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Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to beta-amyloid peptide42.
Arch Neurol 2003; 60(9):1202-6AN

Abstract

BACKGROUND

The antemortem diagnosis of Alzheimer disease (AD) requires time-consuming and costly procedures. Therefore, biochemical tests that can direct the physician rapidly to the correct diagnosis are highly desirable. Measurement of single biochemical markers in cerebrospinal fluid (CSF), such as total tau protein and beta-amyloid peptide42 (Abeta42), shows robust alterations that highly correlate with the clinical diagnosis of AD but generally lack sufficient diagnostic accuracy.

OBJECTIVE

To study the combination of CSF phosphorylated tau protein (phospho-tau) and Abeta42 as biochemical markers for AD.

METHODS

We combined CSF measurements of phospho-tau and Abeta42 in 100 consecutive patients who under-went diagnostic workup for dementia and in 31 healthy control subjects.

RESULTS

We found that the calculated ratio of phospho-tau to Abeta42 was significantly increased in patients with AD and provided high diagnostic accuracy in distinguishing patients with AD from healthy control subjects (sensitivity, 86%; specificity, 97%), subjects with non-AD dementias (sensitivity, 80%; specificity, 73%), and subjects with other neurological disorders (sensitivity, 80%; specificity, 89%).

CONCLUSION

The diagnostic usefulness of the CSF ratio of phospho-tau to Abeta42 is superior to either measure alone and can be recommended as an aid to evaluating individuals suspected of having dementia.

Authors+Show Affiliations

Division of Psychiatry Research, University of Zurich, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12975284

Citation

Maddalena, Alessia, et al. "Biochemical Diagnosis of Alzheimer Disease By Measuring the Cerebrospinal Fluid Ratio of Phosphorylated Tau Protein to Beta-amyloid Peptide42." Archives of Neurology, vol. 60, no. 9, 2003, pp. 1202-6.
Maddalena A, Papassotiropoulos A, Müller-Tillmanns B, et al. Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to beta-amyloid peptide42. Arch Neurol. 2003;60(9):1202-6.
Maddalena, A., Papassotiropoulos, A., Müller-Tillmanns, B., Jung, H. H., Hegi, T., Nitsch, R. M., & Hock, C. (2003). Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to beta-amyloid peptide42. Archives of Neurology, 60(9), pp. 1202-6.
Maddalena A, et al. Biochemical Diagnosis of Alzheimer Disease By Measuring the Cerebrospinal Fluid Ratio of Phosphorylated Tau Protein to Beta-amyloid Peptide42. Arch Neurol. 2003;60(9):1202-6. PubMed PMID: 12975284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biochemical diagnosis of Alzheimer disease by measuring the cerebrospinal fluid ratio of phosphorylated tau protein to beta-amyloid peptide42. AU - Maddalena,Alessia, AU - Papassotiropoulos,Andreas, AU - Müller-Tillmanns,Britta, AU - Jung,Hans H, AU - Hegi,Thomas, AU - Nitsch,Roger M, AU - Hock,Christoph, PY - 2003/9/17/pubmed PY - 2003/10/24/medline PY - 2003/9/17/entrez SP - 1202 EP - 6 JF - Archives of neurology JO - Arch. Neurol. VL - 60 IS - 9 N2 - BACKGROUND: The antemortem diagnosis of Alzheimer disease (AD) requires time-consuming and costly procedures. Therefore, biochemical tests that can direct the physician rapidly to the correct diagnosis are highly desirable. Measurement of single biochemical markers in cerebrospinal fluid (CSF), such as total tau protein and beta-amyloid peptide42 (Abeta42), shows robust alterations that highly correlate with the clinical diagnosis of AD but generally lack sufficient diagnostic accuracy. OBJECTIVE: To study the combination of CSF phosphorylated tau protein (phospho-tau) and Abeta42 as biochemical markers for AD. METHODS: We combined CSF measurements of phospho-tau and Abeta42 in 100 consecutive patients who under-went diagnostic workup for dementia and in 31 healthy control subjects. RESULTS: We found that the calculated ratio of phospho-tau to Abeta42 was significantly increased in patients with AD and provided high diagnostic accuracy in distinguishing patients with AD from healthy control subjects (sensitivity, 86%; specificity, 97%), subjects with non-AD dementias (sensitivity, 80%; specificity, 73%), and subjects with other neurological disorders (sensitivity, 80%; specificity, 89%). CONCLUSION: The diagnostic usefulness of the CSF ratio of phospho-tau to Abeta42 is superior to either measure alone and can be recommended as an aid to evaluating individuals suspected of having dementia. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/12975284/Biochemical_diagnosis_of_Alzheimer_disease_by_measuring_the_cerebrospinal_fluid_ratio_of_phosphorylated_tau_protein_to_beta_amyloid_peptide42_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/vol/60/pg/1202 DB - PRIME DP - Unbound Medicine ER -