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Analysis of risk factors for hepatocellular carcinoma in patients with HBs antigen- and anti-HCV antibody-negative alcoholic cirrhosis: clinical significance of prior hepatitis B virus infection.
Alcohol Clin Exp Res 2003; 27(8 Suppl):47S-51SAC

Abstract

BACKGROUND

The hepatitis B virus (HBV) or hepatitis C virus (HCV) markers frequently are detected in alcoholic patients with hepatocellular carcinoma (HCC). However, risk factors for the development of HCC in patients with HBs antigen (Ag)- and anti-HCV antibody (anti-HCV)-negative alcoholic cirrhosis have not been clearly documented. The present study was conducted to elucidate the occurrence rates of HCC in HBs Ag- and anti-HCV-negative male alcoholic cirrhosis and to assess the risk factors for hepatocellular carcinogenesis.

METHOD

We prospectively studied 91 consecutive patients with HBs Ag- and anti-HCV-negative alcoholic cirrhosis for 0.5 to 12.5 years (median 5.9 years). Potential risk factors assessed for liver carcinogenesis included the following six variables: age, total alcohol intake, association of continuing alcohol intake after diagnosis, indocyanine green retention rate at 15 min, anti-HB core antibodies (anti-HBc), and association of diabetes mellitus.

RESULTS

Cumulative occurrence rates of HCC were 6.4%, 18.9%, and 28.7% at the end of the 5th, 7th and 10th years, respectively. When classified by anti-HBc, the occurrence rates of HCC in 31 patients with anti-HBc and 60 patients without anti-HBc were 15.6% and 2.9% at the 5th year, 28.4% and 13.5% at the 7th year, and 40.4% and 22.1% at the 10th year, respectively. The occurrence rates of HCC were also significantly related to the cumulative alcohol intake. Cox proportional hazard model identified that cumulative alcohol intake (p = 0.0047) and positive anti-HBc antibodies (p = 0.0598) were independently associated with the occurrence rates of HCC.

CONCLUSION

These epidemiologic results suggest that heavy cumulative alcohol intake and prior exposure to HBV infection are risk factors for the development of HCC in patients with HBs Ag- and anti-HCV-negative alcoholic cirrhosis.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, Koyabe, Yokosukashi, Kanagawaken, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12960507

Citation

Uetake, Shinichiro, et al. "Analysis of Risk Factors for Hepatocellular Carcinoma in Patients With HBs Antigen- and anti-HCV Antibody-negative Alcoholic Cirrhosis: Clinical Significance of Prior Hepatitis B Virus Infection." Alcoholism, Clinical and Experimental Research, vol. 27, no. 8 Suppl, 2003, 47S-51S.
Uetake S, Yamauchi M, Itoh S, et al. Analysis of risk factors for hepatocellular carcinoma in patients with HBs antigen- and anti-HCV antibody-negative alcoholic cirrhosis: clinical significance of prior hepatitis B virus infection. Alcohol Clin Exp Res. 2003;27(8 Suppl):47S-51S.
Uetake, S., Yamauchi, M., Itoh, S., Kawashima, O., Takeda, K., & Ohata, M. (2003). Analysis of risk factors for hepatocellular carcinoma in patients with HBs antigen- and anti-HCV antibody-negative alcoholic cirrhosis: clinical significance of prior hepatitis B virus infection. Alcoholism, Clinical and Experimental Research, 27(8 Suppl), 47S-51S.
Uetake S, et al. Analysis of Risk Factors for Hepatocellular Carcinoma in Patients With HBs Antigen- and anti-HCV Antibody-negative Alcoholic Cirrhosis: Clinical Significance of Prior Hepatitis B Virus Infection. Alcohol Clin Exp Res. 2003;27(8 Suppl):47S-51S. PubMed PMID: 12960507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analysis of risk factors for hepatocellular carcinoma in patients with HBs antigen- and anti-HCV antibody-negative alcoholic cirrhosis: clinical significance of prior hepatitis B virus infection. AU - Uetake,Shinichiro, AU - Yamauchi,Masayoshi, AU - Itoh,Shuji, AU - Kawashima,Osamu, AU - Takeda,Kunihiko, AU - Ohata,Mitsuru, PY - 2003/9/10/pubmed PY - 2004/4/2/medline PY - 2003/9/10/entrez SP - 47S EP - 51S JF - Alcoholism, clinical and experimental research JO - Alcohol. Clin. Exp. Res. VL - 27 IS - 8 Suppl N2 - BACKGROUND: The hepatitis B virus (HBV) or hepatitis C virus (HCV) markers frequently are detected in alcoholic patients with hepatocellular carcinoma (HCC). However, risk factors for the development of HCC in patients with HBs antigen (Ag)- and anti-HCV antibody (anti-HCV)-negative alcoholic cirrhosis have not been clearly documented. The present study was conducted to elucidate the occurrence rates of HCC in HBs Ag- and anti-HCV-negative male alcoholic cirrhosis and to assess the risk factors for hepatocellular carcinogenesis. METHOD: We prospectively studied 91 consecutive patients with HBs Ag- and anti-HCV-negative alcoholic cirrhosis for 0.5 to 12.5 years (median 5.9 years). Potential risk factors assessed for liver carcinogenesis included the following six variables: age, total alcohol intake, association of continuing alcohol intake after diagnosis, indocyanine green retention rate at 15 min, anti-HB core antibodies (anti-HBc), and association of diabetes mellitus. RESULTS: Cumulative occurrence rates of HCC were 6.4%, 18.9%, and 28.7% at the end of the 5th, 7th and 10th years, respectively. When classified by anti-HBc, the occurrence rates of HCC in 31 patients with anti-HBc and 60 patients without anti-HBc were 15.6% and 2.9% at the 5th year, 28.4% and 13.5% at the 7th year, and 40.4% and 22.1% at the 10th year, respectively. The occurrence rates of HCC were also significantly related to the cumulative alcohol intake. Cox proportional hazard model identified that cumulative alcohol intake (p = 0.0047) and positive anti-HBc antibodies (p = 0.0598) were independently associated with the occurrence rates of HCC. CONCLUSION: These epidemiologic results suggest that heavy cumulative alcohol intake and prior exposure to HBV infection are risk factors for the development of HCC in patients with HBs Ag- and anti-HCV-negative alcoholic cirrhosis. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/12960507/Analysis_of_risk_factors_for_hepatocellular_carcinoma_in_patients_with_HBs_antigen__and_anti_HCV_antibody_negative_alcoholic_cirrhosis:_clinical_significance_of_prior_hepatitis_B_virus_infection_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0145-6008&date=2003&volume=27&issue=8 Suppl&spage=47S DB - PRIME DP - Unbound Medicine ER -