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Dietary magnesium intake and the future risk of coronary heart disease (the Honolulu Heart Program).
Am J Cardiol 2003; 92(6):665-9AJ

Abstract

Magnesium (Mg) deficiency is believed to have adverse cardiovascular consequences that are broad and complex, although an association between dietary Mg intake and the risk of coronary heart disease (CHD) has not been clearly identified. The purpose of this study is to examine the relation between dietary Mg intake and future risk of CHD. Reported findings are based on dietary Mg intake in 7,172 men in the Honolulu Heart Program. Intake of Mg was recorded at baseline examinations that took place from 1965 to 1968 when the men were aged 45 to 68 years. In 30 years of follow-up, 1,431 incident cases of CHD were identified. Within 15 years after dietary assessment, the age-adjusted incidence decreased significantly from 7.3 to 4.0 per 1,000 person-years in the lowest (50.3 to 186 mg/day) versus highest (340 to 1,183 mg/day) quintiles of Mg intake (p <0.001). When adjustments were made for age and other nutrients (singly or combined), there was a 1.7- to 2.1-fold excess in the risk of CHD in the lowest versus highest quintiles (p <0.001). The excess risk ranged from 1.5- to 1.8-fold after further adjustment for other cardiovascular risk factors (p <0.05). Associations between dietary Mg and coronary events occurring after 15 years of follow-up were modest. We conclude that the intake of dietary Mg is associated with a reduced risk of CHD. Whether increases in dietary Mg intake can alter the future risk of disease warrants further study.

Authors+Show Affiliations

Division of Biostatistics and Epidemiology, Department of Health Evaluation Sciences, University of Virginia School of Medicine, PO Box 800717, Charlottesville, VA 22908-0717, USA. rda3e@virginia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12972103

Citation

Abbott, Robert D., et al. "Dietary Magnesium Intake and the Future Risk of Coronary Heart Disease (the Honolulu Heart Program)." The American Journal of Cardiology, vol. 92, no. 6, 2003, pp. 665-9.
Abbott RD, Ando F, Masaki KH, et al. Dietary magnesium intake and the future risk of coronary heart disease (the Honolulu Heart Program). Am J Cardiol. 2003;92(6):665-9.
Abbott, R. D., Ando, F., Masaki, K. H., Tung, K. H., Rodriguez, B. L., Petrovitch, H., ... Curb, J. D. (2003). Dietary magnesium intake and the future risk of coronary heart disease (the Honolulu Heart Program). The American Journal of Cardiology, 92(6), pp. 665-9.
Abbott RD, et al. Dietary Magnesium Intake and the Future Risk of Coronary Heart Disease (the Honolulu Heart Program). Am J Cardiol. 2003 Sep 15;92(6):665-9. PubMed PMID: 12972103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary magnesium intake and the future risk of coronary heart disease (the Honolulu Heart Program). AU - Abbott,Robert D, AU - Ando,Fujiko, AU - Masaki,Kamal H, AU - Tung,Ko-Hui, AU - Rodriguez,Beatriz L, AU - Petrovitch,Helen, AU - Yano,Katsuhiko, AU - Curb,J David, PY - 2003/9/16/pubmed PY - 2003/12/13/medline PY - 2003/9/16/entrez SP - 665 EP - 9 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 92 IS - 6 N2 - Magnesium (Mg) deficiency is believed to have adverse cardiovascular consequences that are broad and complex, although an association between dietary Mg intake and the risk of coronary heart disease (CHD) has not been clearly identified. The purpose of this study is to examine the relation between dietary Mg intake and future risk of CHD. Reported findings are based on dietary Mg intake in 7,172 men in the Honolulu Heart Program. Intake of Mg was recorded at baseline examinations that took place from 1965 to 1968 when the men were aged 45 to 68 years. In 30 years of follow-up, 1,431 incident cases of CHD were identified. Within 15 years after dietary assessment, the age-adjusted incidence decreased significantly from 7.3 to 4.0 per 1,000 person-years in the lowest (50.3 to 186 mg/day) versus highest (340 to 1,183 mg/day) quintiles of Mg intake (p <0.001). When adjustments were made for age and other nutrients (singly or combined), there was a 1.7- to 2.1-fold excess in the risk of CHD in the lowest versus highest quintiles (p <0.001). The excess risk ranged from 1.5- to 1.8-fold after further adjustment for other cardiovascular risk factors (p <0.05). Associations between dietary Mg and coronary events occurring after 15 years of follow-up were modest. We conclude that the intake of dietary Mg is associated with a reduced risk of CHD. Whether increases in dietary Mg intake can alter the future risk of disease warrants further study. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/12972103/Dietary_magnesium_intake_and_the_future_risk_of_coronary_heart_disease__the_Honolulu_Heart_Program__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002914903008191 DB - PRIME DP - Unbound Medicine ER -