Tags

Type your tag names separated by a space and hit enter

Parkinson's disease and smoking: an integral part of PD's etiological study.
Biomed Environ Sci. 2003 Jun; 16(2):173-9.BE

Abstract

OBJECTIVE

To explore the association of Parkinson's disease (PD) with cigarette smoking.

METHODS

One hundred of fourteen PD patients were compared with 205 control subjects who were matched by gender, race and residency. A previously validated questionnaire including smoking, alcohol/tea consumption as well as some other environmental exposure data was administered.

RESULTS

With never-smokers as the reference category, we observed reduced risk for PD among ever smokers (OR=0.49, 95% CI: 0.30 to 0.79) current smokers (OR=0.44, 95% CI: 0.23 to 0.86) and ex-smokers (OR=0.54, 95% CI: 0.30 to 0.96). When ever smokers were stratified by years of smoking, there was an inverse correlation between those whose smoking history was longer than 20 years (OR=0.40 95% CI: 0.21 to 0.81) and an even mild protective correlation between those who smoked less than 20 years (OR=0.57, 95% CI: 0.33 to 0.99). Those who had quitted smoking for more than 20 years were less likely to have the disease than never smokers, and those who had quitted for less than 20 years were least likely to have PD, while those who were current smokers were still least likely to have the disease. We found significant inverse gradient with pack-day smoking (trend P<0.05), and the inverse correlation between cigarette smoking and PD was not confounded by alcohol/tea consumption and other confounding bias.

CONCLUSIONS

The inverse correlation between Parkinson's disease risk and smoking as well as the trend of gradient dose response is again observed in our study. More future researches are needed to confirm these correlations and to explore further biochemical evidence.

Authors+Show Affiliations

School of Basic Medicine, Peking Union Medical College/Chinese Academy of Medical Sciences, Beijing 100005, China. jqdong1717@163.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12964791

Citation

Dong, Jian-Qun, et al. "Parkinson's Disease and Smoking: an Integral Part of PD's Etiological Study." Biomedical and Environmental Sciences : BES, vol. 16, no. 2, 2003, pp. 173-9.
Dong JQ, Zhang ZX, Zhang KL. Parkinson's disease and smoking: an integral part of PD's etiological study. Biomed Environ Sci. 2003;16(2):173-9.
Dong, J. Q., Zhang, Z. X., & Zhang, K. L. (2003). Parkinson's disease and smoking: an integral part of PD's etiological study. Biomedical and Environmental Sciences : BES, 16(2), 173-9.
Dong JQ, Zhang ZX, Zhang KL. Parkinson's Disease and Smoking: an Integral Part of PD's Etiological Study. Biomed Environ Sci. 2003;16(2):173-9. PubMed PMID: 12964791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parkinson's disease and smoking: an integral part of PD's etiological study. AU - Dong,Jian-Qun, AU - Zhang,Zhen-Xin, AU - Zhang,Kong-Lai, PY - 2003/9/11/pubmed PY - 2004/1/31/medline PY - 2003/9/11/entrez SP - 173 EP - 9 JF - Biomedical and environmental sciences : BES JO - Biomed Environ Sci VL - 16 IS - 2 N2 - OBJECTIVE: To explore the association of Parkinson's disease (PD) with cigarette smoking. METHODS: One hundred of fourteen PD patients were compared with 205 control subjects who were matched by gender, race and residency. A previously validated questionnaire including smoking, alcohol/tea consumption as well as some other environmental exposure data was administered. RESULTS: With never-smokers as the reference category, we observed reduced risk for PD among ever smokers (OR=0.49, 95% CI: 0.30 to 0.79) current smokers (OR=0.44, 95% CI: 0.23 to 0.86) and ex-smokers (OR=0.54, 95% CI: 0.30 to 0.96). When ever smokers were stratified by years of smoking, there was an inverse correlation between those whose smoking history was longer than 20 years (OR=0.40 95% CI: 0.21 to 0.81) and an even mild protective correlation between those who smoked less than 20 years (OR=0.57, 95% CI: 0.33 to 0.99). Those who had quitted smoking for more than 20 years were less likely to have the disease than never smokers, and those who had quitted for less than 20 years were least likely to have PD, while those who were current smokers were still least likely to have the disease. We found significant inverse gradient with pack-day smoking (trend P<0.05), and the inverse correlation between cigarette smoking and PD was not confounded by alcohol/tea consumption and other confounding bias. CONCLUSIONS: The inverse correlation between Parkinson's disease risk and smoking as well as the trend of gradient dose response is again observed in our study. More future researches are needed to confirm these correlations and to explore further biochemical evidence. SN - 0895-3988 UR - https://www.unboundmedicine.com/medline/citation/12964791/Parkinson's_disease_and_smoking:_an_integral_part_of_PD's_etiological_study_ L2 - https://medlineplus.gov/parkinsonsdisease.html DB - PRIME DP - Unbound Medicine ER -