Tags

Type your tag names separated by a space and hit enter

IgM antibody response in acute hepatitis C viral infection.
Blood 1992; 79(1):169-72Blood

Abstract

IgM antibody against hepatitis C virus (IgM anti-HCV) was measured in serial samples from 15 transfusion recipients in whom posttransfusion chronic non-A, non-B hepatitis (NANBH) developed and three plasmapheresis donors during acute HCV infection using recombinant proteins derived from three immunodominant regions: core, NS-3, and NS-4 (c100). IgM anti-HCV core was detected in 13 of 15 posttransfusion patients. Nine of these patients had transient, acute-phase IgM anti-HCV core detected coincidentally or earlier than active IgG anti-HCV core response. The average duration of IgM anti-HCV core reactivity was 8.1 +/- 3.7 weeks. One patient lacking an IgM anti-HCV core response had detectable IgM anti-HCV NS-3 during the acute phase. Passive transfer of IgM anti-HCV was not observed in these posttransfusion cases, in contrast to the high frequency observed for IgG anti-HCV. Late IgM anti-HCV was detectable against core, c100, and NS-3 in three, two, and one posttransfusion patients, respectively. These data indicate that IgM anti-HCV core is a useful acute-phase marker in HCV infection.

Authors+Show Affiliations

Abbott Laboratories, Abbott Park, IL 60064.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1309424

Citation

Clemens, J M., et al. "IgM Antibody Response in Acute Hepatitis C Viral Infection." Blood, vol. 79, no. 1, 1992, pp. 169-72.
Clemens JM, Taskar S, Chau K, et al. IgM antibody response in acute hepatitis C viral infection. Blood. 1992;79(1):169-72.
Clemens, J. M., Taskar, S., Chau, K., Vallari, D., Shih, J. W., Alter, H. J., ... Mimms, L. T. (1992). IgM antibody response in acute hepatitis C viral infection. Blood, 79(1), pp. 169-72.
Clemens JM, et al. IgM Antibody Response in Acute Hepatitis C Viral Infection. Blood. 1992 Jan 1;79(1):169-72. PubMed PMID: 1309424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - IgM antibody response in acute hepatitis C viral infection. AU - Clemens,J M, AU - Taskar,S, AU - Chau,K, AU - Vallari,D, AU - Shih,J W, AU - Alter,H J, AU - Schleicher,J B, AU - Mimms,L T, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 169 EP - 72 JF - Blood JO - Blood VL - 79 IS - 1 N2 - IgM antibody against hepatitis C virus (IgM anti-HCV) was measured in serial samples from 15 transfusion recipients in whom posttransfusion chronic non-A, non-B hepatitis (NANBH) developed and three plasmapheresis donors during acute HCV infection using recombinant proteins derived from three immunodominant regions: core, NS-3, and NS-4 (c100). IgM anti-HCV core was detected in 13 of 15 posttransfusion patients. Nine of these patients had transient, acute-phase IgM anti-HCV core detected coincidentally or earlier than active IgG anti-HCV core response. The average duration of IgM anti-HCV core reactivity was 8.1 +/- 3.7 weeks. One patient lacking an IgM anti-HCV core response had detectable IgM anti-HCV NS-3 during the acute phase. Passive transfer of IgM anti-HCV was not observed in these posttransfusion cases, in contrast to the high frequency observed for IgG anti-HCV. Late IgM anti-HCV was detectable against core, c100, and NS-3 in three, two, and one posttransfusion patients, respectively. These data indicate that IgM anti-HCV core is a useful acute-phase marker in HCV infection. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/1309424/IgM_antibody_response_in_acute_hepatitis_C_viral_infection_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -