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Lack of antinociceptive efficacy of intracerebroventricular [D-Ala2,Glu4]deltorphin, but not [D-Pen2,D-Pen5]enkephalin, in the mu-opioid receptor deficient CXBK mouse.
Eur J Pharmacol. 1992 Jun 17; 216(3):453-6.EJ

Abstract

The antinociceptive efficacy of [D-Pen2,D-Pen5]enkephalin (DPDPE) (delta 1 agonist) and [D-Ala2,Glu4]deltorphin (delta 2 agonist) was evaluated following intracerebroventricular (i.c.v.) or intrathecal (i.t.) administration in CD-1 and CXBK strains of mice using the radiant heat tail-flick test. Following i.c.v. administration, [D-Ala2,Glu4]deltorphin was effective in CD-1, but not CXBK, mice; DPDPE was approximately equiactive in both strains. While i.c.v. [D-Ala2,Glu4]deltorphin did not produce antinociception in the CXBK mouse, it effectively antagonized the antinociceptive actions of i.c.v. DPDPE. [D-Ala2,Glu4]deltorphin was effective following i.t. administration in both strains. These data suggest possible differences in the supraspinal populations of opioid delta receptor subtypes in the CXBK strain. On the basis of previously established selectivity of these agonists, the CXBK mouse may have a predominate population of supraspinal opioid delta 1, rather than delta 2, receptors.

Authors+Show Affiliations

R.W. Johnson Pharmaceutical Research Institute, Spring House, PA 19477.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1330585

Citation

Raffa, R B., et al. "Lack of Antinociceptive Efficacy of Intracerebroventricular [D-Ala2,Glu4]deltorphin, but Not [D-Pen2,D-Pen5]enkephalin, in the Mu-opioid Receptor Deficient CXBK Mouse." European Journal of Pharmacology, vol. 216, no. 3, 1992, pp. 453-6.
Raffa RB, Martinez RP, Porreca F. Lack of antinociceptive efficacy of intracerebroventricular [D-Ala2,Glu4]deltorphin, but not [D-Pen2,D-Pen5]enkephalin, in the mu-opioid receptor deficient CXBK mouse. Eur J Pharmacol. 1992;216(3):453-6.
Raffa, R. B., Martinez, R. P., & Porreca, F. (1992). Lack of antinociceptive efficacy of intracerebroventricular [D-Ala2,Glu4]deltorphin, but not [D-Pen2,D-Pen5]enkephalin, in the mu-opioid receptor deficient CXBK mouse. European Journal of Pharmacology, 216(3), 453-6.
Raffa RB, Martinez RP, Porreca F. Lack of Antinociceptive Efficacy of Intracerebroventricular [D-Ala2,Glu4]deltorphin, but Not [D-Pen2,D-Pen5]enkephalin, in the Mu-opioid Receptor Deficient CXBK Mouse. Eur J Pharmacol. 1992 Jun 17;216(3):453-6. PubMed PMID: 1330585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of antinociceptive efficacy of intracerebroventricular [D-Ala2,Glu4]deltorphin, but not [D-Pen2,D-Pen5]enkephalin, in the mu-opioid receptor deficient CXBK mouse. AU - Raffa,R B, AU - Martinez,R P, AU - Porreca,F, PY - 1992/6/17/pubmed PY - 1992/6/17/medline PY - 1992/6/17/entrez SP - 453 EP - 6 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 216 IS - 3 N2 - The antinociceptive efficacy of [D-Pen2,D-Pen5]enkephalin (DPDPE) (delta 1 agonist) and [D-Ala2,Glu4]deltorphin (delta 2 agonist) was evaluated following intracerebroventricular (i.c.v.) or intrathecal (i.t.) administration in CD-1 and CXBK strains of mice using the radiant heat tail-flick test. Following i.c.v. administration, [D-Ala2,Glu4]deltorphin was effective in CD-1, but not CXBK, mice; DPDPE was approximately equiactive in both strains. While i.c.v. [D-Ala2,Glu4]deltorphin did not produce antinociception in the CXBK mouse, it effectively antagonized the antinociceptive actions of i.c.v. DPDPE. [D-Ala2,Glu4]deltorphin was effective following i.t. administration in both strains. These data suggest possible differences in the supraspinal populations of opioid delta receptor subtypes in the CXBK strain. On the basis of previously established selectivity of these agonists, the CXBK mouse may have a predominate population of supraspinal opioid delta 1, rather than delta 2, receptors. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/1330585/Lack_of_antinociceptive_efficacy_of_intracerebroventricular_[D_Ala2Glu4]deltorphin_but_not_[D_Pen2D_Pen5]enkephalin_in_the_mu_opioid_receptor_deficient_CXBK_mouse_ DB - PRIME DP - Unbound Medicine ER -