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Detection of undiagnosed coeliac disease with atypical features using antireticulin and antigliadin antibodies.
Q J Med 1992; 84(305):713-8QJ

Abstract

Eighteen patients with a variety of non-gastrointestinal symptoms were incidentally found to have circulating antireticulin antibody and on subsequent testing were also positive for antigliadin antibody. They prospectively underwent jejunal biopsy to determine whether or not they had coeliac disease. Their age range was 21-79 years (mean 42 years). Enteropathy was present in 13 (72 per cent) and was always associated with circulating IgA antigliadin antibody. Enteropathy was not present in the five cases who had only IgG antibody. Clinical improvement occurred in eight of 11 patients who complied with a gluten-free diet and was paralleled by an improvement in the mucosal histology in seven of eight who were re-biopsied. The most remarkable cases were two patients who presented with severe debility and no apparent haematological or biochemical abnormalities, and who subsequently made a dramatic recovery on a gluten-free diet. It is concluded that antireticulin antibody detected by routine autoantibody screening and confirmed to have IgA antigliadin antibody specificity is a useful indicator of an otherwise undiagnosed enteropathy. This serves to emphasize that the condition can sometimes be associated with atypical features and significant morbidity.

Authors+Show Affiliations

Department of Gastroenterology, Belfast City Hospital.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1303650

Citation

Watson, R G., et al. "Detection of Undiagnosed Coeliac Disease With Atypical Features Using Antireticulin and Antigliadin Antibodies." The Quarterly Journal of Medicine, vol. 84, no. 305, 1992, pp. 713-8.
Watson RG, McMillan SA, Dickey W, et al. Detection of undiagnosed coeliac disease with atypical features using antireticulin and antigliadin antibodies. Q J Med. 1992;84(305):713-8.
Watson, R. G., McMillan, S. A., Dickey, W., Biggart, J. D., & Porter, K. G. (1992). Detection of undiagnosed coeliac disease with atypical features using antireticulin and antigliadin antibodies. The Quarterly Journal of Medicine, 84(305), pp. 713-8.
Watson RG, et al. Detection of Undiagnosed Coeliac Disease With Atypical Features Using Antireticulin and Antigliadin Antibodies. Q J Med. 1992;84(305):713-8. PubMed PMID: 1303650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of undiagnosed coeliac disease with atypical features using antireticulin and antigliadin antibodies. AU - Watson,R G, AU - McMillan,S A, AU - Dickey,W, AU - Biggart,J D, AU - Porter,K G, PY - 1992/9/1/pubmed PY - 1992/9/1/medline PY - 1992/9/1/entrez SP - 713 EP - 8 JF - The Quarterly journal of medicine JO - Q. J. Med. VL - 84 IS - 305 N2 - Eighteen patients with a variety of non-gastrointestinal symptoms were incidentally found to have circulating antireticulin antibody and on subsequent testing were also positive for antigliadin antibody. They prospectively underwent jejunal biopsy to determine whether or not they had coeliac disease. Their age range was 21-79 years (mean 42 years). Enteropathy was present in 13 (72 per cent) and was always associated with circulating IgA antigliadin antibody. Enteropathy was not present in the five cases who had only IgG antibody. Clinical improvement occurred in eight of 11 patients who complied with a gluten-free diet and was paralleled by an improvement in the mucosal histology in seven of eight who were re-biopsied. The most remarkable cases were two patients who presented with severe debility and no apparent haematological or biochemical abnormalities, and who subsequently made a dramatic recovery on a gluten-free diet. It is concluded that antireticulin antibody detected by routine autoantibody screening and confirmed to have IgA antigliadin antibody specificity is a useful indicator of an otherwise undiagnosed enteropathy. This serves to emphasize that the condition can sometimes be associated with atypical features and significant morbidity. SN - 0033-5622 UR - https://www.unboundmedicine.com/medline/citation/1303650/Detection_of_undiagnosed_coeliac_disease_with_atypical_features_using_antireticulin_and_antigliadin_antibodies_ L2 - https://medlineplus.gov/celiacdisease.html DB - PRIME DP - Unbound Medicine ER -