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Presence of human immunodeficiency virus-1-specific CD4 and CD8 cellular immune responses in children with full or partial virus suppression.
J Infect Dis. 2003 Sep 15; 188(6):873-82.JI

Abstract

The present study assessed antiviral T cell immune responses in 48 human immunodeficiency virus (HIV)-infected children with a stable or decreasing CD4(+) T cell counts and different levels of viral control, in the presence or absence of antiretroviral therapy. Children with full (<40 copies/mL) or partial (<50,000 copies/mL) virus suppression and with a history of stable CD4(+) T cell counts had significantly increased levels of anti-HIV CD4(+) T cell lymphoproliferative responses, lower levels of CD38(+), and higher CD8(+)/CD28(+) T cell percentage, compared with those in treated children with a lack of virus suppression (>50,000 copies/mL). Levels of anti-HIV CD8(+) T cell activity, although higher in treated children with a lack of virus suppression, were not significantly different between the groups. Although levels of anti-HIV CD4(+) and CD8(+) T cell responses were not associated, these levels of responses were associated with the percentage of specific T cell subsets. Overall, a history of stable CD4(+) T cell counts, as a result of therapy that imparted full or partial virus suppression, was associated with increased levels of anti-HIV CD4(+) T helper responses and decreased T cell activation.

Authors+Show Affiliations

The Wistar Institute, Philadelphia, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12964119

Citation

Papasavvas, Emmanouil, et al. "Presence of Human Immunodeficiency Virus-1-specific CD4 and CD8 Cellular Immune Responses in Children With Full or Partial Virus Suppression." The Journal of Infectious Diseases, vol. 188, no. 6, 2003, pp. 873-82.
Papasavvas E, Sandberg JK, Rutstein R, et al. Presence of human immunodeficiency virus-1-specific CD4 and CD8 cellular immune responses in children with full or partial virus suppression. J Infect Dis. 2003;188(6):873-82.
Papasavvas, E., Sandberg, J. K., Rutstein, R., Moore, E. C., Mackiewicz, A., Thiel, B., Pistilli, M., June, R. R., Jordan, K. A., Gross, R., Maino, V. C., Nixon, D. F., & Montaner, L. J. (2003). Presence of human immunodeficiency virus-1-specific CD4 and CD8 cellular immune responses in children with full or partial virus suppression. The Journal of Infectious Diseases, 188(6), 873-82.
Papasavvas E, et al. Presence of Human Immunodeficiency Virus-1-specific CD4 and CD8 Cellular Immune Responses in Children With Full or Partial Virus Suppression. J Infect Dis. 2003 Sep 15;188(6):873-82. PubMed PMID: 12964119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Presence of human immunodeficiency virus-1-specific CD4 and CD8 cellular immune responses in children with full or partial virus suppression. AU - Papasavvas,Emmanouil, AU - Sandberg,Johan K, AU - Rutstein,Richard, AU - Moore,Elizabeth C, AU - Mackiewicz,Agnieszka, AU - Thiel,Brian, AU - Pistilli,Maxwell, AU - June,Rayford R, AU - Jordan,Kimberly A, AU - Gross,Robert, AU - Maino,Vernon C, AU - Nixon,Douglas F, AU - Montaner,Luis J, Y1 - 2003/09/04/ PY - 2003/02/07/received PY - 2003/04/10/accepted PY - 2003/9/10/pubmed PY - 2003/10/16/medline PY - 2003/9/10/entrez SP - 873 EP - 82 JF - The Journal of infectious diseases JO - J Infect Dis VL - 188 IS - 6 N2 - The present study assessed antiviral T cell immune responses in 48 human immunodeficiency virus (HIV)-infected children with a stable or decreasing CD4(+) T cell counts and different levels of viral control, in the presence or absence of antiretroviral therapy. Children with full (<40 copies/mL) or partial (<50,000 copies/mL) virus suppression and with a history of stable CD4(+) T cell counts had significantly increased levels of anti-HIV CD4(+) T cell lymphoproliferative responses, lower levels of CD38(+), and higher CD8(+)/CD28(+) T cell percentage, compared with those in treated children with a lack of virus suppression (>50,000 copies/mL). Levels of anti-HIV CD8(+) T cell activity, although higher in treated children with a lack of virus suppression, were not significantly different between the groups. Although levels of anti-HIV CD4(+) and CD8(+) T cell responses were not associated, these levels of responses were associated with the percentage of specific T cell subsets. Overall, a history of stable CD4(+) T cell counts, as a result of therapy that imparted full or partial virus suppression, was associated with increased levels of anti-HIV CD4(+) T helper responses and decreased T cell activation. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/12964119/Presence_of_human_immunodeficiency_virus_1_specific_CD4_and_CD8_cellular_immune_responses_in_children_with_full_or_partial_virus_suppression_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/377645 DB - PRIME DP - Unbound Medicine ER -