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[Investigation of factors determining stability of BCG vaccine].
Med Dosw Mikrobiol 1992; 44(3-4):137-44MD

Abstract

This study was aimed at establishment of influence of a carrier-sodium glutamate and of changes introduced during the process of freeze-drying on survival of BCG bacilli during lyophilization, as well on thermostability and homogeneity of the vaccine and its immunogenicity. It was found that appropriate drying of the vaccine after freeze-drying performed in higher temperature influences favorably its thermostability. Concentration of the carrier is significantly influential for survival of bacilli during freeze-drying. Vaccine containing 1% of sodium glutamate was characterized by best thermostability, homogeneity and high survival of bacilli during freeze-drying. These parameters were keeping on a high level also one year after expiration date. It was shown that there exists a proportional dependence between immunogenicity of the vaccine measured indirectly by intensiveness of tuberculin allergization and number of live particles of BCG contained in vaccination dose.

Authors+Show Affiliations

Zakład Badania Surowic i Szczepionek PZH w Warszawie.

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

1305917

Citation

Janaszek, W. "[Investigation of Factors Determining Stability of BCG Vaccine]." Medycyna Doswiadczalna I Mikrobiologia, vol. 44, no. 3-4, 1992, pp. 137-44.
Janaszek W. [Investigation of factors determining stability of BCG vaccine]. Med Dosw Mikrobiol. 1992;44(3-4):137-44.
Janaszek, W. (1992). [Investigation of factors determining stability of BCG vaccine]. Medycyna Doswiadczalna I Mikrobiologia, 44(3-4), pp. 137-44.
Janaszek W. [Investigation of Factors Determining Stability of BCG Vaccine]. Med Dosw Mikrobiol. 1992;44(3-4):137-44. PubMed PMID: 1305917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Investigation of factors determining stability of BCG vaccine]. A1 - Janaszek,W, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 137 EP - 44 JF - Medycyna doswiadczalna i mikrobiologia JO - Med Dosw Mikrobiol VL - 44 IS - 3-4 N2 - This study was aimed at establishment of influence of a carrier-sodium glutamate and of changes introduced during the process of freeze-drying on survival of BCG bacilli during lyophilization, as well on thermostability and homogeneity of the vaccine and its immunogenicity. It was found that appropriate drying of the vaccine after freeze-drying performed in higher temperature influences favorably its thermostability. Concentration of the carrier is significantly influential for survival of bacilli during freeze-drying. Vaccine containing 1% of sodium glutamate was characterized by best thermostability, homogeneity and high survival of bacilli during freeze-drying. These parameters were keeping on a high level also one year after expiration date. It was shown that there exists a proportional dependence between immunogenicity of the vaccine measured indirectly by intensiveness of tuberculin allergization and number of live particles of BCG contained in vaccination dose. SN - 0025-8601 UR - https://www.unboundmedicine.com/medline/citation/1305917/[Investigation_of_factors_determining_stability_of_BCG_vaccine]_ DB - PRIME DP - Unbound Medicine ER -