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Alpha-hydroxybutyrate dehydrogenase and the diagnosis of painful crisis in sickle cell anaemia.
Afr J Med Med Sci. 1992 Dec; 21(2):13-7.AJ

Abstract

To assess the value of alpha-hydroxybutyrate dehydrogenase (alpha-HBDH) in the diagnosis of painful crisis (PC) of sickle cell anaemia (SCA), we studied plasma enzyme levels in 55 children with HbSS and 21 control subjects with haemoglobin genotype AA. In 21 children with SCA, mean plasma alpha-HBDH was 373.8 +/- 113.5 micrograms/l during PC and during steady state in 34 children, it was 341.2 +/- 103.4 micrograms/l. These values were significantly higher than that of 128 +/- 19.5 micrograms/l obtained in control subjects. However, the difference between mean plasma alpha-HBDH levels in SCA children in PC and in steady state was 32.6 micrograms/l, t = 1.095; P < 0.2. There was no correlation between alpha-HBDH levels and reticulocyte counts (r = 0.0856; t = 0.4565; 0.7 < P < 0.6). The high levels of alpha-HBDH in patients with SCA is probably due to chronic haemolysis and not marrow infarction. Therefore, alpha-HBDH is of doubtful value in the diagnosis of painful crisis.

Authors+Show Affiliations

Institute of Child Health College of Medical Sciences, University of Benin.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1308075

Citation

Akenzua, G I., et al. "Alpha-hydroxybutyrate Dehydrogenase and the Diagnosis of Painful Crisis in Sickle Cell Anaemia." African Journal of Medicine and Medical Sciences, vol. 21, no. 2, 1992, pp. 13-7.
Akenzua GI, Ihongbe JC, Asemota HN. Alpha-hydroxybutyrate dehydrogenase and the diagnosis of painful crisis in sickle cell anaemia. Afr J Med Med Sci. 1992;21(2):13-7.
Akenzua, G. I., Ihongbe, J. C., & Asemota, H. N. (1992). Alpha-hydroxybutyrate dehydrogenase and the diagnosis of painful crisis in sickle cell anaemia. African Journal of Medicine and Medical Sciences, 21(2), 13-7.
Akenzua GI, Ihongbe JC, Asemota HN. Alpha-hydroxybutyrate Dehydrogenase and the Diagnosis of Painful Crisis in Sickle Cell Anaemia. Afr J Med Med Sci. 1992;21(2):13-7. PubMed PMID: 1308075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alpha-hydroxybutyrate dehydrogenase and the diagnosis of painful crisis in sickle cell anaemia. AU - Akenzua,G I, AU - Ihongbe,J C, AU - Asemota,H N, PY - 1992/12/1/pubmed PY - 1992/12/1/medline PY - 1992/12/1/entrez SP - 13 EP - 7 JF - African journal of medicine and medical sciences JO - Afr J Med Med Sci VL - 21 IS - 2 N2 - To assess the value of alpha-hydroxybutyrate dehydrogenase (alpha-HBDH) in the diagnosis of painful crisis (PC) of sickle cell anaemia (SCA), we studied plasma enzyme levels in 55 children with HbSS and 21 control subjects with haemoglobin genotype AA. In 21 children with SCA, mean plasma alpha-HBDH was 373.8 +/- 113.5 micrograms/l during PC and during steady state in 34 children, it was 341.2 +/- 103.4 micrograms/l. These values were significantly higher than that of 128 +/- 19.5 micrograms/l obtained in control subjects. However, the difference between mean plasma alpha-HBDH levels in SCA children in PC and in steady state was 32.6 micrograms/l, t = 1.095; P < 0.2. There was no correlation between alpha-HBDH levels and reticulocyte counts (r = 0.0856; t = 0.4565; 0.7 < P < 0.6). The high levels of alpha-HBDH in patients with SCA is probably due to chronic haemolysis and not marrow infarction. Therefore, alpha-HBDH is of doubtful value in the diagnosis of painful crisis. SN - 0309-3913 UR - https://www.unboundmedicine.com/medline/citation/1308075/Alpha_hydroxybutyrate_dehydrogenase_and_the_diagnosis_of_painful_crisis_in_sickle_cell_anaemia_ L2 - https://medlineplus.gov/pain.html DB - PRIME DP - Unbound Medicine ER -