Tags

Type your tag names separated by a space and hit enter

[Effects of a specific thromboxane A2 synthetase inhibitor on lymphocyte and neutrophil functions in adult intractable asthmatics].
Arerugi 1992; 41(5):584-94A

Abstract

To clarify whether thromboxane A2 (TXA2) is involved in type III and IV allergy, or so called "cell-mediated allergy", we studied the effect of a specific TXA2 synthetase inhibitor, sodium ozagrel (OKY-046) on peripheral blood mononuclear cells and neutrophils in adult intractable asthmatics. The results revealed, firstly, that lymphocyte blastogenesis and interleukin-2 (IL-2) production from peripheral blood mononuclear cells stimulated by PHA and Candida antigen in intractable asthmatics was significantly suppressed dose-dependently by OKY-046. Secondly, there was a tendency that neutrophil chemotactic factor (NCF) and eosinophil chemotactic factor (ECF) from peripheral blood mononuclear cells stimulated by Candida antigen in intractable asthmatics were suppressed by OKY-046. Thirdly, leukotriene (LTC4) and superoxide (O2-) production from peripheral blood neutrophils in intractable asthmatics was significantly suppressed dose-dependently by OKY-046. That is, OKY-046 has a suppressive effect on type IV allergy caused by lymphocyte activation and on mediator release from neutrophils. These results suggest that TXA2 plays an important role in the development of bronchial asthma and OKY-046 might be a useful drug in the treatment of intractable asthmatics.

Authors+Show Affiliations

Second Department of Medicine, Okayama University Medical School.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

1325764

Citation

Kanehiro, A, et al. "[Effects of a Specific Thromboxane A2 Synthetase Inhibitor On Lymphocyte and Neutrophil Functions in Adult Intractable Asthmatics]." Arerugi = [Allergy], vol. 41, no. 5, 1992, pp. 584-94.
Kanehiro A, Takahashi K, Soda R, et al. [Effects of a specific thromboxane A2 synthetase inhibitor on lymphocyte and neutrophil functions in adult intractable asthmatics]. Arerugi. 1992;41(5):584-94.
Kanehiro, A., Takahashi, K., Soda, R., Takata, M., Takeda, K., Sugano, H., ... Kimura, I. (1992). [Effects of a specific thromboxane A2 synthetase inhibitor on lymphocyte and neutrophil functions in adult intractable asthmatics]. Arerugi = [Allergy], 41(5), pp. 584-94.
Kanehiro A, et al. [Effects of a Specific Thromboxane A2 Synthetase Inhibitor On Lymphocyte and Neutrophil Functions in Adult Intractable Asthmatics]. Arerugi. 1992;41(5):584-94. PubMed PMID: 1325764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of a specific thromboxane A2 synthetase inhibitor on lymphocyte and neutrophil functions in adult intractable asthmatics]. AU - Kanehiro,A, AU - Takahashi,K, AU - Soda,R, AU - Takata,M, AU - Takeda,K, AU - Sugano,H, AU - Yamagata,K, AU - Katagi,Y, AU - Kimura,I, PY - 1992/5/1/pubmed PY - 1992/5/1/medline PY - 1992/5/1/entrez SP - 584 EP - 94 JF - Arerugi = [Allergy] JO - Arerugi VL - 41 IS - 5 N2 - To clarify whether thromboxane A2 (TXA2) is involved in type III and IV allergy, or so called "cell-mediated allergy", we studied the effect of a specific TXA2 synthetase inhibitor, sodium ozagrel (OKY-046) on peripheral blood mononuclear cells and neutrophils in adult intractable asthmatics. The results revealed, firstly, that lymphocyte blastogenesis and interleukin-2 (IL-2) production from peripheral blood mononuclear cells stimulated by PHA and Candida antigen in intractable asthmatics was significantly suppressed dose-dependently by OKY-046. Secondly, there was a tendency that neutrophil chemotactic factor (NCF) and eosinophil chemotactic factor (ECF) from peripheral blood mononuclear cells stimulated by Candida antigen in intractable asthmatics were suppressed by OKY-046. Thirdly, leukotriene (LTC4) and superoxide (O2-) production from peripheral blood neutrophils in intractable asthmatics was significantly suppressed dose-dependently by OKY-046. That is, OKY-046 has a suppressive effect on type IV allergy caused by lymphocyte activation and on mediator release from neutrophils. These results suggest that TXA2 plays an important role in the development of bronchial asthma and OKY-046 might be a useful drug in the treatment of intractable asthmatics. SN - 0021-4884 UR - https://www.unboundmedicine.com/medline/citation/1325764/[Effects_of_a_specific_thromboxane_A2_synthetase_inhibitor_on_lymphocyte_and_neutrophil_functions_in_adult_intractable_asthmatics]_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -