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In vitro and in vivo inhibition of rat liver aldehyde dehydrogenase by S-methyl N,N-diethylthiolcarbamate sulfoxide, a new metabolite of disulfiram.
Biochem Pharmacol. 1992 Feb 04; 43(3):403-6.BP

Abstract

In summary, these data provide the first evidence that DETC-MeSO is a natural metabolite of disulfiram, and a potent inhibitor of rat liver mitochondrial low Km ALDH both in vitro and in vivo. It is therefore proposed that, based upon evidence to date, DETC-MeSO appears to be the chemical species to which disulfiram must be bioactivated, and is the metabolite most likely responsible for disulfiram's inhibition of rat liver mitochondrial low Km ALDH in vivo. Characterization of the properties of DETC-MeSO as the metabolite responsible for disulfiram's action as an ALDH inhibitor is presently in the process of being completed.

Authors+Show Affiliations

Hart BW
Department of Pharmacology and Toxicology, University of Kansas, Lawrence 66045.
Faiman MD
No affiliation info available

MeSH

Aldehyde DehydrogenaseAnimalsDisulfiramDitiocarbDose-Response Relationship, DrugMitochondria, LiverRats

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1311578

Citation

Hart, B W., and M D. Faiman. "In Vitro and in Vivo Inhibition of Rat Liver Aldehyde Dehydrogenase By S-methyl N,N-diethylthiolcarbamate Sulfoxide, a New Metabolite of Disulfiram." Biochemical Pharmacology, vol. 43, no. 3, 1992, pp. 403-6.
Hart BW, Faiman MD. In vitro and in vivo inhibition of rat liver aldehyde dehydrogenase by S-methyl N,N-diethylthiolcarbamate sulfoxide, a new metabolite of disulfiram. Biochem Pharmacol. 1992;43(3):403-6.
Hart, B. W., & Faiman, M. D. (1992). In vitro and in vivo inhibition of rat liver aldehyde dehydrogenase by S-methyl N,N-diethylthiolcarbamate sulfoxide, a new metabolite of disulfiram. Biochemical Pharmacology, 43(3), 403-6.
Hart BW, Faiman MD. In Vitro and in Vivo Inhibition of Rat Liver Aldehyde Dehydrogenase By S-methyl N,N-diethylthiolcarbamate Sulfoxide, a New Metabolite of Disulfiram. Biochem Pharmacol. 1992 Feb 4;43(3):403-6. PubMed PMID: 1311578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro and in vivo inhibition of rat liver aldehyde dehydrogenase by S-methyl N,N-diethylthiolcarbamate sulfoxide, a new metabolite of disulfiram. AU - Hart,B W, AU - Faiman,M D, PY - 1992/2/4/pubmed PY - 1992/2/4/medline PY - 1992/2/4/entrez SP - 403 EP - 6 JF - Biochemical pharmacology JO - Biochem Pharmacol VL - 43 IS - 3 N2 - In summary, these data provide the first evidence that DETC-MeSO is a natural metabolite of disulfiram, and a potent inhibitor of rat liver mitochondrial low Km ALDH both in vitro and in vivo. It is therefore proposed that, based upon evidence to date, DETC-MeSO appears to be the chemical species to which disulfiram must be bioactivated, and is the metabolite most likely responsible for disulfiram's inhibition of rat liver mitochondrial low Km ALDH in vivo. Characterization of the properties of DETC-MeSO as the metabolite responsible for disulfiram's action as an ALDH inhibitor is presently in the process of being completed. SN - 0006-2952 UR - https://www.unboundmedicine.com/medline/citation/1311578/In_vitro_and_in_vivo_inhibition_of_rat_liver_aldehyde_dehydrogenase_by_S_methyl_NN_diethylthiolcarbamate_sulfoxide_a_new_metabolite_of_disulfiram_ DB - PRIME DP - Unbound Medicine ER -