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Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance.
Obes Res. 2003 Sep; 11(9):1048-54.OR

Abstract

OBJECTIVE

To study the effect of weight loss in response to a lifestyle modification program on the circulating levels of adipose tissue derived cytokines (adipokines) in obese individuals with insulin resistance.

RESEARCH METHODS AND PROCEDURES

Twenty-four insulin-resistant obese subjects with varying degrees of glucose tolerance completed a 6-month program consisting of combined hypocaloric diet and moderate physical activity. Adipokines [leptin, adiponectin, resistin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6)] and highly sensitive C-reactive protein were measured before and after the intervention. Insulin sensitivity index was evaluated by the frequently sampled intravenous glucose tolerance test.

RESULTS

Participants had a 6.9 +/- 0.1 kg average weight loss, with a significant improvement in sensitivity index and reduction in plasma leptin (27.8 +/- 3 vs. 23.6 +/- 3 ng/mL, p = 0.01) and IL-6 (2.75 +/- 1.51 vs. 2.3 +/- 0.91 pg/mL, p = 0.012). TNF-alpha levels tended to decrease (2.3 +/- 0.2 vs. 1.9 +/- 0.1 pg/mL, p = 0.059). Adiponectin increased significantly only among diabetic subjects. The reductions in leptin were correlated with the decreases in BMI (r = 0.464, p < 0.05) and with changes in highly sensitive C-reactive protein (r = 0.466, p < 0.05).

DISCUSSION

Weight reduction in obese individuals with insulin resistance was associated with a significant decrease in leptin and IL-6 and a tendency toward a decrease in circulating TNF-alpha, whereas adiponectin was increased only in diabetic subjects. Further studies are needed to elucidate the relationship between changes of adipokines and the health benefits of weight loss.

Authors+Show Affiliations

Clinical Research Center, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12972674

Citation

Monzillo, Lais U., et al. "Effect of Lifestyle Modification On Adipokine Levels in Obese Subjects With Insulin Resistance." Obesity Research, vol. 11, no. 9, 2003, pp. 1048-54.
Monzillo LU, Hamdy O, Horton ES, et al. Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. Obes Res. 2003;11(9):1048-54.
Monzillo, L. U., Hamdy, O., Horton, E. S., Ledbury, S., Mullooly, C., Jarema, C., Porter, S., Ovalle, K., Moussa, A., & Mantzoros, C. S. (2003). Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. Obesity Research, 11(9), 1048-54.
Monzillo LU, et al. Effect of Lifestyle Modification On Adipokine Levels in Obese Subjects With Insulin Resistance. Obes Res. 2003;11(9):1048-54. PubMed PMID: 12972674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. AU - Monzillo,Lais U, AU - Hamdy,Osama, AU - Horton,Edward S, AU - Ledbury,Sarah, AU - Mullooly,Cathy, AU - Jarema,Catherine, AU - Porter,Satoko, AU - Ovalle,Kerry, AU - Moussa,Amr, AU - Mantzoros,Christos S, PY - 2003/9/16/pubmed PY - 2004/2/6/medline PY - 2003/9/16/entrez SP - 1048 EP - 54 JF - Obesity research JO - Obes Res VL - 11 IS - 9 N2 - OBJECTIVE: To study the effect of weight loss in response to a lifestyle modification program on the circulating levels of adipose tissue derived cytokines (adipokines) in obese individuals with insulin resistance. RESEARCH METHODS AND PROCEDURES: Twenty-four insulin-resistant obese subjects with varying degrees of glucose tolerance completed a 6-month program consisting of combined hypocaloric diet and moderate physical activity. Adipokines [leptin, adiponectin, resistin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6)] and highly sensitive C-reactive protein were measured before and after the intervention. Insulin sensitivity index was evaluated by the frequently sampled intravenous glucose tolerance test. RESULTS: Participants had a 6.9 +/- 0.1 kg average weight loss, with a significant improvement in sensitivity index and reduction in plasma leptin (27.8 +/- 3 vs. 23.6 +/- 3 ng/mL, p = 0.01) and IL-6 (2.75 +/- 1.51 vs. 2.3 +/- 0.91 pg/mL, p = 0.012). TNF-alpha levels tended to decrease (2.3 +/- 0.2 vs. 1.9 +/- 0.1 pg/mL, p = 0.059). Adiponectin increased significantly only among diabetic subjects. The reductions in leptin were correlated with the decreases in BMI (r = 0.464, p < 0.05) and with changes in highly sensitive C-reactive protein (r = 0.466, p < 0.05). DISCUSSION: Weight reduction in obese individuals with insulin resistance was associated with a significant decrease in leptin and IL-6 and a tendency toward a decrease in circulating TNF-alpha, whereas adiponectin was increased only in diabetic subjects. Further studies are needed to elucidate the relationship between changes of adipokines and the health benefits of weight loss. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/12972674/Effect_of_lifestyle_modification_on_adipokine_levels_in_obese_subjects_with_insulin_resistance_ L2 - https://doi.org/10.1038/oby.2003.144 DB - PRIME DP - Unbound Medicine ER -