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Stress management effects on psychological, endocrinological, and immune functioning in men with HIV infection: empirical support for a psychoneuroimmunological model.
Stress 2003; 6(3):173-88S

Abstract

We present a psychoneuroimmunologic (PNI) model for Human Immunodeficiency Virus (HIV) infection, describe a 10-week group-based cognitive behavioral stress management (CBSM) intervention and summarize research demonstrating the effects of this intervention on mood, neuroendocrine (Hypothalamic Pituitary Adrenal [HPA], Hypothalamic Pituitary Gonadal [HPG] and Sympathetic Nervous System [SNS] hormones) and immune system status (lymphocyte subsets, anti-viral immune function) in HIV-infected persons. This work demonstrates that changes in relaxation skills, cognitive coping strategies and social support may mediate the mood effects of CBSM, and that these mood changes may mediate adrenal hormone regulation indicated by reductions in 24-h urinary cortisol (with reduced depressed mood) and norepinephrine (with reduced anxiety) and increases in serum DHEA-S and testosterone levels (with reduced depressed mood). Results also suggest that CBSM-related changes in production of these hormones may explain, in part, the effects of this intervention on short-term changes in IgG antibody titers to herpesviruses (with increased DHEA-S-to-cortisol ratio), and longer-term changes in lymphocyte subpopulations such as CD8 suppressor/cytotoxic cells (with reductions in urinary noradrenaline output) and transitional naïve CD4 cells (with reductions in urinary cortisol output). Thus a multi-modal CBSM intervention is associated with alterations in mood, neuroendocrine functioning and immunologic status that may have health implications for HIV infection.

Authors+Show Affiliations

Department of Psychology, University of Miami, Coral Gables, FL 33124, USA. mantoni@miami.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

13129811

Citation

Antoni, Michael H.. "Stress Management Effects On Psychological, Endocrinological, and Immune Functioning in Men With HIV Infection: Empirical Support for a Psychoneuroimmunological Model." Stress (Amsterdam, Netherlands), vol. 6, no. 3, 2003, pp. 173-88.
Antoni MH. Stress management effects on psychological, endocrinological, and immune functioning in men with HIV infection: empirical support for a psychoneuroimmunological model. Stress. 2003;6(3):173-88.
Antoni, M. H. (2003). Stress management effects on psychological, endocrinological, and immune functioning in men with HIV infection: empirical support for a psychoneuroimmunological model. Stress (Amsterdam, Netherlands), 6(3), pp. 173-88.
Antoni MH. Stress Management Effects On Psychological, Endocrinological, and Immune Functioning in Men With HIV Infection: Empirical Support for a Psychoneuroimmunological Model. Stress. 2003;6(3):173-88. PubMed PMID: 13129811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stress management effects on psychological, endocrinological, and immune functioning in men with HIV infection: empirical support for a psychoneuroimmunological model. A1 - Antoni,Michael H, PY - 2003/9/18/pubmed PY - 2004/1/15/medline PY - 2003/9/18/entrez SP - 173 EP - 88 JF - Stress (Amsterdam, Netherlands) JO - Stress VL - 6 IS - 3 N2 - We present a psychoneuroimmunologic (PNI) model for Human Immunodeficiency Virus (HIV) infection, describe a 10-week group-based cognitive behavioral stress management (CBSM) intervention and summarize research demonstrating the effects of this intervention on mood, neuroendocrine (Hypothalamic Pituitary Adrenal [HPA], Hypothalamic Pituitary Gonadal [HPG] and Sympathetic Nervous System [SNS] hormones) and immune system status (lymphocyte subsets, anti-viral immune function) in HIV-infected persons. This work demonstrates that changes in relaxation skills, cognitive coping strategies and social support may mediate the mood effects of CBSM, and that these mood changes may mediate adrenal hormone regulation indicated by reductions in 24-h urinary cortisol (with reduced depressed mood) and norepinephrine (with reduced anxiety) and increases in serum DHEA-S and testosterone levels (with reduced depressed mood). Results also suggest that CBSM-related changes in production of these hormones may explain, in part, the effects of this intervention on short-term changes in IgG antibody titers to herpesviruses (with increased DHEA-S-to-cortisol ratio), and longer-term changes in lymphocyte subpopulations such as CD8 suppressor/cytotoxic cells (with reductions in urinary noradrenaline output) and transitional naïve CD4 cells (with reductions in urinary cortisol output). Thus a multi-modal CBSM intervention is associated with alterations in mood, neuroendocrine functioning and immunologic status that may have health implications for HIV infection. SN - 1025-3890 UR - https://www.unboundmedicine.com/medline/citation/13129811/Stress_management_effects_on_psychological_endocrinological_and_immune_functioning_in_men_with_HIV_infection:_empirical_support_for_a_psychoneuroimmunological_model_ L2 - http://www.tandfonline.com/doi/full/10.1080/1025389031000156727 DB - PRIME DP - Unbound Medicine ER -