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Possible mechanisms of action in quercetin reversal of morphine tolerance and dependence.
Addict Biol. 2003 Sep; 8(3):327-36.AB

Abstract

In an earlier study, we reported the ability of quercetin to reverse the development of morphine tolerance and dependence in mice. In the present study we have attempted to explore the possible involvement of nitric oxide (NO) system in quercetin reversal of morphine tolerance and dependence in mice. Co-administration of L-N(G)-nitro arginine methyl ester (L-NAME) or quercetin with morphine during the induction phase (days 1-9) delayed the development of tolerance to the antinociceptive action of morphine and also reversed naloxone precipitated withdrawal jumps. L-Arginine administration during the induction phase enhanced the development of tolerance to the antinociceptive effect of morphine but had no effect on the naloxone-precipitated withdrawal jumps. During the expression phase (day 10) acute administration of quercetin or L-NAME reversed, whereas L-arginine facilitated naloxone- precipitated withdrawal jumps in morphine-tolerant mice, but none of these drugs affected the nociceptive threshold in morphine-tolerant mice. Further, co-administration of quercetin or L-NAME with L-arginine during the induction phase antagonized the latter effects on the development of morphine tolerance. Also, prior administration of quercetin or L-NAME reversed the L-arginine potentiation of nalaxone-precipitated withdrawal jumps in morphine-tolerant mice. The results of the present study suggest that quercetin reversal of morphine tolerance and dependence may involve its ability to suppress nitric oxide synthase (NOS) activity.

Authors+Show Affiliations

Parmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

13129835

Citation

Naidu, Pattipati S., et al. "Possible Mechanisms of Action in Quercetin Reversal of Morphine Tolerance and Dependence." Addiction Biology, vol. 8, no. 3, 2003, pp. 327-36.
Naidu PS, Singh A, Joshi D, et al. Possible mechanisms of action in quercetin reversal of morphine tolerance and dependence. Addict Biol. 2003;8(3):327-36.
Naidu, P. S., Singh, A., Joshi, D., & Kulkarni, S. K. (2003). Possible mechanisms of action in quercetin reversal of morphine tolerance and dependence. Addiction Biology, 8(3), 327-36.
Naidu PS, et al. Possible Mechanisms of Action in Quercetin Reversal of Morphine Tolerance and Dependence. Addict Biol. 2003;8(3):327-36. PubMed PMID: 13129835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Possible mechanisms of action in quercetin reversal of morphine tolerance and dependence. AU - Naidu,Pattipati S, AU - Singh,Amanpreet, AU - Joshi,Dipesh, AU - Kulkarni,Shrinivas K, PY - 2003/9/18/pubmed PY - 2004/1/30/medline PY - 2003/9/18/entrez SP - 327 EP - 36 JF - Addiction biology JO - Addict Biol VL - 8 IS - 3 N2 - In an earlier study, we reported the ability of quercetin to reverse the development of morphine tolerance and dependence in mice. In the present study we have attempted to explore the possible involvement of nitric oxide (NO) system in quercetin reversal of morphine tolerance and dependence in mice. Co-administration of L-N(G)-nitro arginine methyl ester (L-NAME) or quercetin with morphine during the induction phase (days 1-9) delayed the development of tolerance to the antinociceptive action of morphine and also reversed naloxone precipitated withdrawal jumps. L-Arginine administration during the induction phase enhanced the development of tolerance to the antinociceptive effect of morphine but had no effect on the naloxone-precipitated withdrawal jumps. During the expression phase (day 10) acute administration of quercetin or L-NAME reversed, whereas L-arginine facilitated naloxone- precipitated withdrawal jumps in morphine-tolerant mice, but none of these drugs affected the nociceptive threshold in morphine-tolerant mice. Further, co-administration of quercetin or L-NAME with L-arginine during the induction phase antagonized the latter effects on the development of morphine tolerance. Also, prior administration of quercetin or L-NAME reversed the L-arginine potentiation of nalaxone-precipitated withdrawal jumps in morphine-tolerant mice. The results of the present study suggest that quercetin reversal of morphine tolerance and dependence may involve its ability to suppress nitric oxide synthase (NOS) activity. SN - 1355-6215 UR - https://www.unboundmedicine.com/medline/citation/13129835/Possible_mechanisms_of_action_in_quercetin_reversal_of_morphine_tolerance_and_dependence_ L2 - https://doi.org/10.1080/13556210310001602248 DB - PRIME DP - Unbound Medicine ER -