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Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects.
Br J Nutr 2003; 90(3):597-606BJ

Abstract

The aim of the present study was to compare the response of a range of atherogenic and thrombogenic risk markers to two dietary levels of saturated fatty acid (SFA) substitution with monounsaturated fatty acids (MUFA) in students living in a university hall of residence. Although the benefits of such diets have been reported for plasma lipoproteins in high-risk groups, more needs to be known about effects of more modest SFA-MUFA substitutions over the long term and in young healthy adults. In a parallel design over 16 weeks, fifty-one healthy young subjects were randomised to one of two diets: (1) a moderate-MUFA diet in which 16 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 25); (2) a high-MUFA diet in which 33 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 26). All subjects followed an 8-week run-in diet (reference diet), with a fatty acid composition close to the UK average values. There were no differences in plasma lipid responses between the two diets over 16 weeks of the study with similar reductions in total cholesterol (P<0.001) and LDL-cholesterol (P<0.01) in both groups; a small but significant reduction in HDL-cholesterol was also observed in both groups (P<0.01). Platelet responses to ADP (P<0.01) and arachidonic acid (P<0.05) differed with time on the two diets; at 16 weeks, platelet aggregatory response to ADP was significantly lower on the high-MUFA than the moderate-MUFA (P<0.01) diet; ADP responses were also significantly lower within this group at 8 (P<0.05) and 16 (P<0.01) weeks compared with baseline. There were no differences in fasting factor VII activity (factors VIIc and VIIag), fibrinogen concentration or tissue-type plasminogen activator activity between the diets. There were no differences in postprandial factor VIIc responses to a standard meal (area under the curve) between the diets after 16 weeks, but postprandial factor VIIc response was lower than on the high-MUFA diet compared with baseline (P<0.01). In conclusion, a high-MUFA diet sustains potentially beneficial effects on platelet aggregation and postprandial activation of factor VII. Moderate or high substitution of MUFA for SFA achieves similar reductions in fasting blood lipids in young healthy subjects.

Authors+Show Affiliations

School of Food Biosciences, University of Reading, Reading RG6 6AP, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

13129466

Citation

Smith, Ruth D., et al. "Long-term Monounsaturated Fatty Acid Diets Reduce Platelet Aggregation in Healthy Young Subjects." The British Journal of Nutrition, vol. 90, no. 3, 2003, pp. 597-606.
Smith RD, Kelly CN, Fielding BA, et al. Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects. Br J Nutr. 2003;90(3):597-606.
Smith, R. D., Kelly, C. N., Fielding, B. A., Hauton, D., Silva, K. D., Nydahl, M. C., ... Williams, C. M. (2003). Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects. The British Journal of Nutrition, 90(3), pp. 597-606.
Smith RD, et al. Long-term Monounsaturated Fatty Acid Diets Reduce Platelet Aggregation in Healthy Young Subjects. Br J Nutr. 2003;90(3):597-606. PubMed PMID: 13129466.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects. AU - Smith,Ruth D, AU - Kelly,Colette N M, AU - Fielding,Barbara A, AU - Hauton,David, AU - Silva,K D Renuka R, AU - Nydahl,Margaretha C, AU - Miller,George J, AU - Williams,Christine M, PY - 2003/9/18/pubmed PY - 2003/10/17/medline PY - 2003/9/18/entrez SP - 597 EP - 606 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 90 IS - 3 N2 - The aim of the present study was to compare the response of a range of atherogenic and thrombogenic risk markers to two dietary levels of saturated fatty acid (SFA) substitution with monounsaturated fatty acids (MUFA) in students living in a university hall of residence. Although the benefits of such diets have been reported for plasma lipoproteins in high-risk groups, more needs to be known about effects of more modest SFA-MUFA substitutions over the long term and in young healthy adults. In a parallel design over 16 weeks, fifty-one healthy young subjects were randomised to one of two diets: (1) a moderate-MUFA diet in which 16 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 25); (2) a high-MUFA diet in which 33 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 26). All subjects followed an 8-week run-in diet (reference diet), with a fatty acid composition close to the UK average values. There were no differences in plasma lipid responses between the two diets over 16 weeks of the study with similar reductions in total cholesterol (P<0.001) and LDL-cholesterol (P<0.01) in both groups; a small but significant reduction in HDL-cholesterol was also observed in both groups (P<0.01). Platelet responses to ADP (P<0.01) and arachidonic acid (P<0.05) differed with time on the two diets; at 16 weeks, platelet aggregatory response to ADP was significantly lower on the high-MUFA than the moderate-MUFA (P<0.01) diet; ADP responses were also significantly lower within this group at 8 (P<0.05) and 16 (P<0.01) weeks compared with baseline. There were no differences in fasting factor VII activity (factors VIIc and VIIag), fibrinogen concentration or tissue-type plasminogen activator activity between the diets. There were no differences in postprandial factor VIIc responses to a standard meal (area under the curve) between the diets after 16 weeks, but postprandial factor VIIc response was lower than on the high-MUFA diet compared with baseline (P<0.01). In conclusion, a high-MUFA diet sustains potentially beneficial effects on platelet aggregation and postprandial activation of factor VII. Moderate or high substitution of MUFA for SFA achieves similar reductions in fasting blood lipids in young healthy subjects. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/13129466/Long_term_monounsaturated_fatty_acid_diets_reduce_platelet_aggregation_in_healthy_young_subjects_ L2 - https://www.cambridge.org/core/product/identifier/S000711450300165X/type/journal_article DB - PRIME DP - Unbound Medicine ER -