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Prevalence, clinical spectrum and health care utilization of gastro-oesophageal reflux disease in a Chinese population: a population-based study.

Abstract

BACKGROUND

Population-based data on gastro-oesophageal reflux disease in Chinese are lacking. The prevalence, clinical spectrum and health care-seeking behaviour of subjects with gastro-oesophageal reflux disease were studied.

METHODS

Ethnic Chinese (3605) were invited to participate in a telephone survey using a validated gastro-oesophageal reflux disease questionnaire and the Hospital Anxiety and Depression Scale.

RESULTS

A total of 2209 subjects (58% female; mean age, 40.3 years) completed the interview. The annual, monthly and weekly prevalence rates of gastro-oesophageal reflux disease were 29.8%, 8.9% and 2.5%, respectively. Gastro-oesophageal reflux disease symptoms were associated with non-cardiac chest pain [odds ratio (OR), 2.3; 95% confidence interval (95% CI), 1.7-3.1], dyspepsia (OR, 1.9; 95% CI, 1.4-2.5), globus (OR, 1.8; 95% CI, 1.2-2.7), acid feeling in the stomach (OR, 5.8; 95% CI, 4.5-7.5) and the use of non-steroidal anti-inflammatory drugs (OR, 2.3; 95% CI, 1.5-3.6), but not with dysphagia, bronchitis, asthma, hoarseness and pneumonia. Patients with gastro-oesophageal reflux disease had a significantly higher anxiety and depression score and required more days off work when compared with subjects without. The frequency of heartburn (P = 0.032), female gender (P < 0.001), degree of depression (P = 0.004) and social morbidity (P < 0.001) were independent factors associated with health care-seeking behaviour.

CONCLUSION

The prevalence of gastro-oesophageal reflux disease was lower than that in Western populations, but carried a significant socio-economic burden in the studied Chinese population. The frequency of heartburn, female gender and psychosocial factors were associated with health care utilization in gastro-oesophageal reflux disease.

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  • Authors+Show Affiliations

    ,

    Departments of Medicine and Statistics and Actuarial Science, University of Hong Kong, Hong Kong. bcywong@hku.hk

    , , , , , , , , ,

    Source

    Alimentary pharmacology & therapeutics 18:6 2003 Sep 15 pg 595-604

    MeSH

    Adult
    Aged
    Anxiety
    Chest Pain
    Chi-Square Distribution
    China
    Depression
    Dyspnea
    Female
    Gastroesophageal Reflux
    Health Services
    Health Surveys
    Humans
    Interpersonal Relations
    Male
    Middle Aged
    Patient Acceptance of Health Care
    Prevalence
    Sex Factors

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12969086

    Citation

    Wong, W M., et al. "Prevalence, Clinical Spectrum and Health Care Utilization of Gastro-oesophageal Reflux Disease in a Chinese Population: a Population-based Study." Alimentary Pharmacology & Therapeutics, vol. 18, no. 6, 2003, pp. 595-604.
    Wong WM, Lai KC, Lam KF, et al. Prevalence, clinical spectrum and health care utilization of gastro-oesophageal reflux disease in a Chinese population: a population-based study. Aliment Pharmacol Ther. 2003;18(6):595-604.
    Wong, W. M., Lai, K. C., Lam, K. F., Hui, W. M., Hu, W. H., Lam, C. L., ... Wong, B. C. (2003). Prevalence, clinical spectrum and health care utilization of gastro-oesophageal reflux disease in a Chinese population: a population-based study. Alimentary Pharmacology & Therapeutics, 18(6), pp. 595-604.
    Wong WM, et al. Prevalence, Clinical Spectrum and Health Care Utilization of Gastro-oesophageal Reflux Disease in a Chinese Population: a Population-based Study. Aliment Pharmacol Ther. 2003 Sep 15;18(6):595-604. PubMed PMID: 12969086.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Prevalence, clinical spectrum and health care utilization of gastro-oesophageal reflux disease in a Chinese population: a population-based study. AU - Wong,W M, AU - Lai,K C, AU - Lam,K F, AU - Hui,W M, AU - Hu,W H C, AU - Lam,C L K, AU - Xia,H H X, AU - Huang,J Q, AU - Chan,C K, AU - Lam,S K, AU - Wong,B C Y, PY - 2003/9/13/pubmed PY - 2003/11/7/medline PY - 2003/9/13/entrez SP - 595 EP - 604 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 18 IS - 6 N2 - BACKGROUND: Population-based data on gastro-oesophageal reflux disease in Chinese are lacking. The prevalence, clinical spectrum and health care-seeking behaviour of subjects with gastro-oesophageal reflux disease were studied. METHODS: Ethnic Chinese (3605) were invited to participate in a telephone survey using a validated gastro-oesophageal reflux disease questionnaire and the Hospital Anxiety and Depression Scale. RESULTS: A total of 2209 subjects (58% female; mean age, 40.3 years) completed the interview. The annual, monthly and weekly prevalence rates of gastro-oesophageal reflux disease were 29.8%, 8.9% and 2.5%, respectively. Gastro-oesophageal reflux disease symptoms were associated with non-cardiac chest pain [odds ratio (OR), 2.3; 95% confidence interval (95% CI), 1.7-3.1], dyspepsia (OR, 1.9; 95% CI, 1.4-2.5), globus (OR, 1.8; 95% CI, 1.2-2.7), acid feeling in the stomach (OR, 5.8; 95% CI, 4.5-7.5) and the use of non-steroidal anti-inflammatory drugs (OR, 2.3; 95% CI, 1.5-3.6), but not with dysphagia, bronchitis, asthma, hoarseness and pneumonia. Patients with gastro-oesophageal reflux disease had a significantly higher anxiety and depression score and required more days off work when compared with subjects without. The frequency of heartburn (P = 0.032), female gender (P < 0.001), degree of depression (P = 0.004) and social morbidity (P < 0.001) were independent factors associated with health care-seeking behaviour. CONCLUSION: The prevalence of gastro-oesophageal reflux disease was lower than that in Western populations, but carried a significant socio-economic burden in the studied Chinese population. The frequency of heartburn, female gender and psychosocial factors were associated with health care utilization in gastro-oesophageal reflux disease. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/12969086/Prevalence_clinical_spectrum_and_health_care_utilization_of_gastro_oesophageal_reflux_disease_in_a_Chinese_population:_a_population_based_study_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0269-2813&amp;date=2003&amp;volume=18&amp;issue=6&amp;spage=595 DB - PRIME DP - Unbound Medicine ER -