[Postprandial hyperglycemia. Postprandial blood glucose fluctuations, cardiovascular disease and late diabetic complications].Ugeskr Laeger. 2003 Aug 11; 165(33):3149-53.UL
Epidemiological studies have suggested that postprandial hyperglycaemia may be a unique risk factor for development of cardiovascular disease, although the predictive value has been minor or disappeared after compensation for other cardiovascular risk factors. Pathophysiological studies have demonstrated that acute changes in blood glucose may induce changes predisposing for development of microangiopathy in the retina, the kidneys and the nerves. Studies have also shown that postprandial hyperglycaemia may be a risk factor for the development of atherosclerosis. No randomised controlled trials have focused on specific treatment of postprandial hyperglycaemia. Therefore, the importance of postprandial hyperglycaemia for development of diabetic complications and atherosclerosis is unclear.