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Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects.

Abstract

The aim of the present study was to compare the response of a range of atherogenic and thrombogenic risk markers to two dietary levels of saturated fatty acid (SFA) substitution with monounsaturated fatty acids (MUFA) in students living in a university hall of residence. Although the benefits of such diets have been reported for plasma lipoproteins in high-risk groups, more needs to be known about effects of more modest SFA-MUFA substitutions over the long term and in young healthy adults. In a parallel design over 16 weeks, fifty-one healthy young subjects were randomised to one of two diets: (1) a moderate-MUFA diet in which 16 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 25); (2) a high-MUFA diet in which 33 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 26). All subjects followed an 8-week run-in diet (reference diet), with a fatty acid composition close to the UK average values. There were no differences in plasma lipid responses between the two diets over 16 weeks of the study with similar reductions in total cholesterol (P<0.001) and LDL-cholesterol (P<0.01) in both groups; a small but significant reduction in HDL-cholesterol was also observed in both groups (P<0.01). Platelet responses to ADP (P<0.01) and arachidonic acid (P<0.05) differed with time on the two diets; at 16 weeks, platelet aggregatory response to ADP was significantly lower on the high-MUFA than the moderate-MUFA (P<0.01) diet; ADP responses were also significantly lower within this group at 8 (P<0.05) and 16 (P<0.01) weeks compared with baseline. There were no differences in fasting factor VII activity (factors VIIc and VIIag), fibrinogen concentration or tissue-type plasminogen activator activity between the diets. There were no differences in postprandial factor VIIc responses to a standard meal (area under the curve) between the diets after 16 weeks, but postprandial factor VIIc response was lower than on the high-MUFA diet compared with baseline (P<0.01). In conclusion, a high-MUFA diet sustains potentially beneficial effects on platelet aggregation and postprandial activation of factor VII. Moderate or high substitution of MUFA for SFA achieves similar reductions in fasting blood lipids in young healthy subjects.

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  • Authors+Show Affiliations

    ,

    School of Food Biosciences, University of Reading, Reading RG6 6AP, UK.

    , , , , , ,

    Source

    The British journal of nutrition 90:3 2003 Sep pg 597-606

    MeSH

    Adult
    Analysis of Variance
    Area Under Curve
    Arteriosclerosis
    Cholesterol
    Cholesterol, HDL
    Cholesterol, LDL
    Dietary Fats, Unsaturated
    Factor VII
    Fatty Acids, Monounsaturated
    Female
    Humans
    Male
    Platelet Aggregation
    Postprandial Period
    Risk Factors
    Single-Blind Method
    Thrombosis

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    13129466

    Citation

    Smith, Ruth D., et al. "Long-term Monounsaturated Fatty Acid Diets Reduce Platelet Aggregation in Healthy Young Subjects." The British Journal of Nutrition, vol. 90, no. 3, 2003, pp. 597-606.
    Smith RD, Kelly CN, Fielding BA, et al. Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects. Br J Nutr. 2003;90(3):597-606.
    Smith, R. D., Kelly, C. N., Fielding, B. A., Hauton, D., Silva, K. D., Nydahl, M. C., ... Williams, C. M. (2003). Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects. The British Journal of Nutrition, 90(3), pp. 597-606.
    Smith RD, et al. Long-term Monounsaturated Fatty Acid Diets Reduce Platelet Aggregation in Healthy Young Subjects. Br J Nutr. 2003;90(3):597-606. PubMed PMID: 13129466.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Long-term monounsaturated fatty acid diets reduce platelet aggregation in healthy young subjects. AU - Smith,Ruth D, AU - Kelly,Colette N M, AU - Fielding,Barbara A, AU - Hauton,David, AU - Silva,K D Renuka R, AU - Nydahl,Margaretha C, AU - Miller,George J, AU - Williams,Christine M, PY - 2003/9/18/pubmed PY - 2003/10/17/medline PY - 2003/9/18/entrez SP - 597 EP - 606 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 90 IS - 3 N2 - The aim of the present study was to compare the response of a range of atherogenic and thrombogenic risk markers to two dietary levels of saturated fatty acid (SFA) substitution with monounsaturated fatty acids (MUFA) in students living in a university hall of residence. Although the benefits of such diets have been reported for plasma lipoproteins in high-risk groups, more needs to be known about effects of more modest SFA-MUFA substitutions over the long term and in young healthy adults. In a parallel design over 16 weeks, fifty-one healthy young subjects were randomised to one of two diets: (1) a moderate-MUFA diet in which 16 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 25); (2) a high-MUFA diet in which 33 g dietary SFA/100 g total fatty acids were substituted with MUFA (n 26). All subjects followed an 8-week run-in diet (reference diet), with a fatty acid composition close to the UK average values. There were no differences in plasma lipid responses between the two diets over 16 weeks of the study with similar reductions in total cholesterol (P<0.001) and LDL-cholesterol (P<0.01) in both groups; a small but significant reduction in HDL-cholesterol was also observed in both groups (P<0.01). Platelet responses to ADP (P<0.01) and arachidonic acid (P<0.05) differed with time on the two diets; at 16 weeks, platelet aggregatory response to ADP was significantly lower on the high-MUFA than the moderate-MUFA (P<0.01) diet; ADP responses were also significantly lower within this group at 8 (P<0.05) and 16 (P<0.01) weeks compared with baseline. There were no differences in fasting factor VII activity (factors VIIc and VIIag), fibrinogen concentration or tissue-type plasminogen activator activity between the diets. There were no differences in postprandial factor VIIc responses to a standard meal (area under the curve) between the diets after 16 weeks, but postprandial factor VIIc response was lower than on the high-MUFA diet compared with baseline (P<0.01). In conclusion, a high-MUFA diet sustains potentially beneficial effects on platelet aggregation and postprandial activation of factor VII. Moderate or high substitution of MUFA for SFA achieves similar reductions in fasting blood lipids in young healthy subjects. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/13129466/Long_term_monounsaturated_fatty_acid_diets_reduce_platelet_aggregation_in_healthy_young_subjects_ L2 - https://www.cambridge.org/core/product/identifier/S000711450300165X/type/journal_article DB - PRIME DP - Unbound Medicine ER -