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G-protein alpha-subunit levels in hippocampus and entorhinal cortex of brains staged for Alzheimer's disease neurofibrillary and amyloid pathologies.
Neuroreport. 2003 Aug 06; 14(11):1523-7.N

Abstract

G-protein alpha-subunits (Galphao, Galphai, Galphas, Galphaq) and adenylyl cyclase (AC) I and II isoforms were quantified in hippocampus and entorhinal cortex from 22 cases staged for Alzheimer's disease (AD) pathologies according to Braak and Braak. Hippocampal Galphai levels declined significantly with neurofibrillary staging, whereas AC I levels in this region increased. Significant amyloid stage-related reductions of Galphai were seen in both the hippocampus and entorhinal cortex. The hippocampus also showed a significant reduction of Galphao with amyloid staging. It is concluded that levels of inhibitory G-protein subunits Galphao, and in particular Galphai, decrease in parallel to the extent of AD pathology.

Authors+Show Affiliations

Neurotec Department, Division of Experimental Geriatrics, Karolinska Institutet, Novum, KFC, S-141 86 Huddinge, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12960778

Citation

García-Jiménez, Angela, et al. "G-protein Alpha-subunit Levels in Hippocampus and Entorhinal Cortex of Brains Staged for Alzheimer's Disease Neurofibrillary and Amyloid Pathologies." Neuroreport, vol. 14, no. 11, 2003, pp. 1523-7.
García-Jiménez A, Fastbom J, Ohm TG, et al. G-protein alpha-subunit levels in hippocampus and entorhinal cortex of brains staged for Alzheimer's disease neurofibrillary and amyloid pathologies. Neuroreport. 2003;14(11):1523-7.
García-Jiménez, A., Fastbom, J., Ohm, T. G., & Cowburn, R. F. (2003). G-protein alpha-subunit levels in hippocampus and entorhinal cortex of brains staged for Alzheimer's disease neurofibrillary and amyloid pathologies. Neuroreport, 14(11), 1523-7.
García-Jiménez A, et al. G-protein Alpha-subunit Levels in Hippocampus and Entorhinal Cortex of Brains Staged for Alzheimer's Disease Neurofibrillary and Amyloid Pathologies. Neuroreport. 2003 Aug 6;14(11):1523-7. PubMed PMID: 12960778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - G-protein alpha-subunit levels in hippocampus and entorhinal cortex of brains staged for Alzheimer's disease neurofibrillary and amyloid pathologies. AU - García-Jiménez,Angela, AU - Fastbom,Johan, AU - Ohm,Thomas G, AU - Cowburn,Richard F, PY - 2003/9/10/pubmed PY - 2003/12/3/medline PY - 2003/9/10/entrez SP - 1523 EP - 7 JF - Neuroreport JO - Neuroreport VL - 14 IS - 11 N2 - G-protein alpha-subunits (Galphao, Galphai, Galphas, Galphaq) and adenylyl cyclase (AC) I and II isoforms were quantified in hippocampus and entorhinal cortex from 22 cases staged for Alzheimer's disease (AD) pathologies according to Braak and Braak. Hippocampal Galphai levels declined significantly with neurofibrillary staging, whereas AC I levels in this region increased. Significant amyloid stage-related reductions of Galphai were seen in both the hippocampus and entorhinal cortex. The hippocampus also showed a significant reduction of Galphao with amyloid staging. It is concluded that levels of inhibitory G-protein subunits Galphao, and in particular Galphai, decrease in parallel to the extent of AD pathology. SN - 0959-4965 UR - https://www.unboundmedicine.com/medline/citation/12960778/G_protein_alpha_subunit_levels_in_hippocampus_and_entorhinal_cortex_of_brains_staged_for_Alzheimer's_disease_neurofibrillary_and_amyloid_pathologies_ L2 - http://dx.doi.org/10.1097/00001756-200308060-00025 DB - PRIME DP - Unbound Medicine ER -