implications for iron deficiency and iron overload. A1 - Swanson,Christine A, PY - 2003/9/6/pubmed PY - 2004/4/30/medline PY - 2003/9/6/entrez SP - 99 EP - 102 JF - Alcohol (Fayetteville, N.Y.) JO - Alcohol VL - 30 IS - 2 N2 - Although iron deficiency anemia is the most common nutritional deficiency worldwide and in the United States, the health effects of iron overload merit increased attention. In the United States, public health interventions such as fortification and enrichment of foods with iron were undertaken to reduce the prevalence of iron deficiency anemia and improve health. These measures, along with iron supplementation, remain controversial, because additional exposure to dietary iron places some segments of the population at increased risk of iron excess. The health consequences of unmistakable iron excess are exemplified by hemochromatosis, an iron storage disease associated with liver damage further exacerbated by alcohol consumption. Progressive liver damage associated with this condition is generally attributed to increased oxidative stress. In otherwise healthy individuals, more modest levels of iron storage may occur if iron is provided by supplements or otherwise added to the food supply. Increased iron intake and storage have been linked to a variety of chronic diseases. The associations are not firmly established but are of considerable public health importance. SN - 0741-8329 UR - https://www.unboundmedicine.com/medline/citation/12957292/Iron_intake_and_regulation:_implications_for_iron_deficiency_and_iron_overload_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0741832903001034 DB - PRIME DP - Unbound Medicine ER -