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Comparison of two multidrug regimens in multibacillary leprosy.
Indian J Lepr. 1992 Oct-Dec; 64(4):501-4.IJ

Abstract

One of the technical problems relating to the multidrug therapy of leprosy is the slow decrease in the bacteriological index (BI) in multibacillary patients. In this study we have compared a regimen containing rifampicin given daily for 9 months with the standard WHO multidrug regimen for multibacillary leprosy. We have found, at the end of two years, a significantly greater fall of BI in patients who had received the regimen containing daily rifampicin as compared to those who had received pulsed doses of rifampicin. The doses of dapsone and clofazimine were similar in these two groups. It appears that daily administration of rifampicin may be useful in treating multibacillary patients in whom reduction in the BI is slower than expected. However, in view of its high cost and the very much increased incidence of type-2 lepra reactions and hepatitis, daily rifampicin therapy cannot be recommended for a control programme.

Authors+Show Affiliations

Dr Bandorawalla Leprosy Hospital, Kondhawa, Pune.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1308526

Citation

Jadhav, V H., et al. "Comparison of Two Multidrug Regimens in Multibacillary Leprosy." Indian Journal of Leprosy, vol. 64, no. 4, 1992, pp. 501-4.
Jadhav VH, Patki AH, Mehta JM. Comparison of two multidrug regimens in multibacillary leprosy. Indian J Lepr. 1992;64(4):501-4.
Jadhav, V. H., Patki, A. H., & Mehta, J. M. (1992). Comparison of two multidrug regimens in multibacillary leprosy. Indian Journal of Leprosy, 64(4), 501-4.
Jadhav VH, Patki AH, Mehta JM. Comparison of Two Multidrug Regimens in Multibacillary Leprosy. Indian J Lepr. 1992 Oct-Dec;64(4):501-4. PubMed PMID: 1308526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of two multidrug regimens in multibacillary leprosy. AU - Jadhav,V H, AU - Patki,A H, AU - Mehta,J M, PY - 1992/10/1/pubmed PY - 1992/10/1/medline PY - 1992/10/1/entrez SP - 501 EP - 4 JF - Indian journal of leprosy JO - Indian J Lepr VL - 64 IS - 4 N2 - One of the technical problems relating to the multidrug therapy of leprosy is the slow decrease in the bacteriological index (BI) in multibacillary patients. In this study we have compared a regimen containing rifampicin given daily for 9 months with the standard WHO multidrug regimen for multibacillary leprosy. We have found, at the end of two years, a significantly greater fall of BI in patients who had received the regimen containing daily rifampicin as compared to those who had received pulsed doses of rifampicin. The doses of dapsone and clofazimine were similar in these two groups. It appears that daily administration of rifampicin may be useful in treating multibacillary patients in whom reduction in the BI is slower than expected. However, in view of its high cost and the very much increased incidence of type-2 lepra reactions and hepatitis, daily rifampicin therapy cannot be recommended for a control programme. SN - 0254-9395 UR - https://www.unboundmedicine.com/medline/citation/1308526/Comparison_of_two_multidrug_regimens_in_multibacillary_leprosy_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -