Citation
Kaplan, Jonathan E., et al. "When to Begin Highly Active Antiretroviral Therapy? Evidence Supporting Initiation of Therapy at CD4+ Lymphocyte Counts <350 Cells/microL." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 37, no. 7, 2003, pp. 951-8.
Kaplan JE, Hanson DL, Cohn DL, et al. When to begin highly active antiretroviral therapy? Evidence supporting initiation of therapy at CD4+ lymphocyte counts <350 cells/microL. Clin Infect Dis. 2003;37(7):951-8.
Kaplan, J. E., Hanson, D. L., Cohn, D. L., Karon, J., Buskin, S., Thompson, M., Fleming, P., & Dworkin, M. S. (2003). When to begin highly active antiretroviral therapy? Evidence supporting initiation of therapy at CD4+ lymphocyte counts <350 cells/microL. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 37(7), 951-8.
Kaplan JE, et al. When to Begin Highly Active Antiretroviral Therapy? Evidence Supporting Initiation of Therapy at CD4+ Lymphocyte Counts <350 Cells/microL. Clin Infect Dis. 2003 Oct 1;37(7):951-8. PubMed PMID: 13130408.
TY - JOUR
T1 - When to begin highly active antiretroviral therapy? Evidence supporting initiation of therapy at CD4+ lymphocyte counts <350 cells/microL.
AU - Kaplan,Jonathan E,
AU - Hanson,Debra L,
AU - Cohn,David L,
AU - Karon,John,
AU - Buskin,Susan,
AU - Thompson,Melanie,
AU - Fleming,Patricia,
AU - Dworkin,Mark S,
AU - ,,
Y1 - 2003/09/12/
PY - 2003/02/26/received
PY - 2003/05/31/accepted
PY - 2003/9/18/pubmed
PY - 2003/11/5/medline
PY - 2003/9/18/entrez
SP - 951
EP - 8
JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
JO - Clin Infect Dis
VL - 37
IS - 7
N2 - We assessed the risk of acquired immunodeficiency syndrome (AIDS)-related opportunistic illness or death among persons first prescribed highly active antiretroviral therapy (HAART) in January 1996 or later in the Centers for Disease Control and Prevention's Adult and Adolescent HIV Spectrum of Disease Project. Patients were included if they were naive to antiretroviral drugs and had no history of AIDS-related opportunistic illness. Risk was assessed as a function of CD4+ lymphocyte count and human immunodeficiency virus load at the time of initiation of HAART in a Cox proportional hazards model. Hazard ratios for AIDS or death were 6.3, 3.5, and 1.7 for persons with baseline CD4+ cell counts of 0-49, 50-199, and 200-349 cells/microL, respectively, compared with the referent (CD4+ cell count > or =500 cells/microL). HAART should not be deferred until the CD4+ cell count reaches <200 cells/microL. The increased hazard associated with CD4+ cell counts of 200-349 cells/microL was modest but supports initiation of HAART at CD4+ cell counts <350 cells/microL, particularly in patients with high virus loads.
SN - 1537-6591
UR - https://www.unboundmedicine.com/medline/citation/13130408/When_to_begin_highly_active_antiretroviral_therapy_Evidence_supporting_initiation_of_therapy_at_CD4+_lymphocyte_counts_<350_cells/microL_
L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/377606
DB - PRIME
DP - Unbound Medicine
ER -