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Plasma lipid levels and platelet and neutrophil function in patients with vascular disease following fish oil and olive oil supplementation.
Metabolism. 1992 Oct; 41(10):1059-67.M

Abstract

This double-blind study was designed to examine and compare the effects of supplementing the existing diet with fish oil or olive oil on lipids and cell function in patients with peripheral vascular disease. Thirty-two patients with symptomatic and angiographically demonstrated peripheral vascular disease were screened, matched, and randomly allocated to take either 15 g/d fish oil or olive oil for 4 weeks. Fish oil reduced serum triglyceride levels by 26%, but increased total cholesterol levels due to a significant increase in both low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein-2 cholesterol (HDL2-C). There was a nonsignificant decrease in HDL3-C levels. Olive oil reduced total cholesterol levels, accountable to a significantly decrease in LDL-C levels. Serum thromboxane B2 (TXB2) levels remained unchanged following fish oil, but were significantly increased by olive oil. Urinary excretion of TXB2 and 6-keto-PGF1 alpha was unaffected by either oil supplement. Platelet aggregation, which was measured in platelet-rich plasma in response to two doses of collagen or platelet-activating factor (PAF), was significantly reduced after fish oil, but was increased by olive oil. Following fish oil, there was a significant increase in eicosapentaenoic acid (EPA, 20:5) and docosahexaenoic acid (DHA, 22:6) levels and a decrease in arachidonic acid content of platelet phospholipids. The platelet fatty acid composition after olive oil was unchanged. Fish oil decreased neutrophil leukotriene B4 (LTB4) generation following calcium ionophore stimulation by 33%, while leukotriene B5 levels increased significantly. Neutrophil PAF production and plasma lyso-PAF were unaffected by either oil.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

University Department of Medicine, School of Medicine, Royal Perth Hospital, Western Australia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1328817

Citation

Mori, T A., et al. "Plasma Lipid Levels and Platelet and Neutrophil Function in Patients With Vascular Disease Following Fish Oil and Olive Oil Supplementation." Metabolism: Clinical and Experimental, vol. 41, no. 10, 1992, pp. 1059-67.
Mori TA, Vandongen R, Mahanian F, et al. Plasma lipid levels and platelet and neutrophil function in patients with vascular disease following fish oil and olive oil supplementation. Metabolism. 1992;41(10):1059-67.
Mori, T. A., Vandongen, R., Mahanian, F., & Douglas, A. (1992). Plasma lipid levels and platelet and neutrophil function in patients with vascular disease following fish oil and olive oil supplementation. Metabolism: Clinical and Experimental, 41(10), 1059-67.
Mori TA, et al. Plasma Lipid Levels and Platelet and Neutrophil Function in Patients With Vascular Disease Following Fish Oil and Olive Oil Supplementation. Metabolism. 1992;41(10):1059-67. PubMed PMID: 1328817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma lipid levels and platelet and neutrophil function in patients with vascular disease following fish oil and olive oil supplementation. AU - Mori,T A, AU - Vandongen,R, AU - Mahanian,F, AU - Douglas,A, PY - 1992/10/1/pubmed PY - 1992/10/1/medline PY - 1992/10/1/entrez SP - 1059 EP - 67 JF - Metabolism: clinical and experimental JO - Metabolism VL - 41 IS - 10 N2 - This double-blind study was designed to examine and compare the effects of supplementing the existing diet with fish oil or olive oil on lipids and cell function in patients with peripheral vascular disease. Thirty-two patients with symptomatic and angiographically demonstrated peripheral vascular disease were screened, matched, and randomly allocated to take either 15 g/d fish oil or olive oil for 4 weeks. Fish oil reduced serum triglyceride levels by 26%, but increased total cholesterol levels due to a significant increase in both low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein-2 cholesterol (HDL2-C). There was a nonsignificant decrease in HDL3-C levels. Olive oil reduced total cholesterol levels, accountable to a significantly decrease in LDL-C levels. Serum thromboxane B2 (TXB2) levels remained unchanged following fish oil, but were significantly increased by olive oil. Urinary excretion of TXB2 and 6-keto-PGF1 alpha was unaffected by either oil supplement. Platelet aggregation, which was measured in platelet-rich plasma in response to two doses of collagen or platelet-activating factor (PAF), was significantly reduced after fish oil, but was increased by olive oil. Following fish oil, there was a significant increase in eicosapentaenoic acid (EPA, 20:5) and docosahexaenoic acid (DHA, 22:6) levels and a decrease in arachidonic acid content of platelet phospholipids. The platelet fatty acid composition after olive oil was unchanged. Fish oil decreased neutrophil leukotriene B4 (LTB4) generation following calcium ionophore stimulation by 33%, while leukotriene B5 levels increased significantly. Neutrophil PAF production and plasma lyso-PAF were unaffected by either oil.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/1328817/Plasma_lipid_levels_and_platelet_and_neutrophil_function_in_patients_with_vascular_disease_following_fish_oil_and_olive_oil_supplementation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0026-0495(92)90286-J DB - PRIME DP - Unbound Medicine ER -