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The effects of chronic administration of ethanol on synaptosomal fatty acid composition: modulation by oil enriched with gamma-linolenic acid.
Alcohol Alcohol. 1992 Jan; 27(1):11-4.AA

Abstract

Chronic ethanol administration significantly decreased the percentage of arachidonate and significantly increased the linoleate: arachidonate ratio in the cortical synaptosomal phosphatidylinositol (PI) of rats. However, concomitant administration of evening primrose oil (rich in gamma-linolenic acid) reversed the effects seen with ethanol alone. These results suggest that the decrease of arachidonate, especially in PI, caused by chronic administration of ethanol may be overcome by systemic administration of gamma-linolenic acid.

Authors+Show Affiliations

Biological Research, Hoechst-Roussel Pharmaceutical Inc., Sommerville, NJ 08876.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1316121

Citation

Corbett, R, et al. "The Effects of Chronic Administration of Ethanol On Synaptosomal Fatty Acid Composition: Modulation By Oil Enriched With Gamma-linolenic Acid." Alcohol and Alcoholism (Oxford, Oxfordshire), vol. 27, no. 1, 1992, pp. 11-4.
Corbett R, Berthou F, Leonard BE, et al. The effects of chronic administration of ethanol on synaptosomal fatty acid composition: modulation by oil enriched with gamma-linolenic acid. Alcohol Alcohol. 1992;27(1):11-4.
Corbett, R., Berthou, F., Leonard, B. E., & Ménez, J. F. (1992). The effects of chronic administration of ethanol on synaptosomal fatty acid composition: modulation by oil enriched with gamma-linolenic acid. Alcohol and Alcoholism (Oxford, Oxfordshire), 27(1), 11-4.
Corbett R, et al. The Effects of Chronic Administration of Ethanol On Synaptosomal Fatty Acid Composition: Modulation By Oil Enriched With Gamma-linolenic Acid. Alcohol Alcohol. 1992;27(1):11-4. PubMed PMID: 1316121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of chronic administration of ethanol on synaptosomal fatty acid composition: modulation by oil enriched with gamma-linolenic acid. AU - Corbett,R, AU - Berthou,F, AU - Leonard,B E, AU - Ménez,J F, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 11 EP - 4 JF - Alcohol and alcoholism (Oxford, Oxfordshire) JO - Alcohol Alcohol VL - 27 IS - 1 N2 - Chronic ethanol administration significantly decreased the percentage of arachidonate and significantly increased the linoleate: arachidonate ratio in the cortical synaptosomal phosphatidylinositol (PI) of rats. However, concomitant administration of evening primrose oil (rich in gamma-linolenic acid) reversed the effects seen with ethanol alone. These results suggest that the decrease of arachidonate, especially in PI, caused by chronic administration of ethanol may be overcome by systemic administration of gamma-linolenic acid. SN - 0735-0414 UR - https://www.unboundmedicine.com/medline/citation/1316121/The_effects_of_chronic_administration_of_ethanol_on_synaptosomal_fatty_acid_composition:_modulation_by_oil_enriched_with_gamma_linolenic_acid_ L2 - https://medlineplus.gov/alcoholusedisorderaud.html DB - PRIME DP - Unbound Medicine ER -