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Selective forebrain fiber tract lesions implicate ventral hippocampal structures in tonic regulation of paraventricular nucleus corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA expression.
Brain Res 1992; 592(1-2):228-38BR

Abstract

The hippocampus appears to be involved in tonic regulation of the hypothalamo-pituitary-adrenocortical axis via interactions with corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP)-containing neurons of the hypothalamic paraventricular nucleus (PVN). To further investigate the anatomical basis of such interactions, lesions were made to forebrain fiber tracts in position to communicate inhibitory information from the hippocampus to the PVN. Total fimbria-fornix transections (TFF) and lateral fimbria-fornix lesions (LFF) both significantly increased CRH mRNA levels in the medial parvocellular PVN, as assayed by semi-quantitative in situ hybridization histochemistry. Medial fimbria-fornix lesions or section of the medial corticohypothalamic tracts (MCHT) did not influence CRH mRNA levels. The LFF group showed increases in both AVP mRNA and ACTH secretion, whereas no other lesion was effective in this regard. The results suggest: (1) hippocampal efferents conferring tonic inhibition of the HPA axis probably originate in regions contributing to the lateral extent of the fornix, representing structures in the ventral subiculum and ventral extent of CA1; (2) projections from the hippocampus to the medial basal hypothalamus (travelling in the MCHT) are unlikely to affect HPA function; (3) hippocampus may influence the PVN CRH/AVP neuron at multiple levels, in that LFF and TFF lesions have differential effects on PVN AVP mRNA levels and ACTH secretion.

Authors+Show Affiliations

Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington 40536-0084.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1333341

Citation

Herman, J P., et al. "Selective Forebrain Fiber Tract Lesions Implicate Ventral Hippocampal Structures in Tonic Regulation of Paraventricular Nucleus Corticotropin-releasing Hormone (CRH) and Arginine Vasopressin (AVP) mRNA Expression." Brain Research, vol. 592, no. 1-2, 1992, pp. 228-38.
Herman JP, Cullinan WE, Young EA, et al. Selective forebrain fiber tract lesions implicate ventral hippocampal structures in tonic regulation of paraventricular nucleus corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA expression. Brain Res. 1992;592(1-2):228-38.
Herman, J. P., Cullinan, W. E., Young, E. A., Akil, H., & Watson, S. J. (1992). Selective forebrain fiber tract lesions implicate ventral hippocampal structures in tonic regulation of paraventricular nucleus corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA expression. Brain Research, 592(1-2), pp. 228-38.
Herman JP, et al. Selective Forebrain Fiber Tract Lesions Implicate Ventral Hippocampal Structures in Tonic Regulation of Paraventricular Nucleus Corticotropin-releasing Hormone (CRH) and Arginine Vasopressin (AVP) mRNA Expression. Brain Res. 1992 Oct 2;592(1-2):228-38. PubMed PMID: 1333341.
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TY - JOUR T1 - Selective forebrain fiber tract lesions implicate ventral hippocampal structures in tonic regulation of paraventricular nucleus corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA expression. AU - Herman,J P, AU - Cullinan,W E, AU - Young,E A, AU - Akil,H, AU - Watson,S J, PY - 1992/10/2/pubmed PY - 1992/10/2/medline PY - 1992/10/2/entrez SP - 228 EP - 38 JF - Brain research JO - Brain Res. VL - 592 IS - 1-2 N2 - The hippocampus appears to be involved in tonic regulation of the hypothalamo-pituitary-adrenocortical axis via interactions with corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP)-containing neurons of the hypothalamic paraventricular nucleus (PVN). To further investigate the anatomical basis of such interactions, lesions were made to forebrain fiber tracts in position to communicate inhibitory information from the hippocampus to the PVN. Total fimbria-fornix transections (TFF) and lateral fimbria-fornix lesions (LFF) both significantly increased CRH mRNA levels in the medial parvocellular PVN, as assayed by semi-quantitative in situ hybridization histochemistry. Medial fimbria-fornix lesions or section of the medial corticohypothalamic tracts (MCHT) did not influence CRH mRNA levels. The LFF group showed increases in both AVP mRNA and ACTH secretion, whereas no other lesion was effective in this regard. The results suggest: (1) hippocampal efferents conferring tonic inhibition of the HPA axis probably originate in regions contributing to the lateral extent of the fornix, representing structures in the ventral subiculum and ventral extent of CA1; (2) projections from the hippocampus to the medial basal hypothalamus (travelling in the MCHT) are unlikely to affect HPA function; (3) hippocampus may influence the PVN CRH/AVP neuron at multiple levels, in that LFF and TFF lesions have differential effects on PVN AVP mRNA levels and ACTH secretion. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/1333341/Selective_forebrain_fiber_tract_lesions_implicate_ventral_hippocampal_structures_in_tonic_regulation_of_paraventricular_nucleus_corticotropin_releasing_hormone__CRH__and_arginine_vasopressin__AVP__mRNA_expression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-8993(92)91680-D DB - PRIME DP - Unbound Medicine ER -