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Markers of hepatitis B infection in Tari District, Southern Highlands Province, Papua New Guinea.
P N G Med J. 1992 Sep; 35(3):197-201.PN

Abstract

Serum samples collected from two groups in the Tari District of Southern Highlands Province were assayed for markers of hepatitis B virus (HBV) infection. 85% of women of childbearing age were found to have markers of HBV infection; 37% were positive for HBV surface antigen (HBsAg), indicative of the chronic carrier state, and 6.6% were positive for HBV e antigen (HBeAg), indicating the presence of actively replicating virus. 75% of women negative for HBsAg were positive for antibody to HBV core antigen (HBcAb), a marker of past infection. A group of children aged 6 to 18 years showed a significantly lower prevalence of markers of infection (66%) but higher rates of HBsAg positivity (46%) and HBeAg positivity (30%). Only 37% of the HBsAg-negative children in this group were positive for HBcAb. The results from this serosurvey suggest that the major route of HBV transmission in this population is horizontal, between older children, though significant transmission also occurs during the neonatal period.

Authors+Show Affiliations

Papua New Guinea Institute of Medical Research, Goroka.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1296422

Citation

Sanders, R C., et al. "Markers of Hepatitis B Infection in Tari District, Southern Highlands Province, Papua New Guinea." Papua and New Guinea Medical Journal, vol. 35, no. 3, 1992, pp. 197-201.
Sanders RC, Lewis D, Dyke T, et al. Markers of hepatitis B infection in Tari District, Southern Highlands Province, Papua New Guinea. P N G Med J. 1992;35(3):197-201.
Sanders, R. C., Lewis, D., Dyke, T., & Alpers, M. P. (1992). Markers of hepatitis B infection in Tari District, Southern Highlands Province, Papua New Guinea. Papua and New Guinea Medical Journal, 35(3), 197-201.
Sanders RC, et al. Markers of Hepatitis B Infection in Tari District, Southern Highlands Province, Papua New Guinea. P N G Med J. 1992;35(3):197-201. PubMed PMID: 1296422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Markers of hepatitis B infection in Tari District, Southern Highlands Province, Papua New Guinea. AU - Sanders,R C, AU - Lewis,D, AU - Dyke,T, AU - Alpers,M P, PY - 1992/9/1/pubmed PY - 1992/9/1/medline PY - 1992/9/1/entrez KW - Age Factors KW - Antibodies KW - Antigen-antibody Reactions KW - Biology KW - Child KW - Demographic Factors KW - Developing Countries KW - Diseases KW - Examinations And Diagnoses KW - Hematologic Tests KW - Hepatitis KW - Immunity KW - Immunologic Factors KW - Laboratory Examinations And Diagnoses KW - Laboratory Procedures KW - Melanesia KW - Oceania KW - Papua New Guinea KW - Physiology KW - Population KW - Population Characteristics KW - Research Report KW - Screening KW - Viral Diseases KW - Youth SP - 197 EP - 201 JF - Papua and New Guinea medical journal JO - P N G Med J VL - 35 IS - 3 N2 - Serum samples collected from two groups in the Tari District of Southern Highlands Province were assayed for markers of hepatitis B virus (HBV) infection. 85% of women of childbearing age were found to have markers of HBV infection; 37% were positive for HBV surface antigen (HBsAg), indicative of the chronic carrier state, and 6.6% were positive for HBV e antigen (HBeAg), indicating the presence of actively replicating virus. 75% of women negative for HBsAg were positive for antibody to HBV core antigen (HBcAb), a marker of past infection. A group of children aged 6 to 18 years showed a significantly lower prevalence of markers of infection (66%) but higher rates of HBsAg positivity (46%) and HBeAg positivity (30%). Only 37% of the HBsAg-negative children in this group were positive for HBcAb. The results from this serosurvey suggest that the major route of HBV transmission in this population is horizontal, between older children, though significant transmission also occurs during the neonatal period. SN - 0031-1480 UR - https://www.unboundmedicine.com/medline/citation/1296422/Markers_of_hepatitis_B_infection_in_Tari_District_Southern_Highlands_Province_Papua_New_Guinea_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -