Tags

Type your tag names separated by a space and hit enter

Simultaneous quantitation of delta-9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THC-COOH) in serum by GC/MS using deuterated internal standards and its application to a smoking study and forensic cases.
J Forensic Sci. 1992 Jul; 37(4):969-83.JF

Abstract

A new procedure for the simultaneous detection of delta-9-tetrahydrocannabinol (THC) and its major metabolite, 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THC-COOH) in serum has been evaluated. The method combines rapid, efficient, solid-phase extraction and simple derivatization by methylation. Analysis and quantitation is performed by gas chromatography/mass spectrometry (GC/MS) using deuterated cannabinoids as internal standards (IS). Reproducibility and sensitivity of the method are good. The procedure is applied to serum specimens collected from a smoking study with 24 volunteers and 212 forensic cases. Results are interpreted based upon the current knowledge about THC metabolism and pharmacokinetics.

Authors+Show Affiliations

Institute of Legal Medicine, State University of Saarland, Homburg, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1324293

Citation

Moeller, M R., et al. "Simultaneous Quantitation of Delta-9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THC-COOH) in Serum By GC/MS Using Deuterated Internal Standards and Its Application to a Smoking Study and Forensic Cases." Journal of Forensic Sciences, vol. 37, no. 4, 1992, pp. 969-83.
Moeller MR, Doerr G, Warth S. Simultaneous quantitation of delta-9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THC-COOH) in serum by GC/MS using deuterated internal standards and its application to a smoking study and forensic cases. J Forensic Sci. 1992;37(4):969-83.
Moeller, M. R., Doerr, G., & Warth, S. (1992). Simultaneous quantitation of delta-9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THC-COOH) in serum by GC/MS using deuterated internal standards and its application to a smoking study and forensic cases. Journal of Forensic Sciences, 37(4), 969-83.
Moeller MR, Doerr G, Warth S. Simultaneous Quantitation of Delta-9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THC-COOH) in Serum By GC/MS Using Deuterated Internal Standards and Its Application to a Smoking Study and Forensic Cases. J Forensic Sci. 1992;37(4):969-83. PubMed PMID: 1324293.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous quantitation of delta-9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THC-COOH) in serum by GC/MS using deuterated internal standards and its application to a smoking study and forensic cases. AU - Moeller,M R, AU - Doerr,G, AU - Warth,S, PY - 1992/7/1/pubmed PY - 1992/7/1/medline PY - 1992/7/1/entrez SP - 969 EP - 83 JF - Journal of forensic sciences JO - J Forensic Sci VL - 37 IS - 4 N2 - A new procedure for the simultaneous detection of delta-9-tetrahydrocannabinol (THC) and its major metabolite, 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THC-COOH) in serum has been evaluated. The method combines rapid, efficient, solid-phase extraction and simple derivatization by methylation. Analysis and quantitation is performed by gas chromatography/mass spectrometry (GC/MS) using deuterated cannabinoids as internal standards (IS). Reproducibility and sensitivity of the method are good. The procedure is applied to serum specimens collected from a smoking study with 24 volunteers and 212 forensic cases. Results are interpreted based upon the current knowledge about THC metabolism and pharmacokinetics. SN - 0022-1198 UR - https://www.unboundmedicine.com/medline/citation/1324293/Simultaneous_quantitation_of_delta_9_tetrahydrocannabinol__THC__and_11_nor_9_carboxy_delta_9_tetrahydrocannabinol__THC_COOH__in_serum_by_GC/MS_using_deuterated_internal_standards_and_its_application_to_a_smoking_study_and_forensic_cases_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:1324293 DB - PRIME DP - Unbound Medicine ER -