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Stress management effects on psychological, endocrinological, and immune functioning in men with HIV infection: empirical support for a psychoneuroimmunological model.

Abstract

We present a psychoneuroimmunologic (PNI) model for Human Immunodeficiency Virus (HIV) infection, describe a 10-week group-based cognitive behavioral stress management (CBSM) intervention and summarize research demonstrating the effects of this intervention on mood, neuroendocrine (Hypothalamic Pituitary Adrenal [HPA], Hypothalamic Pituitary Gonadal [HPG] and Sympathetic Nervous System [SNS] hormones) and immune system status (lymphocyte subsets, anti-viral immune function) in HIV-infected persons. This work demonstrates that changes in relaxation skills, cognitive coping strategies and social support may mediate the mood effects of CBSM, and that these mood changes may mediate adrenal hormone regulation indicated by reductions in 24-h urinary cortisol (with reduced depressed mood) and norepinephrine (with reduced anxiety) and increases in serum DHEA-S and testosterone levels (with reduced depressed mood). Results also suggest that CBSM-related changes in production of these hormones may explain, in part, the effects of this intervention on short-term changes in IgG antibody titers to herpesviruses (with increased DHEA-S-to-cortisol ratio), and longer-term changes in lymphocyte subpopulations such as CD8 suppressor/cytotoxic cells (with reductions in urinary noradrenaline output) and transitional naïve CD4 cells (with reductions in urinary cortisol output). Thus a multi-modal CBSM intervention is associated with alterations in mood, neuroendocrine functioning and immunologic status that may have health implications for HIV infection.

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  • Publisher Full Text
  • Authors+Show Affiliations

    Department of Psychology, University of Miami, Coral Gables, FL 33124, USA. mantoni@miami.edu

    Source

    Stress (Amsterdam, Netherlands) 6:3 2003 Sep pg 173-88

    MeSH

    Cognitive Behavioral Therapy
    Endocrine Glands
    HIV Infections
    Humans
    Immune System
    Male
    Models, Immunological
    Models, Neurological
    Models, Psychological
    Psychoneuroimmunology
    Stress, Psychological

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    13129811

    Citation

    Antoni, Michael H.. "Stress Management Effects On Psychological, Endocrinological, and Immune Functioning in Men With HIV Infection: Empirical Support for a Psychoneuroimmunological Model." Stress (Amsterdam, Netherlands), vol. 6, no. 3, 2003, pp. 173-88.
    Antoni MH. Stress management effects on psychological, endocrinological, and immune functioning in men with HIV infection: empirical support for a psychoneuroimmunological model. Stress. 2003;6(3):173-88.
    Antoni, M. H. (2003). Stress management effects on psychological, endocrinological, and immune functioning in men with HIV infection: empirical support for a psychoneuroimmunological model. Stress (Amsterdam, Netherlands), 6(3), pp. 173-88.
    Antoni MH. Stress Management Effects On Psychological, Endocrinological, and Immune Functioning in Men With HIV Infection: Empirical Support for a Psychoneuroimmunological Model. Stress. 2003;6(3):173-88. PubMed PMID: 13129811.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Stress management effects on psychological, endocrinological, and immune functioning in men with HIV infection: empirical support for a psychoneuroimmunological model. A1 - Antoni,Michael H, PY - 2003/9/18/pubmed PY - 2004/1/15/medline PY - 2003/9/18/entrez SP - 173 EP - 88 JF - Stress (Amsterdam, Netherlands) JO - Stress VL - 6 IS - 3 N2 - We present a psychoneuroimmunologic (PNI) model for Human Immunodeficiency Virus (HIV) infection, describe a 10-week group-based cognitive behavioral stress management (CBSM) intervention and summarize research demonstrating the effects of this intervention on mood, neuroendocrine (Hypothalamic Pituitary Adrenal [HPA], Hypothalamic Pituitary Gonadal [HPG] and Sympathetic Nervous System [SNS] hormones) and immune system status (lymphocyte subsets, anti-viral immune function) in HIV-infected persons. This work demonstrates that changes in relaxation skills, cognitive coping strategies and social support may mediate the mood effects of CBSM, and that these mood changes may mediate adrenal hormone regulation indicated by reductions in 24-h urinary cortisol (with reduced depressed mood) and norepinephrine (with reduced anxiety) and increases in serum DHEA-S and testosterone levels (with reduced depressed mood). Results also suggest that CBSM-related changes in production of these hormones may explain, in part, the effects of this intervention on short-term changes in IgG antibody titers to herpesviruses (with increased DHEA-S-to-cortisol ratio), and longer-term changes in lymphocyte subpopulations such as CD8 suppressor/cytotoxic cells (with reductions in urinary noradrenaline output) and transitional naïve CD4 cells (with reductions in urinary cortisol output). Thus a multi-modal CBSM intervention is associated with alterations in mood, neuroendocrine functioning and immunologic status that may have health implications for HIV infection. SN - 1025-3890 UR - https://www.unboundmedicine.com/medline/citation/13129811/full_citation L2 - http://www.tandfonline.com/doi/full/10.1080/1025389031000156727 DB - PRIME DP - Unbound Medicine ER -