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Nonnecrotizing herpetic retinopathies masquerading as severe posterior uveitis.
Ophthalmology. 2003 Sep; 110(9):1737-43.O

Abstract

OBJECTIVE

Aqueous humor analysis can be performed in severe atypical forms of posterior uveitis unresponsive to conventional treatment to exclude a viral infection.

DESIGN

Noncomparative interventional case series.

PARTICIPANTS

Thirty-seven immunocompetent patients seen with corticosteroid-resistant forms of posterior uveitis underwent extensive evaluation, including anterior chamber paracentesis, to rule out a nonnecrotizing viral retinopathy.

INTERVENTION

Aqueous fluid samples were prospectively obtained. Polymerase chain reaction (PCR) and serologic evaluation of intraocular antibody production against herpesviruses were performed by molecular techniques and enzyme-linked immunosorbent assay.

MAIN OUTCOME MEASURES

Polymerase chain reaction and local antibody production for herpes simplex virus types 1 and 2, varicella-zoster virus, cytomegalovirus, and Epstein-Barr virus were determined on aqueous fluid samples.

RESULTS

Viral infection was confirmed in 5 cases (13.5%). Clinical presentation included birdshot-like retinochoroidopathy, occlusive bilateral vasculitis, and cystoid macular edema. An antiviral regimen was initiated in all cases. Inflammation was stabilized, and steroid dosage could be significantly reduced.

CONCLUSIONS

Identification of a viral agent during severe posterior uveitis can dramatically change therapeutic management.

Authors+Show Affiliations

Department of Ophthalmology, Pitié-Salpêtrière Hospital, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

13129871

Citation

Bodaghi, Bahram, et al. "Nonnecrotizing Herpetic Retinopathies Masquerading as Severe Posterior Uveitis." Ophthalmology, vol. 110, no. 9, 2003, pp. 1737-43.
Bodaghi B, Rozenberg F, Cassoux N, et al. Nonnecrotizing herpetic retinopathies masquerading as severe posterior uveitis. Ophthalmology. 2003;110(9):1737-43.
Bodaghi, B., Rozenberg, F., Cassoux, N., Fardeau, C., & LeHoang, P. (2003). Nonnecrotizing herpetic retinopathies masquerading as severe posterior uveitis. Ophthalmology, 110(9), 1737-43.
Bodaghi B, et al. Nonnecrotizing Herpetic Retinopathies Masquerading as Severe Posterior Uveitis. Ophthalmology. 2003;110(9):1737-43. PubMed PMID: 13129871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonnecrotizing herpetic retinopathies masquerading as severe posterior uveitis. AU - Bodaghi,Bahram, AU - Rozenberg,Flore, AU - Cassoux,Nathalie, AU - Fardeau,Christine, AU - LeHoang,Phuc, PY - 2003/9/18/pubmed PY - 2003/10/1/medline PY - 2003/9/18/entrez SP - 1737 EP - 43 JF - Ophthalmology JO - Ophthalmology VL - 110 IS - 9 N2 - OBJECTIVE: Aqueous humor analysis can be performed in severe atypical forms of posterior uveitis unresponsive to conventional treatment to exclude a viral infection. DESIGN: Noncomparative interventional case series. PARTICIPANTS: Thirty-seven immunocompetent patients seen with corticosteroid-resistant forms of posterior uveitis underwent extensive evaluation, including anterior chamber paracentesis, to rule out a nonnecrotizing viral retinopathy. INTERVENTION: Aqueous fluid samples were prospectively obtained. Polymerase chain reaction (PCR) and serologic evaluation of intraocular antibody production against herpesviruses were performed by molecular techniques and enzyme-linked immunosorbent assay. MAIN OUTCOME MEASURES: Polymerase chain reaction and local antibody production for herpes simplex virus types 1 and 2, varicella-zoster virus, cytomegalovirus, and Epstein-Barr virus were determined on aqueous fluid samples. RESULTS: Viral infection was confirmed in 5 cases (13.5%). Clinical presentation included birdshot-like retinochoroidopathy, occlusive bilateral vasculitis, and cystoid macular edema. An antiviral regimen was initiated in all cases. Inflammation was stabilized, and steroid dosage could be significantly reduced. CONCLUSIONS: Identification of a viral agent during severe posterior uveitis can dramatically change therapeutic management. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/13129871/Nonnecrotizing_herpetic_retinopathies_masquerading_as_severe_posterior_uveitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(03)00580-3 DB - PRIME DP - Unbound Medicine ER -