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Maternal serum and umbilical cord blood leptin concentrations with fetal growth restriction.
Obstet Gynecol 2003; 102(3):535-43OG

Abstract

OBJECTIVE

To ascertain whether fetal growth restriction is associated with alterations of leptin concentrations in umbilical cord blood and maternal serum.

METHODS

Maternal serum and umbilical cord blood leptin concentrations were determined by immunoradiometric assay at term in 43 women with uncomplicated singleton pregnancies (group A) and in 27 women with singleton pregnancies complicated by fetal growth restriction (group B), all with normal pregravid body mass index (BMI).

RESULTS

Maternal serum leptin concentrations were significantly higher in group B compared with group A (45.0 ng/mL [range 34.2-54.9] versus 29.0 ng/mL [range 24.7-33.3]; P<.01). Umbilical cord blood leptin levels were significantly lower in group B compared with group A (8.4 ng/mL [range 3.6-13.2] versus 13.1 ng/mL [9.7-16.5]; P<.01). Maternal serum leptin levels were not significantly correlated with maternal BMI or with neonatal birth weight in either group. Umbilical cord blood leptin concentrations were significantly correlated with neonatal birth weight in both groups.

CONCLUSION

Growth restricted fetuses at term show umbilical cord blood leptin concentrations significantly lower than those in normal fetuses, suggesting that fetal adipose tissue is a major source of leptin. Maternal serum leptin concentrations are higher in the presence of a growth restricted fetus. This increase might be due to an intrinsic placental mechanism, by which small placentas produce more leptin as a compensatory mechanism, or to early hypoxia.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, University of Naples Federico II, Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12962938

Citation

Pighetti, Marcella, et al. "Maternal Serum and Umbilical Cord Blood Leptin Concentrations With Fetal Growth Restriction." Obstetrics and Gynecology, vol. 102, no. 3, 2003, pp. 535-43.
Pighetti M, Tommaselli GA, D'Elia A, et al. Maternal serum and umbilical cord blood leptin concentrations with fetal growth restriction. Obstet Gynecol. 2003;102(3):535-43.
Pighetti, M., Tommaselli, G. A., D'Elia, A., Di Carlo, C., Mariano, A., Di Carlo, A., & Nappi, C. (2003). Maternal serum and umbilical cord blood leptin concentrations with fetal growth restriction. Obstetrics and Gynecology, 102(3), pp. 535-43.
Pighetti M, et al. Maternal Serum and Umbilical Cord Blood Leptin Concentrations With Fetal Growth Restriction. Obstet Gynecol. 2003;102(3):535-43. PubMed PMID: 12962938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal serum and umbilical cord blood leptin concentrations with fetal growth restriction. AU - Pighetti,Marcella, AU - Tommaselli,Giovanni A, AU - D'Elia,Antonio, AU - Di Carlo,Costantino, AU - Mariano,Angela, AU - Di Carlo,Angela, AU - Nappi,Carmine, PY - 2003/9/10/pubmed PY - 2003/10/16/medline PY - 2003/9/10/entrez SP - 535 EP - 43 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 102 IS - 3 N2 - OBJECTIVE: To ascertain whether fetal growth restriction is associated with alterations of leptin concentrations in umbilical cord blood and maternal serum. METHODS: Maternal serum and umbilical cord blood leptin concentrations were determined by immunoradiometric assay at term in 43 women with uncomplicated singleton pregnancies (group A) and in 27 women with singleton pregnancies complicated by fetal growth restriction (group B), all with normal pregravid body mass index (BMI). RESULTS: Maternal serum leptin concentrations were significantly higher in group B compared with group A (45.0 ng/mL [range 34.2-54.9] versus 29.0 ng/mL [range 24.7-33.3]; P<.01). Umbilical cord blood leptin levels were significantly lower in group B compared with group A (8.4 ng/mL [range 3.6-13.2] versus 13.1 ng/mL [9.7-16.5]; P<.01). Maternal serum leptin levels were not significantly correlated with maternal BMI or with neonatal birth weight in either group. Umbilical cord blood leptin concentrations were significantly correlated with neonatal birth weight in both groups. CONCLUSION: Growth restricted fetuses at term show umbilical cord blood leptin concentrations significantly lower than those in normal fetuses, suggesting that fetal adipose tissue is a major source of leptin. Maternal serum leptin concentrations are higher in the presence of a growth restricted fetus. This increase might be due to an intrinsic placental mechanism, by which small placentas produce more leptin as a compensatory mechanism, or to early hypoxia. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/12962938/Maternal_serum_and_umbilical_cord_blood_leptin_concentrations_with_fetal_growth_restriction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0029784403006689 DB - PRIME DP - Unbound Medicine ER -