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An autopsied case of juvenile parkinsonism and dementia, with a widespread occurrence of Lewy bodies and spheroids.
Clin Neuropathol. 1992 May-Jun; 11(3):131-4.CN

Abstract

An autopsied case of juvenile parkinsonism and dementia is described. The patient is a 48-year-old man who had a ten-year history of parkinsonian syndrome and progressive dementia. Neuropathological examination revealed a widespread occurrence of Lewy bodies and spheroids in the central nervous system. Lewy bodies were found not only in the brain stem and diencephalon, but also in the cerebral cortex. Massive numbers of small spheroids were observed in the globus pallidus, substantia nigra, mamillary bodies and hippocampus. Electron microscopical examination showed that most spheroids were composed of degenerative organelles with only a few neurofilaments, and were different from those of Hallervorden-Spatz disease. There was also marked neuronal loss with gliosis in the CA3-4 of the hippocampus. Some neurofibrillary tangles occurred in the hippocampus, subcortical and brain stem nuclei, but senile plaques were absent. This case may represent an atypical form of pure diffuse Lewy body disease.

Authors+Show Affiliations

Odawara T
Department of Psychiatry and Neurology, Yokohama City University School of Medicine, Japan.
Iseki E
No affiliation info available
Yagishita S
No affiliation info available
Amano N
No affiliation info available
Kosaka K
No affiliation info available
Hasegawa K
No affiliation info available
Matsuda Y
No affiliation info available
Kowa H
No affiliation info available

MeSH

BrainDementiaHumansInclusion BodiesLewy BodiesMaleMiddle AgedNerve DegenerationNeurofibrillary TanglesNeuronsParkinson DiseaseSpinal Cord

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

1319291

Citation

Odawara, T, et al. "An Autopsied Case of Juvenile Parkinsonism and Dementia, With a Widespread Occurrence of Lewy Bodies and Spheroids." Clinical Neuropathology, vol. 11, no. 3, 1992, pp. 131-4.
Odawara T, Iseki E, Yagishita S, et al. An autopsied case of juvenile parkinsonism and dementia, with a widespread occurrence of Lewy bodies and spheroids. Clin Neuropathol. 1992;11(3):131-4.
Odawara, T., Iseki, E., Yagishita, S., Amano, N., Kosaka, K., Hasegawa, K., Matsuda, Y., & Kowa, H. (1992). An autopsied case of juvenile parkinsonism and dementia, with a widespread occurrence of Lewy bodies and spheroids. Clinical Neuropathology, 11(3), 131-4.
Odawara T, et al. An Autopsied Case of Juvenile Parkinsonism and Dementia, With a Widespread Occurrence of Lewy Bodies and Spheroids. Clin Neuropathol. 1992 May-Jun;11(3):131-4. PubMed PMID: 1319291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An autopsied case of juvenile parkinsonism and dementia, with a widespread occurrence of Lewy bodies and spheroids. AU - Odawara,T, AU - Iseki,E, AU - Yagishita,S, AU - Amano,N, AU - Kosaka,K, AU - Hasegawa,K, AU - Matsuda,Y, AU - Kowa,H, PY - 1992/5/1/pubmed PY - 1992/5/1/medline PY - 1992/5/1/entrez SP - 131 EP - 4 JF - Clinical neuropathology JO - Clin Neuropathol VL - 11 IS - 3 N2 - An autopsied case of juvenile parkinsonism and dementia is described. The patient is a 48-year-old man who had a ten-year history of parkinsonian syndrome and progressive dementia. Neuropathological examination revealed a widespread occurrence of Lewy bodies and spheroids in the central nervous system. Lewy bodies were found not only in the brain stem and diencephalon, but also in the cerebral cortex. Massive numbers of small spheroids were observed in the globus pallidus, substantia nigra, mamillary bodies and hippocampus. Electron microscopical examination showed that most spheroids were composed of degenerative organelles with only a few neurofilaments, and were different from those of Hallervorden-Spatz disease. There was also marked neuronal loss with gliosis in the CA3-4 of the hippocampus. Some neurofibrillary tangles occurred in the hippocampus, subcortical and brain stem nuclei, but senile plaques were absent. This case may represent an atypical form of pure diffuse Lewy body disease. SN - 0722-5091 UR - https://www.unboundmedicine.com/medline/citation/1319291/An_autopsied_case_of_juvenile_parkinsonism_and_dementia_with_a_widespread_occurrence_of_Lewy_bodies_and_spheroids_ DB - PRIME DP - Unbound Medicine ER -