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Effects of ghrelin on the insulin and glycemic responses to glucose, arginine, or free fatty acids load in humans.
J Clin Endocrinol Metab. 2003 Sep; 88(9):4268-72.JC

Abstract

Ghrelin possesses central and peripheral endocrine actions including influence on the endocrine pancreatic function. To clarify this latter ghrelin action, in seven normal young subjects [age (mean +/- SEM), 28.3 +/- 3.1 yr; body mass index, 21.9 +/- 0.9 kg/m(2)), we studied insulin and glucose levels after acute ghrelin administration (1.0 microg/kg i.v.) alone or combined with glucose [oral glucose tolerance test (OGTT), 100 g orally], arginine (ARG, 0.5 g/kg i.v.) or free fatty acid (FFA, Intralipid 10%, 250 ml). Ghrelin inhibited (P < 0.05) insulin and increased (P < 0.05) glucose levels. OGTT increased (P < 0.01) glucose and insulin levels. FFA increased (P < 0.05) glucose but did not modify insulin levels. ARG increased (P < 0.05) both insulin and glucose levels. Ghrelin did not modify both glucose and insulin responses to OGTT as well as the FFA-induced increase in glucose levels; however, ghrelin administration was followed by transient insulin decrease also during FFA. Ghrelin blunted (P < 0.05) the insulin response to ARG and enhanced (P < 0.05) the ARG-induced increase in glucose levels. In all, ghrelin induces transient decrease of spontaneous insulin secretion and selectively blunts the insulin response to ARG but not to oral glucose load. On the other hand, ghrelin raises basal glucose levels and enhances the hyperglycemic effect of ARG but not that of OGTT. These findings support the hypothesis that ghrelin exerts modulatory action of insulin secretion and glucose metabolism in humans.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, 10126 Torino, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12970297

Citation

Broglio, F, et al. "Effects of Ghrelin On the Insulin and Glycemic Responses to Glucose, Arginine, or Free Fatty Acids Load in Humans." The Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 9, 2003, pp. 4268-72.
Broglio F, Gottero C, Benso A, et al. Effects of ghrelin on the insulin and glycemic responses to glucose, arginine, or free fatty acids load in humans. J Clin Endocrinol Metab. 2003;88(9):4268-72.
Broglio, F., Gottero, C., Benso, A., Prodam, F., Destefanis, S., Gauna, C., Maccario, M., Deghenghi, R., van der Lely, A. J., & Ghigo, E. (2003). Effects of ghrelin on the insulin and glycemic responses to glucose, arginine, or free fatty acids load in humans. The Journal of Clinical Endocrinology and Metabolism, 88(9), 4268-72.
Broglio F, et al. Effects of Ghrelin On the Insulin and Glycemic Responses to Glucose, Arginine, or Free Fatty Acids Load in Humans. J Clin Endocrinol Metab. 2003;88(9):4268-72. PubMed PMID: 12970297.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of ghrelin on the insulin and glycemic responses to glucose, arginine, or free fatty acids load in humans. AU - Broglio,F, AU - Gottero,C, AU - Benso,A, AU - Prodam,F, AU - Destefanis,S, AU - Gauna,C, AU - Maccario,M, AU - Deghenghi,R, AU - van der Lely,A J, AU - Ghigo,E, PY - 2003/9/13/pubmed PY - 2003/10/11/medline PY - 2003/9/13/entrez SP - 4268 EP - 72 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 88 IS - 9 N2 - Ghrelin possesses central and peripheral endocrine actions including influence on the endocrine pancreatic function. To clarify this latter ghrelin action, in seven normal young subjects [age (mean +/- SEM), 28.3 +/- 3.1 yr; body mass index, 21.9 +/- 0.9 kg/m(2)), we studied insulin and glucose levels after acute ghrelin administration (1.0 microg/kg i.v.) alone or combined with glucose [oral glucose tolerance test (OGTT), 100 g orally], arginine (ARG, 0.5 g/kg i.v.) or free fatty acid (FFA, Intralipid 10%, 250 ml). Ghrelin inhibited (P < 0.05) insulin and increased (P < 0.05) glucose levels. OGTT increased (P < 0.01) glucose and insulin levels. FFA increased (P < 0.05) glucose but did not modify insulin levels. ARG increased (P < 0.05) both insulin and glucose levels. Ghrelin did not modify both glucose and insulin responses to OGTT as well as the FFA-induced increase in glucose levels; however, ghrelin administration was followed by transient insulin decrease also during FFA. Ghrelin blunted (P < 0.05) the insulin response to ARG and enhanced (P < 0.05) the ARG-induced increase in glucose levels. In all, ghrelin induces transient decrease of spontaneous insulin secretion and selectively blunts the insulin response to ARG but not to oral glucose load. On the other hand, ghrelin raises basal glucose levels and enhances the hyperglycemic effect of ARG but not that of OGTT. These findings support the hypothesis that ghrelin exerts modulatory action of insulin secretion and glucose metabolism in humans. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/12970297/Effects_of_ghrelin_on_the_insulin_and_glycemic_responses_to_glucose_arginine_or_free_fatty_acids_load_in_humans_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2002-021940 DB - PRIME DP - Unbound Medicine ER -