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Decrease in serum adiponectin level due to obesity and visceral fat accumulation in children.
Obes Res. 2003 Sep; 11(9):1072-9.OR

Abstract

OBJECTIVE

To determine whether serum adiponectin is decreased in obesity and is restored toward normal level after treatment in children.

RESEARCH METHODS AND PROCEDURES

Subjects were 53 Japanese obese children, 33 boys and 20 girls (6 to 14 years old), and 30 age-matched nonobese controls for measuring adiponectin (16 boys and 14 girls). Blood was drawn after an overnight fast, and the obese children were subjected to anthropometric measurements including waist and hip circumferences and skinfold thicknesses. Paired samples were obtained from 21 obese children who underwent psychoeducational therapy. Visceral adipose tissue area was measured by computed tomography. Adiponectin was assayed by an enzyme-linked immunosorbent assay.

RESULTS

The serum levels of alanine aminotransferase, uric acid, triglyceride, total cholesterol, low-density lipoprotein-cholesterol, total cholesterol/high-density lipoprotein-cholesterol, apo B, apo B/apo A(1), and insulin in obese children were higher than the reference values. Serum adiponectin level was lower in the obese children than in the controls (6.4 +/- 0.6 vs. 10.2 +/- 0.8 mg/L, means +/- SEM, p < 0.001). In 21 obese children whose percent overweight declined during therapy, the adiponectin level increased (p = 0.002). The adiponectin level was correlated inversely with visceral adipose tissue area in obese children (r = -0.531, p < 0.001). The inverse correlations of adiponectin with alanine aminotransferase, uric acid, and insulin were significant after being adjusted for percentage overweight, percentage body fat, or sex.

DISCUSSION

Serum adiponectin level is decreased in obese children depending on the accumulation of visceral fat and is restored toward normal level by slimming.

Authors+Show Affiliations

Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Iseigaoka, Kitakyushu, Japan. kasayama@med.uoeh-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12972677

Citation

Asayama, Kohtaro, et al. "Decrease in Serum Adiponectin Level Due to Obesity and Visceral Fat Accumulation in Children." Obesity Research, vol. 11, no. 9, 2003, pp. 1072-9.
Asayama K, Hayashibe H, Dobashi K, et al. Decrease in serum adiponectin level due to obesity and visceral fat accumulation in children. Obes Res. 2003;11(9):1072-9.
Asayama, K., Hayashibe, H., Dobashi, K., Uchida, N., Nakane, T., Kodera, K., Shirahata, A., & Taniyama, M. (2003). Decrease in serum adiponectin level due to obesity and visceral fat accumulation in children. Obesity Research, 11(9), 1072-9.
Asayama K, et al. Decrease in Serum Adiponectin Level Due to Obesity and Visceral Fat Accumulation in Children. Obes Res. 2003;11(9):1072-9. PubMed PMID: 12972677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decrease in serum adiponectin level due to obesity and visceral fat accumulation in children. AU - Asayama,Kohtaro, AU - Hayashibe,Hidemasa, AU - Dobashi,Kazushige, AU - Uchida,Norihiko, AU - Nakane,Takaya, AU - Kodera,Kohji, AU - Shirahata,Akira, AU - Taniyama,Matsuo, PY - 2003/9/16/pubmed PY - 2004/2/6/medline PY - 2003/9/16/entrez SP - 1072 EP - 9 JF - Obesity research JO - Obes. Res. VL - 11 IS - 9 N2 - OBJECTIVE: To determine whether serum adiponectin is decreased in obesity and is restored toward normal level after treatment in children. RESEARCH METHODS AND PROCEDURES: Subjects were 53 Japanese obese children, 33 boys and 20 girls (6 to 14 years old), and 30 age-matched nonobese controls for measuring adiponectin (16 boys and 14 girls). Blood was drawn after an overnight fast, and the obese children were subjected to anthropometric measurements including waist and hip circumferences and skinfold thicknesses. Paired samples were obtained from 21 obese children who underwent psychoeducational therapy. Visceral adipose tissue area was measured by computed tomography. Adiponectin was assayed by an enzyme-linked immunosorbent assay. RESULTS: The serum levels of alanine aminotransferase, uric acid, triglyceride, total cholesterol, low-density lipoprotein-cholesterol, total cholesterol/high-density lipoprotein-cholesterol, apo B, apo B/apo A(1), and insulin in obese children were higher than the reference values. Serum adiponectin level was lower in the obese children than in the controls (6.4 +/- 0.6 vs. 10.2 +/- 0.8 mg/L, means +/- SEM, p < 0.001). In 21 obese children whose percent overweight declined during therapy, the adiponectin level increased (p = 0.002). The adiponectin level was correlated inversely with visceral adipose tissue area in obese children (r = -0.531, p < 0.001). The inverse correlations of adiponectin with alanine aminotransferase, uric acid, and insulin were significant after being adjusted for percentage overweight, percentage body fat, or sex. DISCUSSION: Serum adiponectin level is decreased in obese children depending on the accumulation of visceral fat and is restored toward normal level by slimming. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/12972677/Decrease_in_serum_adiponectin_level_due_to_obesity_and_visceral_fat_accumulation_in_children_ L2 - https://doi.org/10.1038/oby.2003.147 DB - PRIME DP - Unbound Medicine ER -