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Mediation of swim-stress antinociception by the opioid delta 2 receptor in the mouse.
J Pharmacol Exp Ther. 1992 Jul; 262(1):190-7.JP

Abstract

The present study has characterized the antinociceptive response to cold water swim-stress (CWSS) in mice using opioid-selective antagonists as well as tolerance and cross-tolerance approaches. Mice subjected to CWSS using water at 5 degrees C for 3 min showed a marked antinociceptive response in the tail-flick test, which reached approximately 90% after +10 min, and which persisted for 15 to 20 min. This antinociceptive response (at +10 min) was antagonized by naloxone or by the delta antagonist ICI 174,864. Additionally, the CWSS response was antagonized by the opioid delta 2 antagonist, naltrindole-5'-isothiocyanate, but not by the delta 1 antagonist, [D-Ala2,Leu5,Cys6]enkephalin, or by the mu antagonist, beta-funaltrexamine or by the kappa antagonist, norbinaltorphimine. Although the CWSS-induced antinociceptive effect was blocked by some delta antagonists and tolerance resulted from the CWSS-induced response, the decrease in body temperature after each CWSS exposure was not affected by the opioid antagonists and reliably occurred in CWSS-tolerant mice, suggesting that the observed antinociception was independent of changes in body temperature. In mice rendered tolerant to the antinociceptive actions of the mu agonist, [D-Ala2,NMPhe4,Gly-ol] enkephalin, or to [D-Pen2,D-Pen5]enkephalin (predominantly a delta 1 agonist), the CWSS-induced antinociceptive response was unaltered. In contrast, in mice tolerant to the delta 2 agonist, [D-Ala2,Glu4]deltorphin, the CWSS-induced antinociceptive response was markedly and significantly reduced.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Pharmacology, University of Arizona Health Sciences Center, Tucson.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1320682

Citation

Vanderah, T W., et al. "Mediation of Swim-stress Antinociception By the Opioid Delta 2 Receptor in the Mouse." The Journal of Pharmacology and Experimental Therapeutics, vol. 262, no. 1, 1992, pp. 190-7.
Vanderah TW, Wild KD, Takemori AE, et al. Mediation of swim-stress antinociception by the opioid delta 2 receptor in the mouse. J Pharmacol Exp Ther. 1992;262(1):190-7.
Vanderah, T. W., Wild, K. D., Takemori, A. E., Sultana, M., Portoghese, P. S., Bowen, W. D., Mosberg, H. I., & Porreca, F. (1992). Mediation of swim-stress antinociception by the opioid delta 2 receptor in the mouse. The Journal of Pharmacology and Experimental Therapeutics, 262(1), 190-7.
Vanderah TW, et al. Mediation of Swim-stress Antinociception By the Opioid Delta 2 Receptor in the Mouse. J Pharmacol Exp Ther. 1992;262(1):190-7. PubMed PMID: 1320682.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mediation of swim-stress antinociception by the opioid delta 2 receptor in the mouse. AU - Vanderah,T W, AU - Wild,K D, AU - Takemori,A E, AU - Sultana,M, AU - Portoghese,P S, AU - Bowen,W D, AU - Mosberg,H I, AU - Porreca,F, PY - 1992/7/1/pubmed PY - 1992/7/1/medline PY - 1992/7/1/entrez SP - 190 EP - 7 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 262 IS - 1 N2 - The present study has characterized the antinociceptive response to cold water swim-stress (CWSS) in mice using opioid-selective antagonists as well as tolerance and cross-tolerance approaches. Mice subjected to CWSS using water at 5 degrees C for 3 min showed a marked antinociceptive response in the tail-flick test, which reached approximately 90% after +10 min, and which persisted for 15 to 20 min. This antinociceptive response (at +10 min) was antagonized by naloxone or by the delta antagonist ICI 174,864. Additionally, the CWSS response was antagonized by the opioid delta 2 antagonist, naltrindole-5'-isothiocyanate, but not by the delta 1 antagonist, [D-Ala2,Leu5,Cys6]enkephalin, or by the mu antagonist, beta-funaltrexamine or by the kappa antagonist, norbinaltorphimine. Although the CWSS-induced antinociceptive effect was blocked by some delta antagonists and tolerance resulted from the CWSS-induced response, the decrease in body temperature after each CWSS exposure was not affected by the opioid antagonists and reliably occurred in CWSS-tolerant mice, suggesting that the observed antinociception was independent of changes in body temperature. In mice rendered tolerant to the antinociceptive actions of the mu agonist, [D-Ala2,NMPhe4,Gly-ol] enkephalin, or to [D-Pen2,D-Pen5]enkephalin (predominantly a delta 1 agonist), the CWSS-induced antinociceptive response was unaltered. In contrast, in mice tolerant to the delta 2 agonist, [D-Ala2,Glu4]deltorphin, the CWSS-induced antinociceptive response was markedly and significantly reduced.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/1320682/Mediation_of_swim_stress_antinociception_by_the_opioid_delta_2_receptor_in_the_mouse_ L2 - https://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=1320682 DB - PRIME DP - Unbound Medicine ER -