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Observations on the effect of verapamil with sodium stibogluconate in kala azar.
Trop Geogr Med. 1992 Jan; 44(1-2):15-8.TG

Abstract

40 parasitologically confirmed cases of kala azar, were randomly allocated into four treatment groups to assess the effect of verapamil on fresh and antimony resistant cases of kala azar. Untreated patients received sodium stibogluconate only or in combination with oral verapamil. Antimony-resistant patients were treated with sodium stibogluconate combined with oral verapamil or pentamidine. The patients were followed up for six months. Verapamil neither shortened the duration of treatment nor increased parasitological cure rate nor improved the ultimate cure. In antimony unresponsive patients it did not reverse unresponsiveness.

Authors+Show Affiliations

Thakur CP
Department of Medicine, Patna Medical College Hospital, India.
Kumar M
No affiliation info available

MeSH

Administration, OralAdultAntimony Sodium GluconateDrug ResistanceDrug Therapy, CombinationFemaleFollow-Up StudiesHumansInjections, IntramuscularLeishmaniasis, VisceralMalePentamidineSplenomegalyVerapamil

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1323160

Citation

Thakur, C P., and M Kumar. "Observations On the Effect of Verapamil With Sodium Stibogluconate in Kala Azar." Tropical and Geographical Medicine, vol. 44, no. 1-2, 1992, pp. 15-8.
Thakur CP, Kumar M. Observations on the effect of verapamil with sodium stibogluconate in kala azar. Trop Geogr Med. 1992;44(1-2):15-8.
Thakur, C. P., & Kumar, M. (1992). Observations on the effect of verapamil with sodium stibogluconate in kala azar. Tropical and Geographical Medicine, 44(1-2), 15-8.
Thakur CP, Kumar M. Observations On the Effect of Verapamil With Sodium Stibogluconate in Kala Azar. Trop Geogr Med. 1992;44(1-2):15-8. PubMed PMID: 1323160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Observations on the effect of verapamil with sodium stibogluconate in kala azar. AU - Thakur,C P, AU - Kumar,M, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 15 EP - 8 JF - Tropical and geographical medicine JO - Trop Geogr Med VL - 44 IS - 1-2 N2 - 40 parasitologically confirmed cases of kala azar, were randomly allocated into four treatment groups to assess the effect of verapamil on fresh and antimony resistant cases of kala azar. Untreated patients received sodium stibogluconate only or in combination with oral verapamil. Antimony-resistant patients were treated with sodium stibogluconate combined with oral verapamil or pentamidine. The patients were followed up for six months. Verapamil neither shortened the duration of treatment nor increased parasitological cure rate nor improved the ultimate cure. In antimony unresponsive patients it did not reverse unresponsiveness. SN - 0041-3232 UR - https://www.unboundmedicine.com/medline/citation/1323160/Observations_on_the_effect_of_verapamil_with_sodium_stibogluconate_in_kala_azar_ DB - PRIME DP - Unbound Medicine ER -