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Exercise and diastolic function after myocardial infarction.
Med Sci Sports Exerc. 2003 Sep; 35(9):1471-6.MS

Abstract

PURPOSE

The purpose of this study was to determine the effects of exercise training on LV geometry and LV diastolic function in a rat model of MI.

METHODS

One month after MI induced by ligation of the left anterior descending artery (N = 45) or sham operation (N = 26), rats were randomized to either a sedentary or exercise group. Exercise consisted of treadmill running at 24 m.min-1, 1 h.d-1, 5 d.wk-1, for 3 wk. Passive LV pressure volume relationships were established with an isolated, red-cell-perfused Langendorff preparation. Infarct size was determined histologically and categorized as small (<30% of LV) or large (> or =30% of LV).

RESULTS

LV end-diastolic pressure-volume relationships were shifted rightward with increasing infarct size (P < 0.05). Exercise training further shifted the LV end-diastolic pressure-volume relationships rightward in sham, small MI and large MI (P < 0.05). Peak LV developed pressure was comparable in sedentary and exercised-trained hearts in sham, small MI, and large MI. LV diameter and septal wall thickness were greatest in large MI (P < 0.05). Exercise-trained hearts showed a tendency for a greater LV diameter and septal wall thickness in sham, small MI, and large MI. Scar thinning was most notable in large MI (P < 0.05).

CONCLUSION

Moderate-intensity treadmill running induces myocardial remodeling and a rightward shift in the LV end-diastolic pressure-volume relationship after MI, an adaptation similar to what is observed with exercise training in sham hearts without MI.

Authors+Show Affiliations

Department of Kinesiology, Temple University, Philadelphia, PA 19003, USA. jlibonat@astro.temple.edu

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12972864

Citation

Libonati, Joseph R.. "Exercise and Diastolic Function After Myocardial Infarction." Medicine and Science in Sports and Exercise, vol. 35, no. 9, 2003, pp. 1471-6.
Libonati JR. Exercise and diastolic function after myocardial infarction. Med Sci Sports Exerc. 2003;35(9):1471-6.
Libonati, J. R. (2003). Exercise and diastolic function after myocardial infarction. Medicine and Science in Sports and Exercise, 35(9), 1471-6.
Libonati JR. Exercise and Diastolic Function After Myocardial Infarction. Med Sci Sports Exerc. 2003;35(9):1471-6. PubMed PMID: 12972864.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exercise and diastolic function after myocardial infarction. A1 - Libonati,Joseph R, PY - 2003/9/16/pubmed PY - 2004/1/7/medline PY - 2003/9/16/entrez SP - 1471 EP - 6 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 35 IS - 9 N2 - PURPOSE: The purpose of this study was to determine the effects of exercise training on LV geometry and LV diastolic function in a rat model of MI. METHODS: One month after MI induced by ligation of the left anterior descending artery (N = 45) or sham operation (N = 26), rats were randomized to either a sedentary or exercise group. Exercise consisted of treadmill running at 24 m.min-1, 1 h.d-1, 5 d.wk-1, for 3 wk. Passive LV pressure volume relationships were established with an isolated, red-cell-perfused Langendorff preparation. Infarct size was determined histologically and categorized as small (<30% of LV) or large (> or =30% of LV). RESULTS: LV end-diastolic pressure-volume relationships were shifted rightward with increasing infarct size (P < 0.05). Exercise training further shifted the LV end-diastolic pressure-volume relationships rightward in sham, small MI and large MI (P < 0.05). Peak LV developed pressure was comparable in sedentary and exercised-trained hearts in sham, small MI, and large MI. LV diameter and septal wall thickness were greatest in large MI (P < 0.05). Exercise-trained hearts showed a tendency for a greater LV diameter and septal wall thickness in sham, small MI, and large MI. Scar thinning was most notable in large MI (P < 0.05). CONCLUSION: Moderate-intensity treadmill running induces myocardial remodeling and a rightward shift in the LV end-diastolic pressure-volume relationship after MI, an adaptation similar to what is observed with exercise training in sham hearts without MI. SN - 0195-9131 UR - https://www.unboundmedicine.com/medline/citation/12972864/Exercise_and_diastolic_function_after_myocardial_infarction_ L2 - https://doi.org/10.1249/01.MSS.0000084420.77802.DA DB - PRIME DP - Unbound Medicine ER -