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Effects of tartrate thyrotropin-releasing hormone treatment on serum thyrotropin, free triiodothyronine, free thyroxine and prolactin levels in patients with spinocerebellar degeneration.
Horm Res. 1992; 38(3-4):160-3.HR

Abstract

The aim of the present study was to investigate the pituitary-thyroid axis function during the long-term (30 days) intramuscular administration of 4 mg/day of thyrotropin-releasing hormone tartrate (TRH-T) in 15 patients with spinocerebellar degeneration. The study was performed as follows: (1) acute 4 mg TRH-T test with hourly prolactin (PRL) and thyroid-stimulating hormone (TSH) level evaluations for 6 h; (2) placebo; and (3) 4 mg/day of TRH-T administration for 30 days with TSH, PRL, and free T3 and T4 (FT3 and FT4) levels evaluated on days 1, 15 and 30. Hormone determination was performed just before and 1 h after placebo or TRH-T administration. The acute administration of TRH-T caused a sustained rise of TSH which lasted until the 6th hour and of PRL which declined after 1 h (p < 0.01). During placebo administration, no change of TSH, PRL, FT3 or FT4 was observed. On the 1st day of treatment, 1 h after the TRH-T injection, a significant increase of both TSH and PRL levels occurred (p < 0.01). As compared to the 1st day, a significant decrease of the TSH (p < 0.01) levels occurred on the 15th and 30th days before TRH-T: the TSH response to TRH-T administration was present although less than on the 1st day (p < 0.01). Moreover, throughout the whole period of treatment, no difference was recorded for PRL levels before or after TRH-T administration.(ABSTRACT TRUNCATED AT 250 WORDS)

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Authors+Show Affiliations

Merola B
Chair of Endocrinology, 2nd School of Medicine, University of Naples, Italy.
Colao A
No affiliation info available
Di Renzo G
No affiliation info available
Filla A
No affiliation info available
Campanella G
No affiliation info available
Lombardi G
No affiliation info available

MeSH

AdolescentAdultHumansKineticsMaleProlactinSpinocerebellar DegenerationsThyrotropinThyrotropin-Releasing HormoneThyroxineTriiodothyronine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1306848

Citation

Merola, B, et al. "Effects of Tartrate Thyrotropin-releasing Hormone Treatment On Serum Thyrotropin, Free Triiodothyronine, Free Thyroxine and Prolactin Levels in Patients With Spinocerebellar Degeneration." Hormone Research, vol. 38, no. 3-4, 1992, pp. 160-3.
Merola B, Colao A, Di Renzo G, et al. Effects of tartrate thyrotropin-releasing hormone treatment on serum thyrotropin, free triiodothyronine, free thyroxine and prolactin levels in patients with spinocerebellar degeneration. Horm Res. 1992;38(3-4):160-3.
Merola, B., Colao, A., Di Renzo, G., Filla, A., Campanella, G., & Lombardi, G. (1992). Effects of tartrate thyrotropin-releasing hormone treatment on serum thyrotropin, free triiodothyronine, free thyroxine and prolactin levels in patients with spinocerebellar degeneration. Hormone Research, 38(3-4), 160-3.
Merola B, et al. Effects of Tartrate Thyrotropin-releasing Hormone Treatment On Serum Thyrotropin, Free Triiodothyronine, Free Thyroxine and Prolactin Levels in Patients With Spinocerebellar Degeneration. Horm Res. 1992;38(3-4):160-3. PubMed PMID: 1306848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of tartrate thyrotropin-releasing hormone treatment on serum thyrotropin, free triiodothyronine, free thyroxine and prolactin levels in patients with spinocerebellar degeneration. AU - Merola,B, AU - Colao,A, AU - Di Renzo,G, AU - Filla,A, AU - Campanella,G, AU - Lombardi,G, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 160 EP - 3 JF - Hormone research JO - Horm Res VL - 38 IS - 3-4 N2 - The aim of the present study was to investigate the pituitary-thyroid axis function during the long-term (30 days) intramuscular administration of 4 mg/day of thyrotropin-releasing hormone tartrate (TRH-T) in 15 patients with spinocerebellar degeneration. The study was performed as follows: (1) acute 4 mg TRH-T test with hourly prolactin (PRL) and thyroid-stimulating hormone (TSH) level evaluations for 6 h; (2) placebo; and (3) 4 mg/day of TRH-T administration for 30 days with TSH, PRL, and free T3 and T4 (FT3 and FT4) levels evaluated on days 1, 15 and 30. Hormone determination was performed just before and 1 h after placebo or TRH-T administration. The acute administration of TRH-T caused a sustained rise of TSH which lasted until the 6th hour and of PRL which declined after 1 h (p < 0.01). During placebo administration, no change of TSH, PRL, FT3 or FT4 was observed. On the 1st day of treatment, 1 h after the TRH-T injection, a significant increase of both TSH and PRL levels occurred (p < 0.01). As compared to the 1st day, a significant decrease of the TSH (p < 0.01) levels occurred on the 15th and 30th days before TRH-T: the TSH response to TRH-T administration was present although less than on the 1st day (p < 0.01). Moreover, throughout the whole period of treatment, no difference was recorded for PRL levels before or after TRH-T administration.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0301-0163 UR - https://www.unboundmedicine.com/medline/citation/1306848/Effects_of_tartrate_thyrotropin_releasing_hormone_treatment_on_serum_thyrotropin_free_triiodothyronine_free_thyroxine_and_prolactin_levels_in_patients_with_spinocerebellar_degeneration_ L2 - https://www.karger.com?DOI=10.1159/000182533 DB - PRIME DP - Unbound Medicine ER -

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