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Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog.
J Appl Physiol (1985). 2003 Dec; 95(6):2408-15.JA

Abstract

Capsiate is a nonpungent capsaicin analog, a recently identified principle of the nonpungent red pepper cultivar CH-19 Sweet. In the present study, we report that 2-wk treatment of capsiate increased metabolic rate and promoted fat oxidation at rest, suggesting that capsiate may prevent obesity. To explain these effects, at least in part, we examined uncoupling proteins (UCPs) and thyroid hormones. UCPs and thyroid hormones play important roles in energy expenditure, the maintenance of body weight, and thermoregulation. Two-week treatment of capsiate increased the levels of UCP1 protein and mRNA in brown adipose tissue and UCP2 mRNA in white adipose tissue. This dose of capsiate did not change serum triiodothyronine or thyroxine levels. A single dose of capsiate temporarily raised both UCP1 mRNA in brown adipose tissue and UCP3 mRNA in skeletal muscle. These results suggest that UCP1 and UCP2 may contribute to the promotion of energy metabolism by capsiate, but that thyroid hormones do not.

Authors+Show Affiliations

Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto Univ., Kyoto 606-8502, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12959953

Citation

Masuda, Yoriko, et al. "Upregulation of Uncoupling Proteins By Oral Administration of Capsiate, a Nonpungent Capsaicin Analog." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 95, no. 6, 2003, pp. 2408-15.
Masuda Y, Haramizu S, Oki K, et al. Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog. J Appl Physiol (1985). 2003;95(6):2408-15.
Masuda, Y., Haramizu, S., Oki, K., Ohnuki, K., Watanabe, T., Yazawa, S., Kawada, T., Hashizume, S., & Fushiki, T. (2003). Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog. Journal of Applied Physiology (Bethesda, Md. : 1985), 95(6), 2408-15.
Masuda Y, et al. Upregulation of Uncoupling Proteins By Oral Administration of Capsiate, a Nonpungent Capsaicin Analog. J Appl Physiol (1985). 2003;95(6):2408-15. PubMed PMID: 12959953.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog. AU - Masuda,Yoriko, AU - Haramizu,Satoshi, AU - Oki,Kasumi, AU - Ohnuki,Koichiro, AU - Watanabe,Tatsuo, AU - Yazawa,Susumu, AU - Kawada,Teruo, AU - Hashizume,Shu-ichi, AU - Fushiki,Tohru, Y1 - 2003/09/05/ PY - 2003/9/10/pubmed PY - 2004/7/9/medline PY - 2003/9/10/entrez SP - 2408 EP - 15 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J Appl Physiol (1985) VL - 95 IS - 6 N2 - Capsiate is a nonpungent capsaicin analog, a recently identified principle of the nonpungent red pepper cultivar CH-19 Sweet. In the present study, we report that 2-wk treatment of capsiate increased metabolic rate and promoted fat oxidation at rest, suggesting that capsiate may prevent obesity. To explain these effects, at least in part, we examined uncoupling proteins (UCPs) and thyroid hormones. UCPs and thyroid hormones play important roles in energy expenditure, the maintenance of body weight, and thermoregulation. Two-week treatment of capsiate increased the levels of UCP1 protein and mRNA in brown adipose tissue and UCP2 mRNA in white adipose tissue. This dose of capsiate did not change serum triiodothyronine or thyroxine levels. A single dose of capsiate temporarily raised both UCP1 mRNA in brown adipose tissue and UCP3 mRNA in skeletal muscle. These results suggest that UCP1 and UCP2 may contribute to the promotion of energy metabolism by capsiate, but that thyroid hormones do not. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/12959953/Upregulation_of_uncoupling_proteins_by_oral_administration_of_capsiate_a_nonpungent_capsaicin_analog_ L2 - https://journals.physiology.org/doi/10.1152/japplphysiol.00828.2002?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -