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Twenty-four hour blood pressure effect of once-daily lisinopril, enalapril, and placebo in patients with mild to moderate hypertension.
J Hum Hypertens. 1992 Aug; 6(4):325-31.JH

Abstract

This multicentre, double-blind, parallel-group, placebo-controlled study compared the antihypertensive effects of equal doses of two long-acting angiotensin converting enzyme (ACE) inhibitors. After a two-week, placebo run-in phase, 110 patients with mild to moderate hypertension were randomised to receive 10 mg lisinopril or enalapril, or placebo for 4 weeks. Office BPs were measured at regular intervals throughout the study. Twenty-four hour ambulatory blood pressure (ABP) was measured at baseline and after the first and final doses of study drug. Serum ACE activity and aldosterone were obtained concomitantly with each ABP monitoring. Office BP differences from placebo reached (P less than 0.05) or approached (P less than 0.10) statistical significance at all observations for the lisinopril group but were not significant for any observation in the enalapril group and approached significance on two occasions. After four weeks of treatment, ABP analysis revealed that the lisinopril and enalapril groups, when compared with placebo, had similar and significant systolic and diastolic AUC reductions (P less than 0.01) from baseline over the 24 h dosing interval. During the second half of the dosing interval, 13-24 h post drug administration, the lisinopril group was significantly different from placebo (systolic BP, P = 0.002; diastolic BP, P = 0.005) while the enalapril group was not. Both drugs were well tolerated. The results indicate that monotherapy with 10 mg of lisinopril is as effective as with 10 mg of enalapril, and that ABP monitoring is useful in more precisely depicting the clinical effect of the known pharmacokinetic properties of these two agents.

Authors+Show Affiliations

Universal Clinical Research Center, Good Samaritan Hospital, Baltimore, MD 21239.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1331444

Citation

Whelton, A, et al. "Twenty-four Hour Blood Pressure Effect of Once-daily Lisinopril, Enalapril, and Placebo in Patients With Mild to Moderate Hypertension." Journal of Human Hypertension, vol. 6, no. 4, 1992, pp. 325-31.
Whelton A, Dunne B, Glazer N, et al. Twenty-four hour blood pressure effect of once-daily lisinopril, enalapril, and placebo in patients with mild to moderate hypertension. J Hum Hypertens. 1992;6(4):325-31.
Whelton, A., Dunne, B., Glazer, N., Kostis, J. B., Miller, W. E., Rector, D. J., & Tresznewsky, O. N. (1992). Twenty-four hour blood pressure effect of once-daily lisinopril, enalapril, and placebo in patients with mild to moderate hypertension. Journal of Human Hypertension, 6(4), 325-31.
Whelton A, et al. Twenty-four Hour Blood Pressure Effect of Once-daily Lisinopril, Enalapril, and Placebo in Patients With Mild to Moderate Hypertension. J Hum Hypertens. 1992;6(4):325-31. PubMed PMID: 1331444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Twenty-four hour blood pressure effect of once-daily lisinopril, enalapril, and placebo in patients with mild to moderate hypertension. AU - Whelton,A, AU - Dunne,B,Jr AU - Glazer,N, AU - Kostis,J B, AU - Miller,W E, AU - Rector,D J, AU - Tresznewsky,O N, PY - 1992/8/11/pubmed PY - 2001/3/28/medline PY - 1992/8/11/entrez SP - 325 EP - 31 JF - Journal of human hypertension JO - J Hum Hypertens VL - 6 IS - 4 N2 - This multicentre, double-blind, parallel-group, placebo-controlled study compared the antihypertensive effects of equal doses of two long-acting angiotensin converting enzyme (ACE) inhibitors. After a two-week, placebo run-in phase, 110 patients with mild to moderate hypertension were randomised to receive 10 mg lisinopril or enalapril, or placebo for 4 weeks. Office BPs were measured at regular intervals throughout the study. Twenty-four hour ambulatory blood pressure (ABP) was measured at baseline and after the first and final doses of study drug. Serum ACE activity and aldosterone were obtained concomitantly with each ABP monitoring. Office BP differences from placebo reached (P less than 0.05) or approached (P less than 0.10) statistical significance at all observations for the lisinopril group but were not significant for any observation in the enalapril group and approached significance on two occasions. After four weeks of treatment, ABP analysis revealed that the lisinopril and enalapril groups, when compared with placebo, had similar and significant systolic and diastolic AUC reductions (P less than 0.01) from baseline over the 24 h dosing interval. During the second half of the dosing interval, 13-24 h post drug administration, the lisinopril group was significantly different from placebo (systolic BP, P = 0.002; diastolic BP, P = 0.005) while the enalapril group was not. Both drugs were well tolerated. The results indicate that monotherapy with 10 mg of lisinopril is as effective as with 10 mg of enalapril, and that ABP monitoring is useful in more precisely depicting the clinical effect of the known pharmacokinetic properties of these two agents. SN - 0950-9240 UR - https://www.unboundmedicine.com/medline/citation/1331444/Twenty_four_hour_blood_pressure_effect_of_once_daily_lisinopril_enalapril_and_placebo_in_patients_with_mild_to_moderate_hypertension_ L2 - https://medlineplus.gov/highbloodpressure.html DB - PRIME DP - Unbound Medicine ER -