Tags

Type your tag names separated by a space and hit enter

Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.
Nat Neurosci 2003; 6(10):1100-7NN

Abstract

Corticotropin-releasing hormone (CRH) is centrally involved in coordinating responses to a variety of stress-associated stimuli. Recent clinical data implicate CRH in the pathophysiology of human affective disorders. To differentiate the CNS pathways involving CRH and CRH receptor 1 (Crhr1) that modulate behavior from those that regulate neuroendocrine function, we generated a conditional knockout mouse line (Crhr1(loxP/loxP)Camk2a-cre) in which Crhr1 function is inactivated postnatally in anterior forebrain and limbic brain structures, but not in the pituitary. This leaves the hypothalamic-pituitary-adrenocortical (HPA) system intact. Crhr1(loxP/loxP)Camk2a-cre mutants showed reduced anxiety, and the basal activity of their HPA system was normal. In contrast to Crhr1 null mutants, conditional mutants were hypersensitive to stress corticotropin and corticosterone levels remained significantly elevated after stress. Our data clearly show that limbic Crhr1 modulates anxiety-related behavior and that this effect is independent of HPA system function. Furthermore, we provide evidence for a new role of limbic Crhr1 in neuroendocrine adaptation to stress.

Authors+Show Affiliations

Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, Munich 80804, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12973355

Citation

Müller, Marianne B., et al. "Limbic Corticotropin-releasing Hormone Receptor 1 Mediates Anxiety-related Behavior and Hormonal Adaptation to Stress." Nature Neuroscience, vol. 6, no. 10, 2003, pp. 1100-7.
Müller MB, Zimmermann S, Sillaber I, et al. Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nat Neurosci. 2003;6(10):1100-7.
Müller, M. B., Zimmermann, S., Sillaber, I., Hagemeyer, T. P., Deussing, J. M., Timpl, P., ... Wurst, W. (2003). Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nature Neuroscience, 6(10), pp. 1100-7.
Müller MB, et al. Limbic Corticotropin-releasing Hormone Receptor 1 Mediates Anxiety-related Behavior and Hormonal Adaptation to Stress. Nat Neurosci. 2003;6(10):1100-7. PubMed PMID: 12973355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. AU - Müller,Marianne B, AU - Zimmermann,Stephan, AU - Sillaber,Inge, AU - Hagemeyer,Thomas P, AU - Deussing,Jan M, AU - Timpl,Peter, AU - Kormann,Michael S D, AU - Droste,Susanne K, AU - Kühn,Ralf, AU - Reul,Johannes M H M, AU - Holsboer,Florian, AU - Wurst,Wolfgang, Y1 - 2003/09/14/ PY - 2003/06/06/received PY - 2003/07/31/accepted PY - 2003/9/16/pubmed PY - 2003/12/6/medline PY - 2003/9/16/entrez SP - 1100 EP - 7 JF - Nature neuroscience JO - Nat. Neurosci. VL - 6 IS - 10 N2 - Corticotropin-releasing hormone (CRH) is centrally involved in coordinating responses to a variety of stress-associated stimuli. Recent clinical data implicate CRH in the pathophysiology of human affective disorders. To differentiate the CNS pathways involving CRH and CRH receptor 1 (Crhr1) that modulate behavior from those that regulate neuroendocrine function, we generated a conditional knockout mouse line (Crhr1(loxP/loxP)Camk2a-cre) in which Crhr1 function is inactivated postnatally in anterior forebrain and limbic brain structures, but not in the pituitary. This leaves the hypothalamic-pituitary-adrenocortical (HPA) system intact. Crhr1(loxP/loxP)Camk2a-cre mutants showed reduced anxiety, and the basal activity of their HPA system was normal. In contrast to Crhr1 null mutants, conditional mutants were hypersensitive to stress corticotropin and corticosterone levels remained significantly elevated after stress. Our data clearly show that limbic Crhr1 modulates anxiety-related behavior and that this effect is independent of HPA system function. Furthermore, we provide evidence for a new role of limbic Crhr1 in neuroendocrine adaptation to stress. SN - 1097-6256 UR - https://www.unboundmedicine.com/medline/citation/12973355/Limbic_corticotropin_releasing_hormone_receptor_1_mediates_anxiety_related_behavior_and_hormonal_adaptation_to_stress_ L2 - http://dx.doi.org/10.1038/nn1123 DB - PRIME DP - Unbound Medicine ER -