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Synergistic activity of azithromycin and pyrimethamine or sulfadiazine in acute experimental toxoplasmosis.
Antimicrob Agents Chemother 1992; 36(5):997-1001AA

Abstract

The efficacy of azithromycin administered alone or combined with pyrimethamine or sulfadiazine was examined in a murine model of acute toxoplasmosis. Outbred Swiss mice acutely infected with tachyzoites of the virulent RH strain were treated for 10 days from day +1 postinfection. The efficacy of each regimen was assessed in terms of survival rates and sequential titration of parasites in blood, brain, and lungs by using a tissue culture method. Administration of azithromycin at 300, 150, or 75 mg/kg of body weight per day resulted in prolonged survival relative to that of untreated controls; sequential examination of parasite burden showed early eradiaction of Toxoplasma gondii from the lungs, whereas dissemination to the brain was not prevented. A remarkable synergistic effect was observed when azithromycin (150 mg/kg/day) was administered in combination with pyrimethamine or sulfadiazine at noncurative dosages, i.e., 12.5 and 200 mg/kg/day, respectively. In mice treated with azithromycin plus sulfadiazine and azithromycin plus pyrimethamine, parasite burdens in blood and organs, relapses after cessation of therapy, and mortality were all markedly reduced relative to mice treated with any of the agents alone. These results show that azithromycin, which is remarkably active on pulmonary Toxoplasma infection, significantly potentiates the curative effect of sulfadiazine or pyrimethamine.

Authors+Show Affiliations

Laboratoire de Parasitologie-Mycologie, Hôpital Saint-Louis, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1324642

Citation

Derouin, F, et al. "Synergistic Activity of Azithromycin and Pyrimethamine or Sulfadiazine in Acute Experimental Toxoplasmosis." Antimicrobial Agents and Chemotherapy, vol. 36, no. 5, 1992, pp. 997-1001.
Derouin F, Almadany R, Chau F, et al. Synergistic activity of azithromycin and pyrimethamine or sulfadiazine in acute experimental toxoplasmosis. Antimicrob Agents Chemother. 1992;36(5):997-1001.
Derouin, F., Almadany, R., Chau, F., Rouveix, B., & Pocidalo, J. J. (1992). Synergistic activity of azithromycin and pyrimethamine or sulfadiazine in acute experimental toxoplasmosis. Antimicrobial Agents and Chemotherapy, 36(5), pp. 997-1001.
Derouin F, et al. Synergistic Activity of Azithromycin and Pyrimethamine or Sulfadiazine in Acute Experimental Toxoplasmosis. Antimicrob Agents Chemother. 1992;36(5):997-1001. PubMed PMID: 1324642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synergistic activity of azithromycin and pyrimethamine or sulfadiazine in acute experimental toxoplasmosis. AU - Derouin,F, AU - Almadany,R, AU - Chau,F, AU - Rouveix,B, AU - Pocidalo,J J, PY - 1992/5/1/pubmed PY - 1992/5/1/medline PY - 1992/5/1/entrez SP - 997 EP - 1001 JF - Antimicrobial agents and chemotherapy JO - Antimicrob. Agents Chemother. VL - 36 IS - 5 N2 - The efficacy of azithromycin administered alone or combined with pyrimethamine or sulfadiazine was examined in a murine model of acute toxoplasmosis. Outbred Swiss mice acutely infected with tachyzoites of the virulent RH strain were treated for 10 days from day +1 postinfection. The efficacy of each regimen was assessed in terms of survival rates and sequential titration of parasites in blood, brain, and lungs by using a tissue culture method. Administration of azithromycin at 300, 150, or 75 mg/kg of body weight per day resulted in prolonged survival relative to that of untreated controls; sequential examination of parasite burden showed early eradiaction of Toxoplasma gondii from the lungs, whereas dissemination to the brain was not prevented. A remarkable synergistic effect was observed when azithromycin (150 mg/kg/day) was administered in combination with pyrimethamine or sulfadiazine at noncurative dosages, i.e., 12.5 and 200 mg/kg/day, respectively. In mice treated with azithromycin plus sulfadiazine and azithromycin plus pyrimethamine, parasite burdens in blood and organs, relapses after cessation of therapy, and mortality were all markedly reduced relative to mice treated with any of the agents alone. These results show that azithromycin, which is remarkably active on pulmonary Toxoplasma infection, significantly potentiates the curative effect of sulfadiazine or pyrimethamine. SN - 0066-4804 UR - https://www.unboundmedicine.com/medline/citation/1324642/Synergistic_activity_of_azithromycin_and_pyrimethamine_or_sulfadiazine_in_acute_experimental_toxoplasmosis_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=1324642 DB - PRIME DP - Unbound Medicine ER -