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Angiotensin II receptor antagonist delays renal damage and stroke in salt-loaded Dahl salt-sensitive rats.
J Hypertens. 1992 Sep; 10(9):949-57.JH

Abstract

OBJECTIVE

To study the effects of blockade of the renin-angiotensin system upon the development of hypertension, end-organ damage and mortality in Dahl salt-sensitive (DSS) rats using an angiotensin II receptor antagonist, losartan.

DESIGN AND METHODS

DSS rats (n = 186) were fed 8% NaCl from 6 to 16 weeks of age. One group received losartan whilst the control group was untreated. Changes in blood pressure and plasma renin activity (PRA), as well as renal and cerebrovascular damage and survival were assessed during the study.

RESULTS

Losartan blunted the blood pressure rise only transiently. Salt loading suppressed PRA in both groups until week 4 and thereafter it rose more markedly in the treated group. With no treatment renal lesions were first detected at 2 weeks, and strokes at 6 weeks. However, losartan transiently decreased the incidence and delayed the progression of renal damage and cerebrovascular lesions (strokes) and increased survival. PRA correlated with renal damage and the incidence of strokes in both groups. Blood pressure only partially affected survival, but did not correlate with stroke incidence.

CONCLUSIONS

These results indicate that whereas the rise in blood pressure is dependent upon sodium loading, morbidity and mortality in salt-loaded DSS rats are associated with activation of the renin-angiotensin system and are only partially related to blood pressure.

Authors+Show Affiliations

Department of Medicine, Cornell University Medical College, New York, NY 10021.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1328376

Citation

von Lutterotti, N, et al. "Angiotensin II Receptor Antagonist Delays Renal Damage and Stroke in Salt-loaded Dahl Salt-sensitive Rats." Journal of Hypertension, vol. 10, no. 9, 1992, pp. 949-57.
von Lutterotti N, Camargo MJ, Campbell WG, et al. Angiotensin II receptor antagonist delays renal damage and stroke in salt-loaded Dahl salt-sensitive rats. J Hypertens. 1992;10(9):949-57.
von Lutterotti, N., Camargo, M. J., Campbell, W. G., Mueller, F. B., Timmermans, P. B., Sealey, J. E., & Laragh, J. H. (1992). Angiotensin II receptor antagonist delays renal damage and stroke in salt-loaded Dahl salt-sensitive rats. Journal of Hypertension, 10(9), 949-57.
von Lutterotti N, et al. Angiotensin II Receptor Antagonist Delays Renal Damage and Stroke in Salt-loaded Dahl Salt-sensitive Rats. J Hypertens. 1992;10(9):949-57. PubMed PMID: 1328376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angiotensin II receptor antagonist delays renal damage and stroke in salt-loaded Dahl salt-sensitive rats. AU - von Lutterotti,N, AU - Camargo,M J, AU - Campbell,W G,Jr AU - Mueller,F B, AU - Timmermans,P B, AU - Sealey,J E, AU - Laragh,J H, PY - 1992/9/11/pubmed PY - 2001/3/28/medline PY - 1992/9/11/entrez SP - 949 EP - 57 JF - Journal of hypertension JO - J. Hypertens. VL - 10 IS - 9 N2 - OBJECTIVE: To study the effects of blockade of the renin-angiotensin system upon the development of hypertension, end-organ damage and mortality in Dahl salt-sensitive (DSS) rats using an angiotensin II receptor antagonist, losartan. DESIGN AND METHODS: DSS rats (n = 186) were fed 8% NaCl from 6 to 16 weeks of age. One group received losartan whilst the control group was untreated. Changes in blood pressure and plasma renin activity (PRA), as well as renal and cerebrovascular damage and survival were assessed during the study. RESULTS: Losartan blunted the blood pressure rise only transiently. Salt loading suppressed PRA in both groups until week 4 and thereafter it rose more markedly in the treated group. With no treatment renal lesions were first detected at 2 weeks, and strokes at 6 weeks. However, losartan transiently decreased the incidence and delayed the progression of renal damage and cerebrovascular lesions (strokes) and increased survival. PRA correlated with renal damage and the incidence of strokes in both groups. Blood pressure only partially affected survival, but did not correlate with stroke incidence. CONCLUSIONS: These results indicate that whereas the rise in blood pressure is dependent upon sodium loading, morbidity and mortality in salt-loaded DSS rats are associated with activation of the renin-angiotensin system and are only partially related to blood pressure. SN - 0263-6352 UR - https://www.unboundmedicine.com/medline/citation/1328376/Angiotensin_II_receptor_antagonist_delays_renal_damage_and_stroke_in_salt_loaded_Dahl_salt_sensitive_rats_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=1328376.ui DB - PRIME DP - Unbound Medicine ER -