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Nicotinamide adenine dinucleotide (phosphate) reduced:quinone oxidoreductase and glutathione S-transferase M1 polymorphisms and childhood asthma.
Am J Respir Crit Care Med. 2003 Nov 15; 168(10):1199-204.AJ

Abstract

Nicotinamide adenine dinucleotide (phosphate) reduced:quinone oxidoreductase (NQO1) and glutathione S-transferase (GST) M1 are phase II enzymes important in response to oxidative stress, such as occurs during exposure to ozone. We examined the relationship between functionally significant polymorphisms in NQO1 (Pro187Ser) and GSTM1 (homozygous deletion) and asthma risk in children with high lifetime exposure to ozone. We enrolled children with asthma from the allergy referral clinic at a public pediatric hospital in Mexico City, together with their parents. We assayed for the Pro187Ser polymorphism in NQO1 using a polymerase chain reaction-restriction fragment length polymorphism assay and for the presence of GSTM1 by polymerase chain reaction among 218 case-parent triads. We did not find strong evidence of an association between NQO1 genotype alone and asthma risk. However, among subjects with homozygous deletion of GSTM1, carriers of a serine allele were at significantly reduced risk of asthma compared with Pro/Pro homozygotes (relative risk = 0.4; 95% confidence interval, 0.2-0.8). The p value for difference in relative risk for NQO1 by GSTM1 genotype = 0.013. These data are consistent with a protective effect of the NQO1 Ser allele in this population of GSTM1-null children with high ozone exposure.

Authors+Show Affiliations

National Institute of Environmental Health Sciences, PO Box 12233, MD D2-01, Research Triangle Park, NC 27709, USA. davidbe1@niehs.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12969868

Citation

David, Gloria L., et al. "Nicotinamide Adenine Dinucleotide (phosphate) Reduced:quinone Oxidoreductase and Glutathione S-transferase M1 Polymorphisms and Childhood Asthma." American Journal of Respiratory and Critical Care Medicine, vol. 168, no. 10, 2003, pp. 1199-204.
David GL, Romieu I, Sienra-Monge JJ, et al. Nicotinamide adenine dinucleotide (phosphate) reduced:quinone oxidoreductase and glutathione S-transferase M1 polymorphisms and childhood asthma. Am J Respir Crit Care Med. 2003;168(10):1199-204.
David, G. L., Romieu, I., Sienra-Monge, J. J., Collins, W. J., Ramirez-Aguilar, M., del Rio-Navarro, B. E., Reyes-Ruiz, N. I., Morris, R. W., Marzec, J. M., & London, S. J. (2003). Nicotinamide adenine dinucleotide (phosphate) reduced:quinone oxidoreductase and glutathione S-transferase M1 polymorphisms and childhood asthma. American Journal of Respiratory and Critical Care Medicine, 168(10), 1199-204.
David GL, et al. Nicotinamide Adenine Dinucleotide (phosphate) Reduced:quinone Oxidoreductase and Glutathione S-transferase M1 Polymorphisms and Childhood Asthma. Am J Respir Crit Care Med. 2003 Nov 15;168(10):1199-204. PubMed PMID: 12969868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nicotinamide adenine dinucleotide (phosphate) reduced:quinone oxidoreductase and glutathione S-transferase M1 polymorphisms and childhood asthma. AU - David,Gloria L, AU - Romieu,Isabelle, AU - Sienra-Monge,Juan Jose, AU - Collins,William J, AU - Ramirez-Aguilar,Matiana, AU - del Rio-Navarro,Blanca Estela, AU - Reyes-Ruiz,Norma Isabel, AU - Morris,Richard W, AU - Marzec,Jacqueline M, AU - London,Stephanie J, Y1 - 2003/09/11/ PY - 2003/9/13/pubmed PY - 2003/12/24/medline PY - 2003/9/13/entrez SP - 1199 EP - 204 JF - American journal of respiratory and critical care medicine JO - Am J Respir Crit Care Med VL - 168 IS - 10 N2 - Nicotinamide adenine dinucleotide (phosphate) reduced:quinone oxidoreductase (NQO1) and glutathione S-transferase (GST) M1 are phase II enzymes important in response to oxidative stress, such as occurs during exposure to ozone. We examined the relationship between functionally significant polymorphisms in NQO1 (Pro187Ser) and GSTM1 (homozygous deletion) and asthma risk in children with high lifetime exposure to ozone. We enrolled children with asthma from the allergy referral clinic at a public pediatric hospital in Mexico City, together with their parents. We assayed for the Pro187Ser polymorphism in NQO1 using a polymerase chain reaction-restriction fragment length polymorphism assay and for the presence of GSTM1 by polymerase chain reaction among 218 case-parent triads. We did not find strong evidence of an association between NQO1 genotype alone and asthma risk. However, among subjects with homozygous deletion of GSTM1, carriers of a serine allele were at significantly reduced risk of asthma compared with Pro/Pro homozygotes (relative risk = 0.4; 95% confidence interval, 0.2-0.8). The p value for difference in relative risk for NQO1 by GSTM1 genotype = 0.013. These data are consistent with a protective effect of the NQO1 Ser allele in this population of GSTM1-null children with high ozone exposure. SN - 1073-449X UR - https://www.unboundmedicine.com/medline/citation/12969868/Nicotinamide_adenine_dinucleotide__phosphate__reduced:quinone_oxidoreductase_and_glutathione_S_transferase_M1_polymorphisms_and_childhood_asthma_ L2 - https://www.atsjournals.org/doi/10.1164/rccm.200305-684OC?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -