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Effects of tartrate thyrotropin-releasing hormone treatment on serum thyrotropin, free triiodothyronine, free thyroxine and prolactin levels in patients with spinocerebellar degeneration.
Horm Res. 1992; 38(3-4):160-3.HR

Abstract

The aim of the present study was to investigate the pituitary-thyroid axis function during the long-term (30 days) intramuscular administration of 4 mg/day of thyrotropin-releasing hormone tartrate (TRH-T) in 15 patients with spinocerebellar degeneration. The study was performed as follows: (1) acute 4 mg TRH-T test with hourly prolactin (PRL) and thyroid-stimulating hormone (TSH) level evaluations for 6 h; (2) placebo; and (3) 4 mg/day of TRH-T administration for 30 days with TSH, PRL, and free T3 and T4 (FT3 and FT4) levels evaluated on days 1, 15 and 30. Hormone determination was performed just before and 1 h after placebo or TRH-T administration. The acute administration of TRH-T caused a sustained rise of TSH which lasted until the 6th hour and of PRL which declined after 1 h (p < 0.01). During placebo administration, no change of TSH, PRL, FT3 or FT4 was observed. On the 1st day of treatment, 1 h after the TRH-T injection, a significant increase of both TSH and PRL levels occurred (p < 0.01). As compared to the 1st day, a significant decrease of the TSH (p < 0.01) levels occurred on the 15th and 30th days before TRH-T: the TSH response to TRH-T administration was present although less than on the 1st day (p < 0.01). Moreover, throughout the whole period of treatment, no difference was recorded for PRL levels before or after TRH-T administration.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Chair of Endocrinology, 2nd School of Medicine, University of Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1306848

Citation

Merola, B, et al. "Effects of Tartrate Thyrotropin-releasing Hormone Treatment On Serum Thyrotropin, Free Triiodothyronine, Free Thyroxine and Prolactin Levels in Patients With Spinocerebellar Degeneration." Hormone Research, vol. 38, no. 3-4, 1992, pp. 160-3.
Merola B, Colao A, Di Renzo G, et al. Effects of tartrate thyrotropin-releasing hormone treatment on serum thyrotropin, free triiodothyronine, free thyroxine and prolactin levels in patients with spinocerebellar degeneration. Horm Res. 1992;38(3-4):160-3.
Merola, B., Colao, A., Di Renzo, G., Filla, A., Campanella, G., & Lombardi, G. (1992). Effects of tartrate thyrotropin-releasing hormone treatment on serum thyrotropin, free triiodothyronine, free thyroxine and prolactin levels in patients with spinocerebellar degeneration. Hormone Research, 38(3-4), 160-3.
Merola B, et al. Effects of Tartrate Thyrotropin-releasing Hormone Treatment On Serum Thyrotropin, Free Triiodothyronine, Free Thyroxine and Prolactin Levels in Patients With Spinocerebellar Degeneration. Horm Res. 1992;38(3-4):160-3. PubMed PMID: 1306848.
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TY - JOUR T1 - Effects of tartrate thyrotropin-releasing hormone treatment on serum thyrotropin, free triiodothyronine, free thyroxine and prolactin levels in patients with spinocerebellar degeneration. AU - Merola,B, AU - Colao,A, AU - Di Renzo,G, AU - Filla,A, AU - Campanella,G, AU - Lombardi,G, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 160 EP - 3 JF - Hormone research JO - Horm Res VL - 38 IS - 3-4 N2 - The aim of the present study was to investigate the pituitary-thyroid axis function during the long-term (30 days) intramuscular administration of 4 mg/day of thyrotropin-releasing hormone tartrate (TRH-T) in 15 patients with spinocerebellar degeneration. The study was performed as follows: (1) acute 4 mg TRH-T test with hourly prolactin (PRL) and thyroid-stimulating hormone (TSH) level evaluations for 6 h; (2) placebo; and (3) 4 mg/day of TRH-T administration for 30 days with TSH, PRL, and free T3 and T4 (FT3 and FT4) levels evaluated on days 1, 15 and 30. Hormone determination was performed just before and 1 h after placebo or TRH-T administration. The acute administration of TRH-T caused a sustained rise of TSH which lasted until the 6th hour and of PRL which declined after 1 h (p < 0.01). During placebo administration, no change of TSH, PRL, FT3 or FT4 was observed. On the 1st day of treatment, 1 h after the TRH-T injection, a significant increase of both TSH and PRL levels occurred (p < 0.01). As compared to the 1st day, a significant decrease of the TSH (p < 0.01) levels occurred on the 15th and 30th days before TRH-T: the TSH response to TRH-T administration was present although less than on the 1st day (p < 0.01). Moreover, throughout the whole period of treatment, no difference was recorded for PRL levels before or after TRH-T administration.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0301-0163 UR - https://www.unboundmedicine.com/medline/citation/1306848/Effects_of_tartrate_thyrotropin_releasing_hormone_treatment_on_serum_thyrotropin_free_triiodothyronine_free_thyroxine_and_prolactin_levels_in_patients_with_spinocerebellar_degeneration_ L2 - https://www.karger.com?DOI=10.1159/000182533 DB - PRIME DP - Unbound Medicine ER -